Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) ELISA Kits

The protein encoded by PLOD2 is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. Additionally we are shipping PLOD2 Antibodies (49) and PLOD2 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse PLOD2 PLOD2 26432 Q9R0B9
Anti-Rat PLOD2 PLOD2 300901  
PLOD2 5352 O00469
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Top PLOD2 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 2.34 pg/mL 9.375-600 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details

More ELISA Kits for PLOD2 Interaction Partners

Mouse (Murine) Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) interaction partners

  1. Data suggest a pro-metastatic GATA3 Transcription Factor (GATA3)- lysyl hydroxylases (LHs) axis for lung cancer, supporting the notion that targeting LHs may be useful for treating lung cancer.

  2. FKBP65 regulates LH2-mediated collagen cross-linking.

  3. The finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2 functions solely on the endoplasmic reticulum and could also have important implications for cancer biology.

  4. Authors propose that lysyl hydroxylase 2, and the subsequent increase in pyridinoline cross-links, is responsible for the persistent fibrosis in experimental osteoarthritis.

  5. Lysyl hydroxylase-2b directs collagen cross-linking pathways through its action on telopeptidyl lysine residues.

  6. LH2b catalyzes post-translational modification of collagen in collagen matrix formation and mineralization in bone.

  7. analysis of the specific regulation for the expression of LH isoforms as well as for alternative splicing of LH2 during embryogenesis and in different tissues

  8. TIA1 and TIAL1 regulate the alternate splicing of lysyl hydroxylase 2

Human Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) interaction partners

  1. Expanding the Clinical Spectrum of Phenotypes Caused by Pathogenic Variants in PLOD2.

  2. adipocyte-derived IL-6 and leptin promote PLOD2 expression by activating the JAK/STAT3 and PI3K/AKT signaling pathways

  3. High PLOD2 expression is associated with Epithelial-Mesenchymal Transition and Chemoresistance in Biliary Tract Cancer.

  4. High PLOD2 expression is associated with Epithelial-Mesenchymal Transition and Chemoresistance in Biliary Tract Cancer.

  5. Mutations in PLOD2 cause Bruck Syndrome

  6. High PLOD2 expression is associated with peritoneal dissemination in gastric cancer.

  7. Findings suggest that Acanthamoeba polyphaga mimivirus L230 co-evolved with human collagen lysyl hydroxylases (LHs).

  8. Gain- and loss-of-function studies and orthotopic implantation metastasis model pinpointed that PLOD2 promotes NSCLC metastasis directly by enhancing migration and indirectly by inducing collagen reorganization.

  9. knockdown of endogenous PLOD2 suppresses glioma cell proliferation, migration and invasion through modulating multiple EMT-associated factors via inactivation of PI3K/AKT signaling.

  10. Only the mechanisms of PLOD2 regulated by HIF-1alpha, TGF-beta and microRNA-26a/b have been elaborated.

  11. Hypoxia upregulated PLOD2 protein in U87 and U251 human glioma cell lines.

  12. This study reports for the first time the expression of PLOD2 in Brain Arteriovenous Malformations and suggests a potential role of PLOD2 in brain Arteriovenous Malformations pathophysiology.

  13. FKBP65 is linked to pyridinoline cross-linking by specifically mediating the dimerization of LH2.

  14. Elevated fasting and postprandial C-terminal telopeptide after Roux-en-Y gastric bypass confers an increased risk of bone loss on recipients.

  15. PLOD2, which is associated with the stiffness of the extracellular matrix, was directly regulated by miR-26a-5p and miR-26b-5p and may be a good prognostic marker in patients with BC

  16. The finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2 functions solely on the endoplasmic reticulum and could also have important implications for cancer biology.

  17. Results show that miR-26a and miR-26b were significantly downregulated in renal cell carcinoma clinical specimens and appeared to function as tumor suppressors through regulation of collagen cross-linking enzymes, LOXL2 and PLOD2, both of which function as oncogenes in this disease.

  18. findings reveal that TGFbeta1 induces a SP1- and SMAD3-dependent recruitment of histone modifying enzymes to the PLOD2 promoter other than the currently known TGFbeta1 downstream co-activators and epigenetic modifications

  19. LH2 enhances the metastatic properties of tumor cells and functions as a regulatory switch that controls the relative abundance of biochemically distinct types of collagen cross-links in the tumor stroma.

  20. TGFbeta induced PLOD2/LH2 expression in human synovial osteoarthritic fibroblasts through ALK5 signaling.

PLOD2 Antigen Profile

Antigen Summary

The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with PLOD2

  • procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 (Plod2) antibody
  • procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) antibody
  • D530025C14Rik antibody
  • LH2 antibody
  • Plod-2 antibody
  • TLH antibody

Protein level used designations for PLOD2

lysyl hydroxylase 2 , procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 , LH2 , Procollagen-lysine 2-oxoglutarate 5-dioxygenase (Lysine hydroxylase) 2 , Procollagen-lysine, 2-oxoglutarate 5-dioxygenase (Lysine hydroxylase) 2 , lysine hydroxylase 2 , lysyl hydroxlase 2 , telopeptide lysyl hydroxylase , procollagen-lysine 2-oxoglutarate 5-dioxygenase 2

GENE ID SPECIES
26432 Mus musculus
300901 Rattus norvegicus
5352 Homo sapiens
641354 Sus scrofa
533642 Bos taurus
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