anti-Prodynorphin (PDYN) Antibodies

The protein encoded by PDYN is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. Additionally we are shipping PDYN Kits (10) and PDYN Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDYN 5173 P01213
PDYN 18610  
PDYN 29190  
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Top anti-PDYN Antibodies at

Showing 10 out of 91 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PDYN Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Hela cell lysate 100 μL 2 to 3 Days
Human Rabbit Un-conjugated WB WB Suggested Anti-Pdyn Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate WB Suggested Anti-Pdyn  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control:.93T cell lysate 100 μL 2 to 3 Days
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using PDYN antibody. Immunohistochemistry of paraffin-embedded rat brain using PDYN antibody. 200 μL 12 to 14 Days
Human Mouse Un-conjugated IP, ELISA, WB Detection limit for recombinant GST tagged PDYN is 0.1 ng/ml as a capture antibody. Western Blot analysis of PDYN expression in transfected 293T cell line by PDYN monoclonal antibody (M01), clone 2E12.Lane 1: PDYN transfected lysate(28.4 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
Human Rabbit Un-conjugated IHC (fro), IHC (p), RIA   0.1 mL 6 to 8 Days
Guinea Pig Rabbit Un-conjugated IHC (fro), RIA   0.1 mL 6 to 8 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-Dynorphin A/Proenkephalin B Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 14 to 21 Days
Human Rabbit Un-conjugated WB Prodynorphin antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days

Top referenced anti-PDYN Antibodies

  1. Human Polyclonal PDYN Primary Antibody for WB - ABIN6746613 : Agarwal, Baek, Jeon, Miyamoto, Ueno, Yoon: Stimulation of transcript elongation requires both the zinc finger and RNA polymerase II binding domains of human TFIIS. in Biochemistry 1991 (PubMed)
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  2. Human Polyclonal PDYN Primary Antibody for WB - ABIN4894853 : Jiang, Wang, Li, Mo, Song, Tang, Feng: Electroacupuncture relieves labour pain and influences the spinal dynorphin/κ-opioid receptor system in rats. in Acupuncture in medicine : journal of the British Medical Acupuncture Society 2016 (PubMed)

  3. Chemical Monoclonal PDYN Primary Antibody for IHC (fro), RIA - ABIN2475324 : Gómez-Garcés, Rodríguez-Tudela, Castilla, Soriano: [Mycobacteria and inoculation of guinea pigs. Is it a useful diagnostic procedure?]. in Enfermedades infecciosas y microbiología clínica 1991 (PubMed)
    Show all 3 Pubmed References

  4. Mouse (Murine) Polyclonal PDYN Primary Antibody for IHC (fro) - ABIN2475325 : Neal, Newman et al.: Prodynorphin peptide distribution in the forebrain of the Syrian hamster and rat: a comparative study with antisera against dynorphin A, dynorphin B, and the C-terminus of the prodynorphin precursor ... in The Journal of comparative neurology 1989 (PubMed)
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  5. Human Polyclonal PDYN Primary Antibody for IHC (fro), IHC (p) - ABIN2473381 : Zardetto-Smith, Moga, Magnuson, Gray: Lateral hypothalamic dynorphinergic efferents to the amygdala and brainstem in the rat. in Peptides 1989 (PubMed)
    Show all 4 Pubmed References

More Antibodies against PDYN Interaction Partners

Human Prodynorphin (PDYN) interaction partners

  1. Our findings demonstrate that PDYN expression in neurons of human dorsolateral prefrontal cortex is associated with differential methylation of its promoter.

  2. PDYN and OPRK1 showed transcriptionally coordinated pattern that was significantly different between alcoholics and controls.

  3. Absolute expression levels of PDYN were lower compared to those of OPRK1, suggesting that PDYN expression is a limiting factor in the DYN/KOR signaling, and that the PDYN downregulation diminishes efficacy of DYN/KOR signaling in dorsolateral prefrontal cortex of human alcoholics.

  4. Study investigated transcriptional regulation of Bipolar Disorder (BD) selected target genes by DNA methylation in peripheral blood mononuclear cells of patients with BD type I (BD-I) and type II (BD-II). The analysis of gene expression revealed prodynorphin (PDYN) mRNA levels significantly reduced in subjects with BD-II but not in those with BD-I.

