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PTGER2 encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Additionally we are shipping PTGER2 Antibodies (106) and PTGER2 Kits (26) and many more products for this protein.
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Prostaglandin E receptor subtype 2 (EP2 (show SPAG11A Proteins); Ptger2) deficiency suppressed nuclear factor kappaB (NF-kappaB (show NFKB1 Proteins)) activation in intracranial arteries 4 and 8 weeks after intracranial aneurysm induction.
neuronal EP2 receptor activation by PGE2 protects brain against intracerebral hemorrhage injury in middle-aged mice through its anti-inflammatory and anti-oxidant effects and anti-MMP-2 (show MMP2 Proteins)/9 activity
data demonstrate that endogenous PGE2, EP2 (show SPAG11A Proteins) receptors, and EPAC (show RAPGEF3 Proteins) are prerequisites for maximal LPS (show TLR4 Proteins)-induced IL-33 (show IL33 Proteins) expression and that exogenous PGE2 can amplify IL-33 (show IL33 Proteins) production via EP2 (show SPAG11A Proteins) and EP4 (show PTGER4 Proteins) receptors.
The data presented highlight a key role for EP2 (show SPAG11A Proteins) and EP4 (show PTGER4 Proteins) receptors in microvascular leak induced by PGE2.
Exposure of macrophages to cyclooxygenase (COX-2) inhibitors RhoA (show RHOA Proteins) and LA-4 cells to antagonists of prostaglandin E2 (PGE2) receptor , PGD2 (show PTGDS Proteins) receptors or the hepatocyte growth factor (HGF (show HGF Proteins)) receptor c-Met (PHA (show LBR Proteins)-665752), reversed EMT (show ITK Proteins) inhibition by the conditioned medium
EP2 (show SPAG11A Proteins) deficiency in MCs (show SMCP Proteins) augmented TGF-beta1 (show TGFB1 Proteins)-induced fibronectin (FN (show FN1 Proteins)), cyclooxygenase-2 (COX2 (show PTGS2 Proteins)), and CyclinD1 expression. Silencing of EP2 (show SPAG11A Proteins) also strengthened TGF-beta1 (show TGFB1 Proteins)-induced extracellular-signal-regulated kinase 1/2 (show MAPK3 Proteins) (ERK1/2) phosphorylation
autocrine prostaglandin E2 signaling through EP receptors is essential for optimal CD4 (show CD4 Proteins)(+) T-cell activation.
the blockade of EP2 (show SPAG11A Proteins) and EP4 (show PTGER4 Proteins) promotes mouse survival after cryptococcus infection by promoting the production of cytokines via TLR4 (show TLR4 Proteins), as well as the enhanced M1 polarization of alveolar macrophages
COX-2-derived PGE2 inhibits IL-10 expression in brain microglia through a novel EP2- and beta-arrestin-dependent signaling pathway.
Cardiac inflammation is reduced in EP-2 (show SPAG11A Proteins)-/- mice.
PGE2 produced by mesenchymal stem cells contributes to maintenance of self-renewal capacity through EP2 (show SPAG11B Proteins) in an autocrine manner, and PGE2 secretion is down-regulated by cell-to-cell contact.
in breast cancer cells overexpression of S1P3 (show S1PR3 Proteins) and its activation by S1P (show MBTPS1 Proteins) has pro-inflammatory and pro-metastatic potential by inducing COX-2 expression and PGE2 signaling via EP2 (show SPAG11B Proteins) and EP4 (show PTGER4 Proteins).
EP2 (show SPAG11B Proteins) and EP3 (show PTGER3 Proteins) receptors are involved in tolerance induction through IL-10 (show IL10 Proteins) production by tol-DCs.
This is the first report that PGE2 -induced uPAR (show PLAUR Proteins) expression, which stimulates invasiveness of human gastric cancer AGS (show JAG1 Proteins) cells, is mediated by the EP2 receptor-dependent Src (show SRC Proteins)/EGFR (show EGFR Proteins)/JNK1 (show MAPK8 Proteins)/2, Erk1/2/AP-1 (show FOSB Proteins), and Src (show SRC Proteins)/EGFR (show EGFR Proteins)/JNK1 (show MAPK8 Proteins)/2, Erk1/2/NF-kappaB (show NFKB1 Proteins) cascades.
