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The protein encoded by PARN is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. Additionally we are shipping PARN Antibodies (66) and PARN Kits (13) and many more products for this protein.
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Pulmonary fibrosis patients with mutations in telomerase reverse transcriptase (show TERT Proteins), telomerase RNA component, regulator of telomere elongation helicase 1 and poly(A)-specific ribonuclease were identified and clinical data were analysed. Genetic mutations in telomere related genes lead to a variety of interstitial lung disease diagnoses that are universally progressive.
PARN polyadenylates the 3' end of telomerase RNA component (known as TERC or hTR (show F2R Proteins)), which serves as the template for telomerase reverse transcriptase (show TERT Proteins)-mediated telomere replication.
PARN is a new component of the ribosome biogenesis machinery in human cells.
provide evidence that PARN can also deadenylate the U6 and RMRP (show NME1 Proteins) RNAs without affecting their levels
poly(A)-specific ribonuclease (PARN) participates in steps leading to 18S pre-rRNA maturation in human cells
we found a polyadenylation-dependent 3' end maturation pathway for the human telomerase RNA that relies on the nuclear poly(A)-binding protein PABPN1 (show PABPN1 Proteins) and the poly(A)-specific RNase PARN.
PARN increased telomerase RNA component levels by deadenylating telomerase RNA component, thereby limiting its degradation by EXOSC10 (show EXOSC10 Proteins).
Large monoallelic mutations of PARN can cause developmental/mental illness. Biallelic PARN mutations cause severe bone marrow failure and central hypomyelination.
results highlight the clinical significance of PARN and NOC on the survival in SCC (show CYP11A1 Proteins) diagnosed patients.
Mutations in the PARN gene cause dyskeratosis congenital.
these data indicate that PARN modulates decay of a defined set of mRNAs in mammalian cells and implicate this deadenylase in coordinating control of genes required for cell movement.
poly(A) polymerase (show PAPOLA Proteins) Gld2 (show PAPD4 Proteins), deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd (show NGDN Proteins)) are components of a dendritic CPEB (show CPEB1 Proteins)-associated polyadenylation apparatus
Solution structures of the cap-binding domain of mouse PARN with and without the m(7)GpppG cap analog reveal a novel cap-binding mode.
A modeled PARN, which shows that the RRM domain from one subunit and the R3H domain from the other subunit enclose the active site.
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, deadenylation nuclease
, poly(A)-specific ribonuclease (deadenylation nuclease)
, poly(A)-specific ribonuclease PARN
, polyadenylate-specific ribonuclease