anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Antibodies

KCNH2 encodes a voltage-activated potassium channel belonging to the eag family. Additionally we are shipping Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNH2 3757 Q12809
KCNH2 16511  
KCNH2 117018 O08962
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Top anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Antibodies at antibodies-online.com

Showing 10 out of 92 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KCNH2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  OVCAR-3 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Kcnh2 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6269498 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6269498 at 1/100 staining rat brain tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$450.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Anti-KCNH2 / Kv11.1 antibody  ABIN1048984 IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-KCNH2 / Kv11.1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Cow Rabbit Un-conjugated IHC, IHC (p) Anti-KCNH2 / Kv11.1 antibody  ABIN1048985 IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-KCNH2 / Kv11.1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of KCNH2 Antibody (Center) (ABIN652759) in CEM cell line lysates (35 µg/lane).KCNH2 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts of Mouse brain tissue lysate, using KCNH2antibody. The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of KCNH2 Antibody (Center) in CEM cell line lysates (35ug/lane).KCNH2 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using KCNH2 antibody. 100 μL Log in to see 16 Days
$334.77
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB 50 μg Log in to see 7 to 9 Days
$551.83
Details

Top referenced anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Antibodies

  1. Dog (Canine) Polyclonal KCNH2 Primary Antibody for IF (p), IHC (p) - ABIN734843 : Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014 (PubMed)

More Antibodies against Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Interaction Partners

Human Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. novel variants in SCN5A (show SCN5A Antibodies), KCNH2 and KCNQ1 (show KCNQ1 Antibodies) are associated with congenital long QT syndrome in a Polish population

  2. Data have defined the requirements for the susceptibility of LQT2 mutations to nonsense-mediated mRNA decay (NMD), and suggested that the majority of LQT2 nonsense and frameshift mutations are potential targets of NMD. Given that these specific mutations account for more than 30% of reported LQT2 mutations, the degradation of mutant mRNA by NMD is an important disease causing mechanism in the pathogenesis of LQT2.

  3. Applying the computational approaches in this study, have helped to elucidate the possible binding patterns and time evaluation dynamics of this drug at hERG1 channel models (both in its open and open-inactivated states) together with the crucial amino acid residues that mostly contribute in binding processes via interaction binding energy decomposition analysis.

  4. In a family afflicted by recurrent SIDS (show IDS Antibodies), post-mortem directed genetic testing was conducted. We demonstrate that despite the variant being present in both SIDS (show IDS Antibodies) cases, KCNH2-p.Pro963Thr did not appreciably alter membrane surface expression of the hERG channel, or the biophysical properties, including deactivation gating. These findings suggest that KCNH2-p.Pro963Thr is not a monogenic disease-causing LQTS mutation

  5. It was also found that drug ionization may play a crucial role in preferential targeting to the open-inactivated state of the pore domain. pH-dependent hERG blockade by dofetilie was studied with patch-clamp recordings. The results show that low pH increases the extent and speed of drug-induced block.

  6. Our results underscore the importance of careful characterization of the impact of epitope fusion tags and of confirming complete sequence accuracy prior to genotype-phenotype studies for ion channel proteins such as hERG.

  7. Data show that ether-a-go-go-related 1 (hERG1) ion channel expression knockdown elicited a reversion of the epithelial to the mesenchymal state (EMT (show ITK Antibodies)) profile in colorectal cancer HCT116 cells with a reacquisition of the epithelial-like profile.

  8. TBX20 (show TBX20 Antibodies) can be considered a KCNH2-modifying gene.

  9. The KCNH2 intron 9 branch point is linked to the regulation of KCNH2 isoform expression in cardiomyocytes.

  10. Our findings suggest that the K897T polymorphism of KCNH2 may contribute to the occurrence of syncope in Andersen-Tawil syndrome.

Guinea Pig Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. data suggest that CO induces arrhythmias in guinea pig cardiac myocytes via the ONOO(-)-mediated inhibition of Kv11.1 (show KCNV2 Antibodies) K(+) channels

Mouse (Murine) Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. PKD1 (show PKD1 Antibodies) mediates the PKC effects on KV11.1 (show KCNV2 Antibodies) and we found that PKD (show PRKD1 Antibodies) targets S284 in the N-terminus of the channel.

