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Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. Additionally we are shipping PNRC2 Proteins (10) and and many more products for this protein.
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Rat (Rattus) Polyclonal PNRC2 Primary Antibody for WB - ABIN4893631
Graber, Freemantle, Anadolu, Hébert-Seropian, MacAdam, Shin, Hoang, Alain, Lacaille, Sossin: UPF1 Governs Synaptic Plasticity through Association with a STAU2 RNA Granule. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2017
UPF1 interacts with PNRC2 and that it triggers 5'-3' exonucleolytic decay of reporter transcripts in tethering assays. PNRC2 is probably an important mRNA decapping factor but that it does not appear to be required for nonsense-mediated mRNA decay.
GR and PNRC2 interact in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation
PNRC2 acts in synergy with Dcp1a to stimulate the decapping activity of Dcp2 by bridging the interaction between Dcp1a and Dcp2.
Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis.
PNRC2 plays an essential role in mammalian Nonsense-mediated mRNA decay (NMD), mediating the interaction between the NMD machinery and the decapping complex.
Pnrc2 promotes 3'UTR-mediated decay of developmentally-regulated segmentation clock transcripts.
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1/rent1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).