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Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. Additionally we are shipping PNRC2 Antibodies (20) and and many more products for this protein.
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UPF1 (show UPF1 Proteins) interacts with PNRC2 and that it triggers 5'-3' exonucleolytic decay of reporter transcripts in tethering assays. PNRC2 is probably an important mRNA decapping factor but that it does not appear to be required for nonsense-mediated mRNA decay.
GR and PNRC2 interact in a ligand-dependent manner to recruit UPF1 (show UPF1 Proteins) for rapid mRNA degradation
PNRC2 acts in synergy with Dcp1a (show DCP1A Proteins) to stimulate the decapping activity of Dcp2 (show DCP2 Proteins) by bridging the interaction between Dcp1a (show DCP1A Proteins) and Dcp2 (show DCP2 Proteins).
Not only PNRC2 but also the corepressor TLE1 (show TLE1 Proteins) functioned as ERRgamma (show ESRRG Proteins) coactivator in a reporter gene analysis.
PNRC2 plays an essential role in mammalian Nonsense-mediated mRNA decay (NMD), mediating the interaction between the NMD machinery and the decapping complex.
The finding that the PNRC2 promoter is activated by NFY and repressed by E2F1 (show E2F1 Proteins) indicates that in addition to functioning as nuclear receptor coactivator, PNRC2 may also play a role in the cell cycle.
Study provides evidence that PNRC2 plays one or more important roles in controlling the energy balance between energy storage and energy expenditure. PNRC2 may be a new target in the treatment of obesity and related metabolic diseases.
Pnrc2 promotes 3'UTR-mediated decay of developmentally-regulated segmentation clock transcripts.
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1/rent1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).