  2. histone H4 (show HIST1H4H Antibodies) hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (Kcnj2 (show KCNJ2 Antibodies), Kcnj3 (show KCNJ3 Antibodies), Kcnj5 (show KCNJ5 Antibodies), Kcnj11 (show KCNJ11 Antibodies), and Kcnh2)

  3. Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 (show NKX2-5 Antibodies) regulates the gene encoding Kcnh2 channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 (show NKX2-5 Antibodies) dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies

  4. Report altered protein trafficking/function of mouse ERG K(+) channel clones.

  5. Enhancement of HERG protein expression through Hsp90 (show HSP90 Antibodies) inhibition of CHIP binding might be a novel therapeutic strategy for long QT syndrome 2 caused by trafficking abnormalities of HERG proteins.

  6. The findings of this study suggested that MERG1a may not modulate Murf1 (show TRIM63 Antibodies) expression through the AKT (show AKT1 Antibodies)/FOXO (show FOXO3 Antibodies) pathway.

  7. Data indicate presence of KCNH2 in left/right atria & indicate functional interaction between KCNH2 & KCNA5 (show KCNA5 Antibodies). Kinetic analyses confirm KCNH2 as "rapid" and KCNA5 (show KCNA5 Antibodies) as "ultra rapid" potassium channels.

  8. Knockdown of mERG1 transcripts with small interfering RNA (siRNA) dramatically reduced I (Kr) amplitude, confirming the molecular link of mERG1 and I (Kr) in HL-1 (show ASGR1 Antibodies) cells.

  9. The LQT2 missense mutations G601S and N470D hERG exhibited altered protein trafficking in mouse cardiomyocytes.

  10. ERG1 B is necessary for I(Kr) expression in the surface membrane of adult myocytes. Knockout of ERG1 B predisposes mice to episodic sinus bradycardia.

Rabbit Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. In transgenic long QT syndrome rabbits, Kv11.1 channel activation shortens the cardiac activation potential duration.

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Antigen Profile

Protein Summary

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.

Gene names and symbols associated with KCNH2

  • potassium voltage-gated channel subfamily H member 2 (KCNH2) antibody
  • potassium voltage-gated channel subfamily H member 2 (Kcnh2) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (Kcnh2) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2) antibody
  • AI326795 antibody
  • cerg antibody
  • derg antibody
  • erg antibody
  • erg1 antibody
  • gp-erg antibody
  • HERG antibody
  • HERG1 antibody
  • KCNH2 antibody
  • Kv11.1 antibody
  • LQT antibody
  • Lqt2 antibody
  • M-erg antibody
  • Merg1 antibody
  • merg1a antibody
  • merg1b antibody
  • SQT1 antibody

Protein level used designations for KCNH2

ERG-1 , H-ERG , eag homolog , eag-related protein 1 , ether-a-go-go-related gene potassium channel 1 , ether-a-go-go-related potassium channel protein , ether-a-go-go-related protein 1 , hERG-1 , potassium voltage-gated channel subfamily H member 2 , voltage-gated potassium channel subunit Kv11.1 , potassium voltage-gated channel, subfamily H (eag-related), member 2 , potassium channel protein ERG , potassium voltage-gated channel subfamily H member 2-like , c-ERG , eag related protein 1 , ether-a-go-go related gene potassium channel 1 , MERG , ether a go-go related , RERG , r-ERG , ERG1 , ra-erg , ventricular ERG K+ channel subunit , voltage-gated potassium channel 11.1 , voltage-gated potassium channel, subfamily H, member 2

GENE ID SPECIES
3757 Homo sapiens
463894 Pan troglodytes
100064000 Equus caballus
100135563 Cavia porcellus
100413935 Callithrix jacchus
100447585 Pongo abelii
403761 Canis lupus familiaris
16511 Mus musculus
117018 Rattus norvegicus
100009242 Oryctolagus cuniculus
100858122 Gallus gallus
100523293 Sus scrofa
539971 Bos taurus
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