Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) Proteins (PDCD4)

PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Additionally we are shipping PDCD4 Antibodies (264) and PDCD4 Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDCD4 27250 Q53EL6
PDCD4 18569 Q61823
PDCD4 64031 Q9JID1
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Top PDCD4 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 6 to 8 Days
$364.64
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$385.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$3,314.67
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,322.00
Details
Yeast Orang-Utan His tag   1 mg Log in to see 60 to 71 Days
$3,322.00
Details
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$225.00
Details
Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 2 to 3 Days
$5,723.08
Details

PDCD4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaction Partners

Human Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. In the high malignant group the PDCD4 mRNA and PDCD5 (show PDCD5 Proteins) mRNA expressions were significantly decreased compared with the low malignant group and the control group. PDCD4 mRNA and PDCD5 (show PDCD5 Proteins) mRNA expressions are promising targets for the diagnosis and treatment of glioma.

  2. miR (show MLXIP Proteins)-21 may promote salivary adenoid cystic carcinoma progression via PDCD4 and PTEN down-regulation and Bcl-2 (show BCL2 Proteins) up-regulation.

  3. The expression of PDCD4 is decreased in cervical cancer tissues, compared to miR (show MLXIP Proteins)-150 which is increased.

  4. Our study demonstrated that lncRNA-XIST, which acts as a miRNA sponge, impedes miR (show MLXIP Proteins)-21-5p to maintain the expression of PDCD4, which contributes to the progression of osteosarcoma (OS). Our findings suggest that the newly identified XIST/miR (show MLXIP Proteins)-21-5p/PDCD4 axis could be a potential biomarker or therapeutic target for OS.

  5. miR206 promoted the onset of SANFH by inducing apoptosis and suppressed the proliferation of osteoblasts, which was dependent on the inhibition of PDCD4.

  6. Results found PDCD4 as a target gene of miR (show MLXIP Proteins)-93 and miR (show MLXIP Proteins)-93 could down-regulate the expression of PDCD4 by directly targeting its 3'-UTR. The re-expression of PDCD4 could attenuate the hepatocellular carcinoma (HCC (show FAM126A Proteins)) cell invasion and migration induced by miR (show MLXIP Proteins)-93, while the knockdown of PDCD4 would promote HCC (show FAM126A Proteins) cell migration and invasion via the EMT (show ITK Proteins) pathway.

  7. Reduced expression of PDCD4 was found in decidual and chorionic tissues, and peripheral blood mononuclear cells from patients with missed abortion.

  8. miR503 promotes tumour growth and invasion by directly targeting PDCD4.

  9. A novel mechanism of Pdcd4 action as a translation inhibitor and tumor suppressor has been proposed.

  10. Taken together, this study highlights an important role for miR (show MLXIP Proteins)-23a/b as oncomiRs in gastric cancer through the inhibition of PDCD4 translation. These findings may shed new light on the molecular mechanism of gastric carcinogenesis and provide a new avenue for gastric cancer treatment.

Mouse (Murine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. MEG3 functions as a competing endogenous RNAs (ceRNAs) and competes with PDCD4 mRNA for directly binding to miR (show MLXIP Proteins)-21, which mediates ischemic neuronal death.

  2. In colorectal cancer tissues, the Sin1 (show MAPKAP1 Proteins) protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 (show MAPKAP1 Proteins) protein level but not mRNA level in colorectal cancer.

  3. -induced expression of PDCD4 is associated with increased beta cell death.

  4. miR (show MLXIP Proteins)-155 not only directly inhibited SOCS1 (show SOCS1 Proteins) expression, but also increased the expression of p-STAT (show STAT1 Proteins) and PDCD4, as well as the production of proinflammation mediators IL-6 (show IL6 Proteins) and TNF-alpha (show TNF Proteins) in atherogenesis

  5. our data suggest that Pdcd4 as a crucial regulator in SGs (show SKI Proteins) induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.

  6. Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10 (show IL10 Proteins).

  7. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) Pathway.

  8. Study found that miR-16 (show GDE1 Proteins) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (show NFKB1 Proteins) and MAPK (show MAPK1 Proteins) pathways.

  9. Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.

  10. PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.

Zebrafish Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. miR (show MYLIP Proteins)-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4

Pig (Porcine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB (show NFKB1 Proteins)/ TNF-alpha (show TNF Proteins) pathway in cardiomyocytes.

PDCD4 Protein Profile

Protein Summary

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PDCD4

  • programmed cell death 4 (PDCD4)
  • programmed cell death 4 (Pdcd4)
  • programmed cell death 4b (pdcd4b)
  • programmed cell death 4 L homeolog (pdcd4.L)
  • programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4)
  • programmed cell death 4 (pdcd4)
  • cb45 protein
  • D19Ucla1 protein
  • Dug protein
  • h731 protein
  • Ma3 protein
  • MGC69337 protein
  • PDCD4 protein
  • sb:cb45 protein
  • Tis protein
  • wu:fc84b08 protein

Protein level used designations for PDCD4

neoplastic transformation inhibitor protein , nuclear antigen H731 , programmed cell death protein 4 , protein 197/15a , protein MA-3 , topoisomerase-inhibitor suppressed protein , death up-regulated gene protein , death-upregulated , protein I11/6 , programmed cell death 4 (neoplastic transformation inhibitor) , programmed cell death protein 4-like

GENE ID SPECIES
27250 Homo sapiens
18569 Mus musculus
64031 Rattus norvegicus
321061 Danio rerio
380222 Xenopus laevis
506724 Bos taurus
374191 Gallus gallus
407925 Xenopus (Silurana) tropicalis
450735 Pan troglodytes
477818 Canis lupus familiaris
695345 Macaca mulatta
100021762 Monodelphis domestica
100080517 Ornithorhynchus anatinus
100354557 Oryctolagus cuniculus
100413000 Callithrix jacchus
100469480 Ailuropoda melanoleuca
100584426 Nomascus leucogenys
100157112 Sus scrofa
100173014 Pongo abelii
100723476 Cavia porcellus
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