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Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.. Additionally we are shipping PAQR3 Proteins (3) and many more products for this protein.
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Data suggest that expression of PAQR3 is down-regulated in glioma tissues and cell lines; PAQR3 overexpression suppresses cell migration of glioma cells, suppresses invasivness of glioma in xenograft experiments, and prevents epithelial-mesenchymal transition.
our study pinpoints that PAQR3 functions as an adaptor protein to promote Nrf2 (show GABPA Antibodies)-Keap1 (show KEAP1 Antibodies) complex formation, thereby modulating the Nrf2 (show GABPA Antibodies)-Keap2 pathway and playing an important role in controlling antioxidant response of the cell
This finding reveals a new mode of regulation of mTORC1 signaling and autophagy by PAQR3 in response to alterations of amino acids.
we demonstrated that overexpression of PAQR3 suppresses cell proliferation, migration, and invasion in esophageal cancer in vitro and in vivo.
The expression of PAQR3 protein significantly decreased in lung cancer.
our results suggested that the aberrant methylation of PAQR3 underlies its downregulation in breast cancer and our data indicated that epigenetic silencing of PAQR3 gene expression by promoter hypermethylation may play an important role in breast cancer
PAQR3 plays a tumor suppressive role in laryngeal squamous cell carcinoma
A novel role for the newly characterized, Golgi-localized PAQR3 in regulating heterotrimeric G-proteins at the non-canonical subcellular location of the Golgi.
findings not only pinpoint that Twist1 (show TWIST1 Antibodies) mediates the modulatory function of PAQR3 on EMT (show ITK Antibodies) and metastasis but also suggest that targeting Twist1 (show TWIST1 Antibodies) is a promising strategy to control metastasis of tumors with downregulation of PAQR3
PAQR3 regulates cholesterol homeostasis by anchoring Scap/SREBP to the Golgi and disruption of such function reduces cholesterol biosynthesis.
PAQR3 controls autophagy by integrating AMPK (show PRKAA1 Antibodies) signaling to enhance ATG14L-associated PI3K activity
This study reveals that PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin (show LEP Antibodies) signaling.
PAQR3 negatively regulates insulin (show INS Antibodies) signaling by shunting cytosolic p110alpha (show PIK3CA Antibodies) to the Golgi apparatus while competing with p85 (show ECM1 Antibodies) subunit in forming a PI3K complex with p110alpha (show PIK3CA Antibodies).
Loss of PAQR3 is associated with tumorigenesis of colorectal cancers.
reveal a paradigm of spatial regulation of Raf (show RAF1 Antibodies) kinase by RKTG via sequestrating Raf-1 (show RAF1 Antibodies) to the Golgi apparatus and thereby inhibiting the ERK (show EPHB2 Antibodies) signaling pathway.
RKTG has a suppressive activity in chemical carcinogen-induced mitogenesis and tumor formation in mouse skin.
Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.
Raf kinase trapping to Golgi
, progestin and adipoQ receptor family member 3