Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2) ELISA Kits

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Additionally we are shipping KCNN2 Antibodies (46) and KCNN2 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
KCNN2 3781 Q9H2S1
Anti-Mouse KCNN2 KCNN2 140492 P58390
Anti-Rat KCNN2 KCNN2 54262 P70604
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Top KCNN2 ELISA Kits at antibodies-online.com

Showing 3 out of 7 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.059 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$810.53
Details
Human < 0.059 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
$867.02
Details
Please inquire
  10 reactions Log in to see 4 to 6 Days
$549.00
Details

More ELISA Kits for KCNN2 Interaction Partners

Human Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2) interaction partners

  1. SK current is increased via the enhanced activation of CaMKII (show CAMK2G ELISA Kits) in patients with atrial fibrillation.

  2. Study establishes the distribution profile of SK2 channel protein in human brain.The expression of SK2 human isoform b in brain could explain the variability of electrophysiological findings observed with SK2 channels.

  3. These results provide new insights into the regulation of SK2 channel trafficking by the cytoskeletal proteins FLNA (show FLNA ELISA Kits) and alpha-actinin2, involving distinct recycling pathways

  4. There was a significant association between the KCNN2 variants and clinically significant VTa. These findings suggest an association between KCNN2 and VTa; it also appears that KCNN2 variants may be adjunctive markers for risk stratification in patients susceptible to SCD (show SCD ELISA Kits).

  5. The ER SK2 channel activation preserves ER Ca(2 (show CA2 ELISA Kits)+) uptake and retention which determines cell survival in conditions where sustained ER stress contributes to progressive neuronal death.

  6. Differentiated dopaminergic neurons expressed low levels of SK2 channels and high levels of SK1 and SK3 channels.

  7. KCNN2 gene can have an important role in the development of coronary artery aneurysms in Kawasaki disease.

  8. Increase in both Ca(2 (show CA2 ELISA Kits)+) sensitivity and SK2 protein expression contributes to the IKAS upregulation in failing human ventricles.

  9. Decreased expression of small-conductance Ca2 (show CA2 ELISA Kits)+-activated K+ channels SK1 and SK2 in human chronic atrial fibrillation

  10. RT-PCR analysis showed strong expression of SK2 mRNA in the normal human colon.

Mouse (Murine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2) interaction partners

  1. SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2 (show CA2 ELISA Kits)+) uptake.

  2. Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2 (show CA2 ELISA Kits)+)-activated K(+) (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of serotinin (5-HT (show DDC ELISA Kits)) neuronal excitability.

  3. SK2 is nuclear in primary neurons and, unexpectedly, overexpressed SK2 is neurotoxic in a dose-dependent manner.. We also found that SK2 is hyperphosphorylated in the brain samples from a model of HD, the BACHD mice.Our results identify a novel regulator of mutant huntingtin (show HTT ELISA Kits)-mediated neurotoxicity and provide a new target for developing developing therapies for Huntington disease (show HTT ELISA Kits)

  4. Thus, MPP2 (show MPP2 ELISA Kits) is a novel synaptic scaffold that is required for proper synaptic localization and function of SK2-containing channels.

  5. Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias.

  6. enhanced SK2 channel control over NMDAR contributes to LTP impairment via increased PP2A activity following context dependent sensitization to morphine.

  7. This study reveleated that outer hair cells of SK2 knockout mice had few small efferent terminals. Synaptic cisterns were present, but smaller than those of wild-type littermates.

  8. SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats

  9. Mitochondrial small conductance SK2 channels prevent glutamate (show GRIN1 ELISA Kits)-induced oxytosis and mitochondrial dysfunction.

  10. Virtually all Cav2.1 (show CACNA1A ELISA Kits) clusters are colocalized in Purkinje cells with two types of calcium-activated potassium channels, SK2 and BK.

KCNN2 Antigen Profile

Antigen Summary

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KCNN2

  • potassium calcium-activated channel subfamily N member 2 (KCNN2) antibody
  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (Kcnn2) antibody
  • potassium calcium-activated channel subfamily N member 2 (Kcnn2) antibody
  • fri antibody
  • hSK2 antibody
  • KCa2.2 antibody
  • KCNN2 antibody
  • SK2 antibody
  • SKCA2 antibody
  • SKCa 2 antibody

Protein level used designations for KCNN2

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 , small conductance calcium-activated potassium channel protein 2 , small-conductance calcium-activated potassium channel , apamin-sensitive small-conductance Ca2+-activated potassium channel , small conductance potassium channel type 2 , SKCa 2 , small conductance calcium-activated potassium channel subfamily N member 2 , SK2 , SKCa2 , small conductance calcium-activated channel, subfamily N, member 2

GENE ID SPECIES
695374 Macaca mulatta
100016183 Monodelphis domestica
100172000 Pongo abelii
100230275 Taeniopygia guttata
100589687 Nomascus leucogenys
395579 Gallus gallus
3781 Homo sapiens
474640 Canis lupus familiaris
404177 Bos taurus
140492 Mus musculus
54262 Rattus norvegicus
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