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The protein encoded by PTGES is a glutathione-dependent prostaglandin E synthase. Additionally we are shipping Prostaglandin E Synthase Antibodies (58) and Prostaglandin E Synthase Proteins (6) and many more products for this protein.
Showing 5 out of 22 products:
Human Prostaglandin E Synthase ELISA Kit for Sandwich ELISA - ABIN417308
Yu, Hou, Sun, Liu, Li et al.: Upregulation of C-C chemokine receptor type 7 expression by membrane-associated prostaglandin E synthase-1/prostaglandin E2 requires glycogen synthase kinase 3β-mediated signal transduction in colon ... in Molecular medicine reports 2015
Studied iNOS(inducible nitric oxide synthase (show NOS2 ELISA Kits)) activation thru mPGES-1 (microsomal prostaglandin E synthase-1) signaling driven by EGFR (EGF receptor (show EGFR ELISA Kits)) in cancer progression models.
COX-2 (show COX2 ELISA Kits) and mPGES-1-dependent synthesis of PGE2 contributes to a dedifferentiated aortic smooth muscle cell phenotype.
Several studies provide evidence that the expression of mPGES1 is regulated by a number of transcriptional factors and inducible in conditions of inflammation and hypoxia.[review]
The Genome Wide Area Study, using a phenotyping algorithm for asthma for data mining electronic medical records, identified four asthma susceptibility loci: 6p21.31, 9p21.2, and 10q21.3 in the European American population; and the prostaglandin synthase E gene (PTGES) at 9q34.11 in African Americans. Biologic support exists for genes at the 9p21.2 and 9q34.11 loci TEK (show TEK ELISA Kits), encoding the endothelial tyrosine in animal studies.
C-myc (show MYC ELISA Kits) regulates mPGES1 expression by binding to the proximal promoter. C-myc (show MYC ELISA Kits) transfection in HeLa cells up-regulates mPGES1 mRNA and protein expression.
COX-2 (show COX2 ELISA Kits) and mPGES-1 have roles in arachidonic acid regulation of inflammatory prostaglandin E2 biosynthesis
The identified amino acid residues can act as target sites for the design and development of drug candidates against mPGES-1
These findings support the value of a prognostic and predictive role for mPGES1.
Data show that statins limit hepatic myofibroblasts proliferation via a cyclooxyegnase-2 (COX-2 (show COX2 ELISA Kits)) and microsomal PGE (show LIPF ELISA Kits) synthase-1 (mPGES-1) dependent pathway.
Data show that cyclooxygenase2 (COX2 (show COX2 ELISA Kits))overexpression induces prostaglandin E synthase (PTGES) through early growth response 1 (EGR1 (show EGR1 ELISA Kits)) in colorectal cancer cell lines.
that mPGES-1 exerts a potentially protective effect against renal fibrosis and inflammation induced by unilateral ureteral obstruction in mice
In line with the acetyltransferase activity of p300 (show NOTCH1 ELISA Kits), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (show HDAC3 ELISA Kits) activity maintains PTGES1 expression by recruiting p300 (show NOTCH1 ELISA Kits) to its gene
The findings suggest that COX-2 (show COX2 ELISA Kits)/mPGES-1/PGE2 axis could be activated by albumin (show ALB ELISA Kits) in the proximal tubular cells via a NLRP3 (show NLRP3 ELISA Kits) inflammasome-mediated mechanism and could thus contribute to proteinuria-related renal tubular cell injury.
mPGES-1 overexpression prevents Fas (show FAS ELISA Kits)-induced hepatocyte apoptosis and liver injury through activation of Akt (show AKT1 ELISA Kits) .
The expression of Lcn2 (show LCN2 ELISA Kits) and mPGES-1 is strongly stimulated by lipopolysaccharide (LPS (show TLR4 ELISA Kits)), indicating that Lcn2 (show LCN2 ELISA Kits) mediates LPS (show TLR4 ELISA Kits)-induced inflammation. These findings shed light on the role of Lcn2 (show LCN2 ELISA Kits) during decidualization.
The results show that mPges-1 may be a direct downstream target gene of the P4 receptor (show PGR ELISA Kits).
mPges-1 depletion modestly increased thrombogenesis in LDL-receptor (show LDLR ELISA Kits) knockout mice. This response was markedly further augmented by coincident deletion of the I prostanoid receptor.
Data (including data from studies in knockout mice) suggest interactions of cholinergic/prostaglandin systems participate in neuroimmunomodulation; microsomal Ptges-1 is part of cholinergic anti-inflammatory response in chronic inflammatory diseases.
Prostacyclin synthase (show PTGIS ELISA Kits) and prostaglandin E synthase-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.
Gas6 (show GAS6 ELISA Kits), through upregulation of Ptges/PGE2, contributes to cancer-induced venous thrombosis.
The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2 (show PTGS2 ELISA Kits)), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.
Prostaglandin E synthase interacts with inducible heat shock protein 70 (show HSPA1A ELISA Kits) after heat stress in bovine primary dermal fibroblast cells.
Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF (show TNF ELISA Kits)) and Fas (show FAS ELISA Kits) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of PGES and HSP90AA1 (show HSP90AA1 ELISA Kits) (heat shock 90 kD protein 1 alpha).
PGES pathway is responsible for the endometrial production of PGE (show LIPF ELISA Kits)(2) in the bovine endometrium during the estrous cycle
This study showed that COX-1 (show PTGS1 ELISA Kits) and COX-2 (show PTGS2 ELISA Kits) in genital carcinomas in the horse is poor; microsomal PGES-1 is more prominently expressed.
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.
microsomal prostaglandin E synthase-1
, prostaglandin E synthase
, MGST1-like 1
, glutathione S-transferase 1-like 1
, microsomal glutathione S-transferase 1-like 1
, microsomal prostaglandin E synthase 1
, p53-induced apoptosis protein 12
, p53-induced gene 12 protein
, tumor protein p53 inducible protein 12