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Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). Additionally we are shipping Pleckstrin Homology Domain Containing, Family O Member 1 Antibodies (56) and Pleckstrin Homology Domain Containing, Family O Member 1 Proteins (7) and many more products for this protein.
Showing 5 out of 11 products:
we firstly revealed the association of CKIP-1 rs2306235 polymorphism with an increased risk of CHF in Chinese Han populations.
we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation.
these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.
the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.
High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.
New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL) and targeting CKIP-1 may be a novel therapeutic target for NHL.
There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 (show PAK1 ELISA Kits) for neoplastic prostate cells transformation.
CKIP-1 interacts with CARMA1 and has an inhibitory effect on PKCtheta (show PRKCQ ELISA Kits);-CBM-NF-kappaB (show NFKB1 ELISA Kits) signaling.
CKIP-1 controlled Smurf1 (show SMURF1 ELISA Kits) expression in colon cancer
overexpression triggers classical monocyte activation and transactivation of the TNF (show TNF ELISA Kits) promoter
PD increased CKIP-1 and Nrf2 (show NFE2L2 ELISA Kits) levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 (show ICAM1 ELISA Kits)
The results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 (show MAPK8 ELISA Kits) phosphorylation and further upregulating IRS-1 (show IRS1 ELISA Kits) phosphorylation and RI.
Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1 (show ICAM1 ELISA Kits)) and fibronectin (show FN1 ELISA Kits) plus activation of Nrf2 (show NFE2L2 ELISA Kits)/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway.
the effect of CKIP-1 on the regulation of bone metabolism and osteogenesis
CKIP-1 is a novel inhibitor of MSC (show MSC ELISA Kits)-originated adipogenesis by enhancing HDAC1 (show HDAC1 ELISA Kits)-associated repression of C/EBPalpha (show CEBPA ELISA Kits).
CKIP-1 interacts with TRAF6 (show TRAF6 ELISA Kits), a ubiquitin ligase required for K63-linked ubiquitination and plasma membrane recruitment of Akt (show AKT1 ELISA Kits), and terminates TRAF6 (show TRAF6 ELISA Kits)-mediated Akt (show AKT1 ELISA Kits) activation.
Knockdown of CKIP-1 in RAW264.7 macrophage cells resulted in impaired cell migration.
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).
pleckstrin homology domain containing, family O member 1
, C-Jun-binding protein
, CK2 interacting protein 1; HQ0024c protein
, CK2-interacting protein 1
, PH domain-containing family O member 1
, casein kinase 2-interacting protein 1
, osteoclast maturation-associated gene 120 protein
, pleckstrin homology domain-containing family O member 1
, CK2 interacting protein 1
, Jun zipper-associated 2
, TNF intracellular domain-interacting protein