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Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron.
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Study establishes the distribution profile of SK2 channel protein in human brain.The expression of SK2 human isoform b in brain could explain the variability of electrophysiological findings observed with SK2 channels.
These results provide new insights into the regulation of SK2 channel trafficking by the cytoskeletal proteins FLNA (show FLNA ELISA Kits) and alpha-actinin2, involving distinct recycling pathways
There was a significant association between the KCNN2 variants and clinically significant VTa. These findings suggest an association between KCNN2 and VTa; it also appears that KCNN2 variants may be adjunctive markers for risk stratification in patients susceptible to SCD (show SCD ELISA Kits).
The ER SK2 channel activation preserves ER Ca(2 (show CA2 ELISA Kits)+) uptake and retention which determines cell survival in conditions where sustained ER stress contributes to progressive neuronal death.
Differentiated dopaminergic neurons expressed low levels of SK2 channels and high levels of SK1 and SK3 channels.
KCNN2 gene can have an important role in the development of coronary artery aneurysms in Kawasaki disease.
Increase in both Ca(2 (show CA2 ELISA Kits)+) sensitivity and SK2 protein expression contributes to the IKAS upregulation in failing human ventricles.
Decreased expression of small-conductance Ca2 (show CA2 ELISA Kits)+-activated K+ channels SK1 and SK2 in human chronic atrial fibrillation
RT-PCR analysis showed strong expression of SK2 mRNA in the normal human colon.
Because of the marked differential expression of SK2 channels in the heart, specific ligands for Ca2 (show CA2 ELISA Kits)+-activated K+ currents may offer a unique therapeutic opportunity to modify atrial cells without interfering with ventricular myocytes
SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2 (show CA2 ELISA Kits)+) uptake.
Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2 (show CA2 ELISA Kits)+)-activated K(+) (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of serotinin (5-HT (show DDC ELISA Kits)) neuronal excitability.
SK2 is nuclear in primary neurons and, unexpectedly, overexpressed SK2 is neurotoxic in a dose-dependent manner.. We also found that SK2 is hyperphosphorylated in the brain samples from a model of HD, the BACHD mice.Our results identify a novel regulator of mutant huntingtin (show HTT ELISA Kits)-mediated neurotoxicity and provide a new target for developing developing therapies for Huntington disease (show HTT ELISA Kits)
Thus, MPP2 (show MPP2 ELISA Kits) is a novel synaptic scaffold that is required for proper synaptic localization and function of SK2-containing channels.
Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias.
enhanced SK2 channel control over NMDAR contributes to LTP impairment via increased PP2A activity following context dependent sensitization to morphine.
This study reveleated that outer hair cells of SK2 knockout mice had few small efferent terminals. Synaptic cisterns were present, but smaller than those of wild-type littermates.
SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats
Mitochondrial small conductance SK2 channels prevent glutamate (show GRIN1 ELISA Kits)-induced oxytosis and mitochondrial dysfunction.
Virtually all Cav2.1 (show CACNA1A ELISA Kits) clusters are colocalized in Purkinje cells with two types of calcium-activated potassium channels, SK2 and BK.
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
, small conductance calcium-activated potassium channel protein 2
, small-conductance calcium-activated potassium channel
, apamin-sensitive small-conductance Ca2+-activated potassium channel
, small conductance potassium channel type 2
, SKCa 2
, small conductance calcium-activated potassium channel subfamily N member 2
, small conductance calcium-activated channel, subfamily N, member 2