anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 3 (KCNQ3) Antibodies

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNQ3 3786 O43525
KCNQ3 29682  
KCNQ3 110862 Q8K3F6
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Top anti-KCNQ3 Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Kcnq3 Antibody   Titration: 1.0 ug/ml   Positive Control: Mouse Heart Lanes:   100 ug CHO cell lysate  Primary Antibody Dilution:   1:1000  Secondary Antibody:   Goat anti-rabbit HRP  Secondary Antibody Dilution:   1:25000  Gene Name:   Kcnq3  Submitted by:   Anonymous 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 6 to 7 Days
$291.53
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of KCNQ3 Antibody (C-term) in mouse bladder tissue lysates (35ug/lane). This demonstrates the KCNQ3 antibody detected the KCNQ3 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain, using Kv7.3/KCNQ3 (Phospho-Thr246) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv7.3/KCNQ3 (Ab-246) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$446.88
Details
Mouse Rabbit Un-conjugated WB Western blot analysis in mouse bladder tissue lysates (35ug/lane). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 11 to 14 Days
$507.83
Details
Chinese Hamster Rabbit Un-conjugated WB Western Blot: Kv7.3 Antibody [NBP1-74102] - Lanes: 100 ug CHO cell lysate Primary Antibody Dilution: 1 : 1000 Secondary Antibody: Goat anti-rabbit HRP Secondary Antibody Dilution: 1 : 25000 Gene name: Kcnq3 Submitted by: Anonymous. Western Blot: Kv7.3 Antibody [NBP1-74102] - Kv7.3 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Heart. 100 μL Log in to see 8 to 11 Days
$488.73
Details

Top referenced anti-KCNQ3 Antibodies

  1. Chinese Hamster Polyclonal KCNQ3 Primary Antibody for WB - ABIN4893534 : Ruan, Dietrich, Liu, Zimmer, Li, Singh, Zhang, Yin, Wu, Horvath, Yang: O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat. in Cell 2014 (PubMed)

  2. Human Polyclonal KCNQ3 Primary Antibody for ELISA - ABIN451812 : Ekberg, Schuetz, Boase, Conroy, Manning, Kumar, Poronnik, Adams: Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2. in The Journal of biological chemistry 2007 (PubMed)

More Antibodies against KCNQ3 Interaction Partners

Zebrafish Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 3 (KCNQ3) interaction partners

  1. These results indicate that functional K(v)7 channels are expressed in the larval zebrafish nervous system and could play a direct role in generation of seizure activity.

Human Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 3 (KCNQ3) interaction partners

  1. Phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid, which directly activates KCNQ5 and KCNQ3 via W265.

  2. An optimum cholesterol level in the plasma membrane is required for the proper functioning of Kv7.2/Kv7.3 channels.

  3. In the present work, a pharmacophore-based 3D-QSAR model was generated for a series of N-pyridyl and pyrimidine benzamides possessing KCNQ2/Q3 opening activity. The pharmacophore model generated contains one hydrogen bond donor (D), one hydrophobic (H), and two aromatic rings (R). They are the crucial molecular write-up detailing predicted binding efficacy of high affinity and low affinity ligands for KCNQ2/Q3 opening a

  4. Tannic acid activates Kv7.4 and Kv7.3/7.5 K(+) channels resulting in vasodilation.

  5. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.

  6. Carboxyl terminus helix C-D linker residues play a role in KCNQ3 current amplitudes by controlling the exit of the KCNQ3 channel from the endoplasmic reticulum.

  7. a structural mechanism for the gating of the Kv7.3 PM and for the site of action of RTG as a Kv7.2/Kv7.3 K(+) current activator.

  8. In bipolar disorder patients' prefrontal cortex, Kcnq3 expression was decreased, DNA methylation was decreased, and Kcnq3 mRNA was decreased compared to controls.

  9. the clinical and EEG features of this patient further on expand the phenotypic variability of KCNQ3 gene mutations

  10. Phosphorylation of KCNQ2 and KCNQ3 anchor domains by protein kinase CK2 augments binding to AnkG.

  11. mutations in KCNQ3, similarly to KCNQ2, can be found in patients with more severe phenotypes including intellectual disability

  12. the present results suggest that gain-of-function mutations in Kv7.2/3 currents may cause human epilepsy with a severe clinical course

  13. We described clinical, genetic, and functional data from 17 families with a diagnosis of benign familial neonatal epilepsy caused by KCNQ2 or KCNQ3 mutations and we showed that some mutations lead to a reduction of Q2 channel regulation by syntaxin-1A.

