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Polymerase (DNA Directed), gamma 2, Accessory Subunit Proteins (POLG2)

POLG2 encodes the processivity subunit of the mitochondrial DNA polymerase gamma. Additionally we are shipping Polymerase (DNA Directed), gamma 2, Accessory Subunit Antibodies (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat POLG2 POLG2 303612  
POLG2 11232 Q9UHN1
Mouse POLG2 POLG2 50776 Q9QZM2
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Top Polymerase (DNA Directed), gamma 2, Accessory Subunit Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$860.20
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$3,166.17
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POLG2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Polymerase (DNA Directed), gamma 2, Accessory Subunit (POLG2) Interaction Partners

Human Polymerase (DNA Directed), gamma 2, Accessory Subunit (POLG2) interaction partners

  1. This is the first report of a patient with a homozygous mutation in POLG2 and with a clinical presentation of severe hepatic failure and mitochondrial depletion.

  2. Results show that polymorphisms at POLG2 and POLRMT (show POLRMT Proteins) increased risk of oral cancer and leukoplakia, respectively, probably modulating synthesis and activity of the enzymes.

  3. The authors describe the molecular characterization of a potential dominant POLG2 mutation (p.R369G) in a patient with autosomal dominant progressive external ophthalmoplegia and multiple mtDNA deletions.

  4. Data show that rs17650301 in POLG2 is a good candidate marker for UBC (show RPS27A Proteins) invasiveness in Japanese males.

  5. The biochemical analysis helps explain the pathogenesis of POLG2 mutations in mitochondrial disease.

  6. human pol gammaB exhibits a catalytic subunit- and substrate DNA-dependent dimerization.

  7. PolB (show POLB Proteins) gamma can bind double-stranded DNA and may play a role in DNA replication or repair

  8. Study represents the first structure-function analysis of the thumb subdomain in pol gamma (show POLG Proteins) and examines the consequences of mitochondrial disease mutations in this region.

  9. Both increased and decreased expression of POLGbeta altered nucleoid structure and precipitated a marked decrease in 7S DNA molecules, which form short displacement-loops on mitochondrial DNA.

Mouse (Murine) Polymerase (DNA Directed), gamma 2, Accessory Subunit (POLG2) interaction partners

  1. Our data indicate that Polg2 function is critical to mammalian embryogenesis and mtDNA replication, and that a single copy of Polg2 is sufficient to sustain life.

Polymerase (DNA Directed), gamma 2, Accessory Subunit (POLG2) Protein Profile

Protein Summary

This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.

Gene names and symbols associated with POLG2

  • DNA polymerase gamma 2, accessory subunit (Polg2)
  • DNA polymerase gamma 2, accessory subunit (POLG2)
  • polymerase (DNA directed), gamma 2, accessory subunit (polg2)
  • polymerase (DNA directed), gamma 2, accessory subunit (Polg2)
  • polymerase (DNA directed), gamma 2, accessory subunit L homeolog (polg2.L)
  • HP55 protein
  • im:7158733 protein
  • mtpolb protein
  • PEOA4 protein
  • POLB protein
  • POLG-BETA protein
  • POLG2 protein
  • POLGB protein
  • si:ch211-157f15.3 protein

Protein level used designations for POLG2

DNA polymerase subunit gamma-2, mitochondrial , polymerase (DNA directed), gamma 2, accessory subunit , DNA polymerase subunit gamma-2, mitochondrial-like , DNA polymerase gamma accessory 55 kDa subunit , mitochondrial DNA polymerase accessory subunit , mitochondrial DNA polymerase subunit gamma-2 , mitochondrial DNA polymerase, accessory subunit , p55 , mitochondrial polymerase gamma 2 , mtPolB , polG-beta , polymerase, gamma 2

GENE ID SPECIES
303612 Rattus norvegicus
417418 Gallus gallus
455266 Pan troglodytes
490910 Canis lupus familiaris
717856 Macaca mulatta
100029647 Monodelphis domestica
100064219 Equus caballus
100397872 Callithrix jacchus
100458861 Pongo abelii
100150674 Danio rerio
11232 Homo sapiens
50776 Mus musculus
505152 Bos taurus
398112 Xenopus laevis
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