Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteins (KCNH2)

KCNH2 encodes a voltage-activated potassium channel belonging to the eag family. Additionally we are shipping Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Antibodies (93) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNH2 3757 Q12809
KCNH2 16511  
Rat KCNH2 KCNH2 117018 O08962
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteins at antibodies-online.com

Showing 4 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Wheat germ Human Un-conjugated   2 μg Log in to see 11 to 12 Days
$491.43
Details

KCNH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)
,

More Proteins for Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaction Partners

Human Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. QTi derived from Holter recordings predicts the mutation carrier state in families with Long QT syndromes. Increased 24-hour QT-RR slope is a diagnostic hint pointing in the direction of LQT2.

  2. The notorious ligand promiscuity of this channel earmarked hERG as one of the most important antitargets to be considered in early stages of drug development process. Herein we report on the development of an innovative and freely accessible web server for early identification of putative hERG blockers and non-blockers in chemical libraries.

  3. In HEK293 cells, CO inhibited wild-type, but not C723S mutant, Kv11.1 K(+) currents. Inhibition was prevented by an antioxidant, mitochondrial inhibitors, or inhibition of NO formation.

  4. data provide novel information about hypoxia-mediated hERG dysfunction and may have biological and clinical implications in hypoxia-associated diseases.

  5. Relative expression of Kv11.1 C-terminal isoforms can be regulated by modified U1 snRNA.

  6. Expression and functions of hERG are regulated by specific miRNAs.

  7. The present study shows clinical and genetic aspects of p.His492Tyr carriers and demonstrated two major findings; (1) KCNH2 p.His492Tyr variant presented symptomatic Romano-Ward syndrome in the presence of another LQTS-related gene mutation, in contrast, (2) heterozygous carriers had mild QT prolongation while additional triggers can be "latent" form of p.His492Tyr

  8. Homozygous carriers of CYP2B6 (show CYP2B6 Proteins)*6 allele may be at increased risk for EFV-induced QT interval prolongation via inhibition of hERG.

  9. ER-located J-protein chaperones were identified as key regulators for the iogenesis and physiological function of ERG (show ERG Proteins) K+ channels. They regulate two distinct aspects of K+ channel (show KCNC4 Proteins) biogenesis, the stabilization and assembly of channel subunits.

  10. atypical sequence of the pore helix of hERG may play a key role in determining how anionic lipids influence its gating

Zebrafish Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. The data support the conclusion that zerg-2 and zerg-3 are apparent orthologues of different human genes encoding potassium ion channels, but that their functions have switched compared to the respective human proteins.

  3. role for ERG in leukocytes, where inhibition or translational knockdown of ERG resulted in significant attenuation of the inflammatory response to an infectious stimulus

  4. Mutations in kcnh2 recapitulate the human long QT syndrome (LQTS) phenotype as manifested by prolongation of action potentials and prolonged QT interval in the first animal genetic model of human LQTS type 2.

  5. The reg mutation in the voltage sensor of the ether-a-go-go-related gene gene K+ channel (show KCNC4 Proteins) causes premature zERG channel activation & defective inactivation, resulting in shortened action-potential duration & accelerated cardiac repolarization

Guinea Pig Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. data suggest that CO induces arrhythmias in guinea pig cardiac myocytes via the ONOO(-)-mediated inhibition of Kv11.1 (show KCNV2 Proteins) K(+) channels

Mouse (Murine) Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. histone H4 hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (Kcnj2 (show KCNJ2 Proteins), Kcnj3 (show KCNJ3 Proteins), Kcnj5 (show KCNJ5 Proteins), Kcnj11 (show KCNJ11 Proteins), and Kcnh2)

  2. Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 (show NKX2-5 Proteins) regulates the gene encoding Kcnh2 channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 (show NKX2-5 Proteins) dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies

  3. Report altered protein trafficking/function of mouse ERG K(+) channel clones.

  4. Enhancement of HERG protein expression through Hsp90 (show HSP90 Proteins) inhibition of CHIP binding might be a novel therapeutic strategy for long QT syndrome 2 caused by trafficking abnormalities of HERG proteins.

  5. The findings of this study suggested that MERG1a may not modulate Murf1 (show TRIM63 Proteins) expression through the AKT (show AKT1 Proteins)/FOXO (show FOXO3 Proteins) pathway.

  6. Data indicate presence of KCNH2 in left/right atria & indicate functional interaction between KCNH2 & KCNA5 (show KCNA5 Proteins). Kinetic analyses confirm KCNH2 as "rapid" and KCNA5 (show KCNA5 Proteins) as "ultra rapid" potassium channels.

  7. Knockdown of mERG1 transcripts with small interfering RNA (siRNA) dramatically reduced I (Kr) amplitude, confirming the molecular link of mERG1 and I (Kr) in HL-1 (show ASGR1 Proteins) cells.

  8. The LQT2 missense mutations G601S and N470D hERG exhibited altered protein trafficking in mouse cardiomyocytes.

  9. ERG1 B is necessary for I(Kr) expression in the surface membrane of adult myocytes. Knockout of ERG1 B predisposes mice to episodic sinus bradycardia.

  10. erg1 gene expression pattern in the developing embryo.

Rabbit Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. In transgenic long QT syndrome rabbits, Kv11.1 channel activation shortens the cardiac activation potential duration.

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Protein Profile

Protein Summary

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.

Gene names and symbols associated with KCNH2

  • potassium voltage-gated channel subfamily H member 2 (KCNH2)
  • potassium voltage-gated channel subfamily H member 2 (Kcnh2)
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (Kcnh2)
  • potassium voltage-gated channel subfamily H member 6 (KCNH6)
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2)
  • AI326795 protein
  • cerg protein
  • derg protein
  • erg protein
  • erg1 protein
  • gp-erg protein
  • HERG protein
  • HERG1 protein
  • KCNH2 protein
  • Kv11.1 protein
  • LQT protein
  • Lqt2 protein
  • M-erg protein
  • Merg1 protein
  • merg1a protein
  • merg1b protein
  • SQT1 protein

Protein level used designations for KCNH2

ERG-1 , H-ERG , eag homolog , eag-related protein 1 , ether-a-go-go-related gene potassium channel 1 , ether-a-go-go-related potassium channel protein , ether-a-go-go-related protein 1 , hERG-1 , potassium voltage-gated channel subfamily H member 2 , voltage-gated potassium channel subunit Kv11.1 , potassium voltage-gated channel, subfamily H (eag-related), member 2 , potassium channel protein ERG , potassium voltage-gated channel subfamily H member 2-like , c-ERG , eag related protein 1 , ether-a-go-go related gene potassium channel 1 , MERG , ether a go-go related , RERG , r-ERG , ERG1 , ra-erg , ventricular ERG K+ channel subunit , voltage-gated potassium channel 11.1 , voltage-gated potassium channel, subfamily H, member 2 , HERG protein

GENE ID SPECIES
3757 Homo sapiens
463894 Pan troglodytes
100064000 Equus caballus
100135563 Cavia porcellus
100413935 Callithrix jacchus
100447585 Pongo abelii
403761 Canis lupus familiaris
16511 Mus musculus
117018 Rattus norvegicus
100009242 Oryctolagus cuniculus
414871 Gallus gallus
100858122 Gallus gallus
100523293 Sus scrofa
539971 Bos taurus
Selected quality suppliers for Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteins (KCNH2)
Did you look for something else?