These results indicate that the ICL2 region of the EP2 receptor is its potential interaction site with Galphas (show GNAS Proteins), and that the aromatic side chain moiety at position 143 is a determinant for the accessibility of the ICL2 to the Galphas (show GNAS Proteins) protein.
EP2 (show SPAG11B Proteins) receptors seem to be able to distinguish endogenous ligands PGD2 (show PTGDS Proteins), PGE2 or prostaglandin F2alpha better than DP receptors.
EP2 receptor activation protects against endoplasmic reticulum stress-dependent mitochondrial apoptosis through down-regulation of p53 (show TP53 Proteins).
that the expression of ERG (show ERG Proteins) in prostate cancer is linked to the expression of IL-6 (show IL6 Proteins) mediated by the prostanoid receptor EP2 (show SPAG11B Proteins)
mPGES-1 (show PTGES Proteins) is downregulated via EGR1 (show EGR1 Proteins) and has a role in caffeine inhibition on PGE2 synthesis of HBx hepatocytes
Altered expression of EP2 (show SPAG11B Proteins) in patients with aspirin-exacerbated respiratory disease contributes to deficient induction of IL-1RI, reducing the capacity of IL-1beta (show IL1B Proteins) to increase COX-2 and mPGES-1 (show PTGES Proteins) expression, which results in low PGE2 production
The results indicated that mRNA and protein expression of connective tissue growth factor (CTGF (show CTGF Proteins)), fibroblast growth factor-2 (FGF-2 (show FGF2 Proteins)), interleukin-8 (IL-8 (show IL8 Proteins)), transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Proteins)), matrix metalloproteinase-2 (MMP-2 (show MMP2 Proteins)), and vascular endothelial growth factor A (VEGFA (show VEGFA Proteins)) were up-regulated after PTGER2 activation by corresponding agonist butaprost
Data suggest that lysophosphatidic acid (LPA (show PLG Proteins)) up-regulates expression of SLCO2A1 (show SLCO2A1 Proteins) (prostaglandin [PG] transporter), PTGER2/PTGER4 (show PTGER4 Proteins) (PG receptors EP2 (show SPAG11A Proteins)/EP4 (show PTGER4 Proteins)), and mPGES1 (show PTGES Proteins)/cPGES (show PTGES3 Proteins) (microsomal/cytosolic PG E synthases) in luteal cells.
Data suggest that estradiol up-regulates mRNA and protein expression of 3 prostanoid receptors in oviduct smooth muscle: EP2/PTGER2 (prostaglandin E receptor 2); EP4/PTGER4 (show PTGER4 Proteins) (prostaglandin E receptor 4); and FP/PTGFR (prostaglandin F2alpha receptor (show PTGFR Proteins)).
EP2 (show SPAG11A Proteins) is the major cAMP-generating PGE (show LIPF Proteins)(2) receptor expressed and regulated in the bovine uterus during the estrous cycle and early pregnancy.
COX-2 (show PTGS2 Proteins) and FP receptor (show PTGFR Proteins) contribute via changes in amount and distribution to mechanisms associated with parturition.
Quantitative RT-PCR revealed significant higher expression of EP2 (show SPAG11A Proteins) and EP4 (show PTGER4 Proteins) in the pre-ovulatory phase compared with the luteal phase in the bovine oviduct
This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma.
, prostaglandin E receptor 2 (subtype EP2), 53kDa
, prostaglandin E2 receptor EP2 subtype
, EP2 receptor
, PGE receptor EP2 subtype
, PGE2 receptor EP2 subtype
, prostaglandin E receptor 2 (EP2 subtype)
, prostaglandin E receptor EP2 subtype
, prostaglandin E receptor subtype EP2
, prostanoid EP2 receptor
, PGE receptor, EP2 subtype
, prostaglandin E2 receptor type 2
, prostaglandin E2 receptor subtype EP2