Pleiomorphic Adenoma Gene 1 Proteins (PLAG1)

Human Pleiomorphic Adenoma Gene 1 (PLAG1) interaction partners

1. HRAS (show HRAS Proteins) mutations were more common in epithelial-myoepithelial carcinomas (EMCAs) with intact PLAG1 and HMGA2. Most EMCAs arose ex pleomorphic adenoma (PA)and the genetic profile of EMCA varies with the absence or presence of preexisting PA and its cytogenetic signature. Progression to higher grade EMCA with intact PLAG1 and HMGA2 correlates with the presence of TP53 (show TP53 Proteins), FBXW7 (show FBXW7 Proteins) mutations, or SMARCB1 (show SMARCB1 Proteins) deletion.

2. Plag1 expression is lost in malignant transformation from pleomorphic adenoma to carcinoma ex pleomorphic adenoma.

3. MiR (show MLXIP Proteins)-26a can facilitate occurrence of pituitary tumor and invasiveness, probably via inhibiting PLAG1 expression.

4. expression of PLAG1 can be considered a valuable diagnostic marker for recurrent pleomorphic adenoma

5. High PLAG1 expression is associated with pleomorphic adenoma.

6. The sensitivity (55%) and specificity (75%) of PLAG1 in diagnosing PA in FNAs is relatively modest thus limiting its diagnostic utility.

7. The Thr34 of PLAG1 is critical for LpMab-10 recognition.

8. Data indicate that SLIT2 (show SLIT3 Proteins), miR (show MLXIP Proteins)-218-1, RET (show RET Proteins)/PLAG1 and SLIT2 (show SLIT3 Proteins)/ROBO1 (show ROBO1 Proteins) pathway involved in Hirschsprung's disease.

9. Altogether, these data suggest that HMGA2 is an upstream activator of PLAG1.

10. Report illustrates two different tumorigenic pathways implicating PLAG1 in lipoblastoma: amplification through multiple copies of a small marker chromosome derived from chromosome 8, and a paracentric inversion of the long arm of chromosome 8. Review.

Cow (Bovine) Pleiomorphic Adenoma Gene 1 (PLAG1) interaction partners

1. Genome-Wide Association Study Reveals the PLAG1 Gene for Knuckle, Biceps and Shank (show SHANK2 Proteins) Weight in Simmental Beef Cattle.

2. This study demonstrates a strong association of early life body weight with pleiomorphic adenoma gene 1 (PLAG1) genotype in Holstein-Friesian dairy calves. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype.

Mouse (Murine) Pleiomorphic Adenoma Gene 1 (PLAG1) interaction partners

1. Forced expression of PLAG1 under the control of the Pdx1 (show PDX1 Proteins) or Ngn3 (show NEUROG3 Proteins) promoter in murine pancreas induces different degrees of endocrine hormone imbalances.

2. Data indicate a plausible Plag1-Egr1 (show EGR1 Proteins)-CD44 (show CD44 Proteins) regulatory pathway in the T-ICs (show DNAI1 Proteins) of pleomorphic adenomas.

3. Plag1 disruption in mouse differentially affects pre- and postnatal growth and development of organs, with reproductive repercussions

4. aP2 (show TFAP2A Proteins)-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice.

5. Demonstrate upregulation of several genes associated with Igf and Wnt signalling in PLAG1-induced pleomorphic adenomas. Inactivation of Igf2 delays tumour development.

6. Suggest an important role for furin (show FURIN Proteins) in PLAG1-induced salivary gland tumorigenesis in mice.

7. results establish the oncogenic potential of PLAG1 in mammary glands of mice and point towards contributing roles of Igf and Wnt (show WNT2 Proteins) signaling

Pig (Porcine) Pleiomorphic Adenoma Gene 1 (PLAG1) interaction partners

1. distinct loci exist for growth and fatness in the two populations and identified HMGA1 (show HMGA1 Proteins) and PLAG1 as strong candidate genes on SSC7 and SSC4, respectively.