  5. Genetic and epigenetic factors within PDYN are related to risk for alcoholism.

  6. These results indicate that KOR can form a heterodimer with B2R and this leads to increased protein kinase A activity by the CREB signaling pathway, leading to a significant increase in cell proliferation.

  7. This study found a significant haplotype-by-sex interaction, suggesting association with alcohol dependence in males but not females. The findings suggest that sex-dependent effects of PDYN variants in alcohol dependence are phenotype-specific.

  8. PDYN gene promoter polymorphism might contribute to familial-risk temporal lobe epilepsy. (Review, meta-analysis)

  9. The results demonstrate that DYN 1-17 and certain N-terminal fragments, produced in an inflamed environment, play an anti-inflammatory role by inhibiting NF-kappaB/p65 translocation.

  10. Enhanced event-related potentials amplitudes suggest a hyper-active performance monitoring system in high PDYN expression individuals, and this might also be an indicator of a higher risk for internalizing disorders

  11. This study generated the first mouse model for SCA23 and shown that mice expressing PDYN-R212W recapitulate many characteristics of the human phenotype of SCA23

  12. The present findings revealed a male-limited association between VNTR polymorphism and heroin dependence risk.

  13. Studied differential DNA-protein interactions of PDYN and OPRK1 SNPs significantly associated with alcohol dependence.

  14. A genetic polymorphism of the endogenous opioid dynorphin modulates monetary reward anticipation in the corticostriatal loop.

  15. REST represses PDYN expression in SH-SY5Y cells and the adult human brain and may have implications for mental health and brain/mental disorders.

  16. This study demonistratedn that Neurocognitive and neuroinflammatory correlates of PDYN mRNA expression in the anterior cingulate in postmortem brain of HIV-infected subjects.

  17. Data indicate that the minor allele of PDYN rs2281285 was associated with an increased risk of drinking to avoid/escape unwanted emotional or somatic events.

  18. To investigate the frequency of SCA23 among the Chinese Han population, we performed polymerase chain reaction (PCR) and DNA direct sequencing of the PDYN gene in 305 unrelated ataxia patients

  19. Our data corroborates recent work that also showed that PDYN mutations only account for a small percentage (~0.1 %) of European spinocerebellar ataxia cases.

  20. PDYN mRNA expression was reduced in the postmortem human amygdala nucleus of the periamygdaloid cortex in both heroin abusers & major depressive disorder subjects.

Mouse (Murine) Prodynorphin (PDYN) interaction partners

  1. Study found that locally-released neurotensin (NT) and dynorphin (Dyn) antagonistically regulated central amygdala (CeA) inhibitory inputs onto oval bed nucleus of the stria terminalis (ovBNST) neurons. NT and Dyn respectively increased and decreased CeA-toovBNST inhibitory inputs through NT receptor 1 and kappa opioid receptor. NT and Dyn mRNAs were highly co-localized in ovBNST neurons.

  2. Mechanical allodynia produced by monosodium iodoacetate (MIA) was enhanced in mice lacking KOR or PDYN gene. In contrast with the nociceptive manifestations induced by osteoarthritis, the increased microglial expression on the lumbar section of the spinal cord after MIA administration was similar in KOR-KO, PDYN-KO and WT littermates. Moreover, anhedonic- and anxiolytic-like states were revealed after MIA administration.

  3. steroidal environment and energy state negatively regulate kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn) gene expression.

  4. These pathways are consistent with previously reported behavioral and biochemical phenotypes that typify mice lacking ENT1. Moreover, we validated decreased expression of the SNARE complex protein VAMP1 (synaptobrevin-1) in the dHip as well as decreased expression of pro-dynorphin (PDYN), neuroendocrine convertase (PCSK1), and Leu-Enkephalin (dynorphin-A) in the nucleus accumbens

  5. DYN-A(2-17) interacts with Orexin A in the paraventricular hypothalamic nucleus to modulate food intake in mice.

  6. We found potential links between the alterations in expression of Tsc22d3, Nfkbia and Pdyn, and different aspects of susceptibility to stress.

  7. This study identify that photostimulation of dyn-expressing cells in discrete subregions within the NAcSh drive opposing motivational behavioral states

  8. The results of this study indicated that PDYN have a differential role in cue-induced reinstatement of cocaine-seeking behavior.

