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The protein encoded by PDSS1 is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain.
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Data show that expression of either dlp1 or dps1 recovered the thermo-sensitive growth of an E. coli ispB(R321A) mutant and restored IspB activity and production of Coenzyme Q-8.
murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (mSPS1) and hDLP1 (show PDSS2 Proteins) (mDLP1 (show PDSS2 Proteins))
A deletirious mutation D308E that causes severe ubiquinone deficiency was identified in PDSS1.
murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (mSPS1) and hDLP1 (show PDSS2 Proteins) (mDLP1) [DLP1 (show CSRP2 Proteins)]
In contrast to other plastochromanol-8 biosynthetic mutants, neither the single atsps knock-outs nor the atsps1 atsps2 double knock-out displayed any defects in tocopherols accumulation or germination.
The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency.
all-trans-decaprenyl-diphosphate synthase subunit 1
, coenzyme Q1 homolog
, decaprenyl pyrophosphate synthase subunit 1
, decaprenyl-diphosphate synthase subunit 1
, polyprenyl pyrophosphate synthetase
, subunit 1 of decaprenyl diphosphate synthase
, trans-prenyltransferase (TPT)
, trans-prenyltransferase 1
, decaprenyl pyrophosphate synthetase subunit 1
, solanesyl-diphosphate synthase subunit 1
, subunit 1 of solanesyl diphosphate synthase
, decaprenyl diphdsphate synthase subunit1
, prenyl diphosphate synthase, subunit 1
, COenzyme Q (ubiquinone) biosynthesis family member (coq-1)-like