  14. We monitored KCNQ2/3 channel currents and translocation of PHPLCdelta1 domains as real-time indicators of PM PI(4,5)P2, and translocation of PHOSH2x2, and PHOSH1 domains as indicators of plasma membrane and Golgi PI(4)P, respectively.

  15. A medium-throughput assay reliably detects changes in the biophysical properties of three classes of KCNQ2/3 channels and peak current amplitude and therefore may serve as a reliable assay to evaluate KCNQ2/3 openers and blockers.

  16. the single KCNQ channel in Drosophila (dKCNQ) has similar electrophysiological properties to neuronal KCNQ2/3

  17. This study demonistrated that benign neonatal sleep myoclonus can show autosomal dominant inheritance but not allelic to KCNQ3.

  18. KCNQ3 mutations might be involved in families with infantile seizures.

  19. the Kv7.2-Kv7.3 heteromer assembles as a tetramer with a predominantly 2:2 subunit stoichiometry and with a random subunit arrangement.

  20. constitutive tethering of calmodulin is not required for Kv7 channel function

Mouse (Murine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 3 (KCNQ3) interaction partners

  1. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.

  2. KCNQ3 plays an essential role in maintaining the slow afterhyperpolarization under low phosphatidylinositol diphosphate conditions.

  3. Mechanosensitivity of Skin Down-hair mechanoeceptors is increased in Kcnq3-/- and in Kcnq2+/-/Kcnq3-/- Mutant Mice.

  4. Resilience to tinnitus is developed in mice that show a re-emergence of KCNQ2/3 channel activity and a reduction in HCN channel activity.

  5. Data show that a reduction in Kv7.2/3 channel activity is essential for tinnitus induction and for the tinnitus-specific hyperactivity.

  6. Retigabine is more effective on KCNQ3 than KCNQ2, whereas ZnPy is more effective on KCNQ2 with no detectable effect on KCNQ3.

  7. Results show that in the same protein complex in which PKA augments L currents, AKAP79/150 directs calcineurin to activate NFAT and initiate a longer-term feedback loop that upregulates M-channel expression, countering increased neuronal excitability.

  8. This study demonistrated that kcnq3 gene expression in mouse dorsal raphe nucleus

  9. Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 > KCNQ4 > KCNQ5 > KCNQ1 > KCNQ2.

  10. These findings provide novel evidence that KCNQ2/3 channels could be an important regulator in neuronal apoptosis.

  11. A widespread KCNQ3N immunoreactivity predominantly of neuropil but also of somata was detected in different regions of the adult mouse brain, in particular in the hippocampus, cortex, thalamus and cerebellum.

  12. This study evaluated a model of benign familial neonatal convulsions in transgenic mice with a knockin mutation for KCNQ2 and KCNQ3 mutations.

  13. expression of Kcnq2 is in the modiolus and organ of Corti, while Kcnq3 expression was also detected in the cochlear lateral wall and both in spiral ganglion neurons

  14. KCNQ2 and KCNQ3 channels contribute to the apamin-insensitive afterhyperpolarization.

  15. disrupting the Kcnq2/Kcnq3 channel leads to neuronal phenotype

KCNQ3 Antigen Profile

Protein Summary

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found.

Gene names and symbols associated with KCNQ3

  • potassium voltage-gated channel subfamily Q member 3 (KCNQ3) antibody
  • potassium voltage-gated channel, KQT-like subfamily, member 3 (kcnq3) antibody
  • potassium voltage-gated channel subfamily Q member 3 (Kcnq3) antibody
  • potassium voltage-gated channel, subfamily Q, member 3 (Kcnq3) antibody
  • BFNC2 antibody
  • EBN2 antibody
  • KCNQ3 antibody
  • KV7.3 antibody
  • si:ch211-66b9.3 antibody

Protein level used designations for KCNQ3

potassium voltage-gated channel, KQT-like subfamily, member 3 , potassium voltage-gated channel KQT-like protein 3 , potassium voltage-gated channel subfamily KQT member 3 , potassium channel subunit alpha KvLQT3 , potassium channel, voltage-gated, subfamily Q, member 3 , voltage-gated potassium channel subunit Kv7.3 , KQT-like 3 , potassium voltage-gated channel, subfamily Q, member 3

GENE ID SPECIES
464403 Pan troglodytes
799747 Danio rerio
100026683 Monodelphis domestica
3786 Homo sapiens
29682 Rattus norvegicus
281884 Bos taurus
110862 Mus musculus
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