  9. Double NPY and dynorphin deletion resulted in heavier mice, with increased adiposity, despite no significant changes in food intake or UCP-1 activity.

  10. These results suggest that elevated dynorphin expression occurring during aging and Alzheimer's disease may mediate cognitive deficits by altering the glutamatergic system integrity.

  11. These findings identify a unique cellular process by which orexin can occlude the reward threshold-elevating effects of coreleased dynorphin and thereby act in a permissive fashion to facilitate reward.

  12. When released from spinal inhibitory interneurons, dynorphin is a key modulator of pruritus.

  13. Data suggest that activation of neurokinin 3 and kappa-opioid receptors (NK3R and KOR) excites and inhibits kisspeptin, neurokinin B (NKB), and dynorphin (KNDy neurons).

  14. The results of this study suggested that elevated Pdyn expression during normal aging reduces mGluR expression and signaling, which in turn impairs cognitive functions and increases anxiety.

  15. Thus the dynorphin system, acting via neuropeptide y, may represent a pathway by which higher processes including stress, reward/addiction and depression influence skeletal metabolism

  16. Endogenous dynorphin plays a critical role in protecting dopaminergic neurons through its anti-inflammatory effects.

  17. sex and genetic background have an effect on anxiety-related and stress-induced behaviour of prodynorphin-deficient mice

  18. A role of dynorphin and kappa opioid receptor signaling are established in fear extinction that resulted in impaired extinction of context-specific fear response.

  19. The results suggest that deletion of the PDYN gene increased vulnerability for ethanol consumption by altering, PENK, TH and DAT gene expression, and opioid receptor function in brain areas closely related to ethanol reinforcement.

  20. Activation of the dynorphin/kappa-opioid receptor system by forced swim stress may enhance nicotine-seeking behaviors. dynorphin release or

Cow (Bovine) Prodynorphin (PDYN) interaction partners

  1. The investigation of Dyn A 1-17 metabolism at the blood-brain barrier (BBB) is important since the metabolites exhibit unique biological functions compared to the parent compound.

Xenopus laevis Prodynorphin (PDYN) interaction partners

  1. The Xen-dorphin prohormone is a new opioid-like prohormone distinct from proenkephalin and prodynorphin.

Pig (Porcine) Prodynorphin (PDYN) interaction partners

  1. Porcine follicular cells (especially granulosa cells) may produce opioid peptides and that gonadotropins may modulate gene expression of their precursors in these cells.

  2. The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK) and prodynorphin (PDYN) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.

Rhesus Monkey Prodynorphin (PDYN) interaction partners

  1. Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence.

PDYN Antigen Profile

Protein Summary

The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with anti-Prodynorphin (PDYN) Antibodies

  • prodynorphin (pdyn) antibody
  • prodynorphin (PDYN) antibody
  • prodynorphin (Pdyn) antibody
  • prodynorphin L homeolog (pdyn.L) antibody
  • prodynorphin S homeolog (pdyn.S) antibody
  • ADCA antibody
  • Dyn antibody
  • olpa antibody
  • olpb antibody
  • PDYN antibody
  • penkb antibody
  • SCA23 antibody
  • wu:fj38c03 antibody
  • Xen-dorphin antibody
  • XOLPA antibody
  • XOLPB antibody

Protein level used designations for anti-Prodynorphin (PDYN) Antibodies

Beta-neoendorphin-dynorphin , beta-neoendorphin-dynorphin , leu-enkephalin , leumorphin , neoendorphin-dynorphin-enkephalin prepropeptide , preprodynorphin , preproenkephalin B , proenkephalin-B , rimorphin , proenkephalin B , proenkephalin-B preproprotein , prodynorphin , dorphin A , dorphin B , fj38c03 , proenkephalin-b

100195894 Salmo salar
5173 Homo sapiens
18610 Mus musculus
29190 Rattus norvegicus
281385 Bos taurus
403367 Xenopus laevis
403368 Xenopus laevis
414850 Danio rerio
445529 Sus scrofa
469860 Pan troglodytes
485808 Canis lupus familiaris
716341 Macaca mulatta
100135596 Cavia porcellus
100294654 Ovis aries
100341339 Oryctolagus cuniculus
100528666 Ictalurus punctatus
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