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The protein encoded by PCGF6 contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. Additionally we are shipping PCGF6 Kits (9) and PCGF6 Proteins (5) and many more products for this protein.
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Pcgf6 acts as a master regulator to maintain embryonic stem cell identity.
regulation by cell cycle-dependent phosphorylation
Thus, we did not find evidence for uniquely interacting partner proteins using this approach, but did identify four new lamin A/C interactive partners
Study shows that JARID1d and MBLR occupy human Engrailed 2 gene and regulate its expression and histone H3 lysine 4 methylation levels.
MEL-18 bound to HSF2 inhibits its sumoylation by binding to and inhibiting the activity of UBC9 enzymes in the vicinity of HSF2.
Mel-18 overexpression showed reduced glycogen synthase kinase-3beta phosphorylation, beta-catenin nuclear localization, T-cell factor/lymphoid enhancer factor promoter activity, and cyclin D1 mRNA level
Conditional ablation of Pcgf6 in embryonic stem cells leads to robust de-repression of germ cell-related genes, in turn affecting cell growth and viability.
The results identify two key regulators, PCGF6 and JARID1c that temper dendritic cells (DC) activation and implicate active transcriptional silencing via histone demethylation as a previously unappreciated mechanism for regulating DC activation and quiescence.
Pcgf6 is essential for recruitment of PRC1.6 to chromatin. Our results reveal a previously uncharacterized, H2AK119ub1-independent chromatin assembly associated with PRC1.6 complex
that Pcgf6 is nonredundantly involved in maintaining the pluripotent nature of embryonic stem cells and it functions in induced pluripotent stem reprogramming
The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.
polycomb group ring finger 6
, polycomb group RING finger protein 6
, polycomb group RING finger protein 6-like
, Mel18 and Bmi1-like RING finger protein
, ring finger protein 134
, Mel18- and Bmi1-like RING finger protein