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Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.. Additionally we are shipping Progesterone Immunomodulatory Binding Factor 1 Antibodies (77) and Progesterone Immunomodulatory Binding Factor 1 Kits (11) and many more products for this protein.
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Human PIBF1 Protein expressed in Wheat germ - ABIN1314997
González-Arenas, Valadez-Cosmes, Jiménez-Arellano, López-Sánchez, Camacho-Arroyo: Progesterone-induced blocking factor is hormonally regulated in human astrocytoma cells, and increases their growth through the IL-4R/JAK1/STAT6 pathway. in The Journal of steroid biochemistry and molecular biology 2014
B cell deficiency in mice resulted in a lower uterine level of active progesterone-induced blocking factor 1 (PIBF1), and susceptibility to preterm labor after inflammation. B cells are a significant producer of PIBF1 in mouse uterus in late gestation.
The relative abundance of PIBF, LGALS1 (show LGALS1 Proteins), LGALS3 (show LGALS2 Proteins), LGALS3BP (show LGALS3BP Proteins), and LGALS9 (show LGALS9 Proteins) mRNA would display a differential expression pattern in the endometrium.
blood and placental tissue level expression of PIBF is concordant and correlates with both progesterone receptor (show PGR Proteins) expression status as well as final pregnancy outcome
this study shows that preterm birth may be predictable at 24-28 gestational week by lower than normal pregnancy PIBF values
B cells are a significant producer of PIBF1 in human choriodecidua in late gestation. Preterm labor was associated with a lower level of active PIBF1 in late gestation choriodecidua.
PIBF plays a role in both normal pregnancy and tumor biology.
PIBF promotes proliferation, migration, and invasion of human glioblastoma cells.
These data show that exposure to an allogeneic stimulus is not needed to cause a marked rise in PIBF, merely progesterone alone is sufficient.
Maternal serum progesterone-induced blocking factor (PIBF) in the prediction of preterm birth.
Progesterone-induced blocking factor is hormonally regulated in human astrocytoma cells, and increases their growth through the IL-4R/JAK1 (show JAK1 Proteins)/STAT6 (show STAT6 Proteins) pathway
decreased kisspeptin and PIBF expressions in trophoblasts and deciduas are associated with recurrent spontaneous abortion
Data indicate that silencing of progesterone-induced blocking factor (PIBF) increased invasiveness as well as MMP-2 (show MMP2 Proteins),-9 secretion of HTR8/SVneo trophoblast, and decreased those of HT-1080 (show CDC123 Proteins) cells.
Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.
progesterone-induced blocking factor 1
, progesterone-induced-blocking factor 1
, progesterone immunomodulatory binding factor 1
, progesterone-induced-blocking factor 1-like