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This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin.
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Rat (Rattus) PTGS1 ELISA Kit for Sandwich ELISA - ABIN457221
Uzun, Atli, Perk, Burukoglu, Ilgin: Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats. in Human & experimental toxicology 2014
This study showed that COX-1 and COX-2 (show PTGS2 ELISA Kits) in genital carcinomas in the horse is poor; microsomal PGES (show PTGES ELISA Kits)-1 is more prominently expressed.
COX-1 and COX-2 (show PTGS2 ELISA Kits) genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 (show PTGS2 ELISA Kits) gene expression at each subsequent time point, compared with baseline values.
In this study, both COX-1 and COX-2 (show PTGS2 ELISA Kits) were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2 (show PTGS2 ELISA Kits).
Immunoreactivity for COX-1 and COX-2 (show PTGS2 ELISA Kits) is high in equine corneal SCC (show CYP11A1 ELISA Kits), possibly indicating that COX plays a role in oncogenesis or progression of this tumor type at this site.
These results suggest that licochalcones inhibit collagen-induced platelet aggregation accompanied by inhibition of COX-1 (show COX1 ELISA Kits) activity.
IFNgamma upregulated microsomal prostaglandin E synthase-1 (mPGES-1 (show PTGES ELISA Kits)) alongside cyclo-oxygenase (COX-1) within macrophage populations, resulting in sustained prostaglandin (PG)E2 biosynthesis.
Data (including data from studies in knockout mice) suggest that delayed parturition in Cox-1 knockout mice is result of impaired luteolysis and cervical dilation, despite the presence of strong uterine contractions.
Data suggest that Il4 (show IL4 ELISA Kits) (usually released from helper T-cells) induces Cox1 (show COX1 ELISA Kits) in macrophages at post-transcriptional level; activation of Ampk (show PRKAA1 ELISA Kits) (catalytic subunit Prkaa1 (show PRKAA1 ELISA Kits)) by metformin blocks Il4 (show IL4 ELISA Kits)-dependent induction of Cox1 (show COX1 ELISA Kits) and blocks macrophage polarization/activation. (Il4 (show IL4 ELISA Kits) = interleukin-4 (show IL4 ELISA Kits); Cox1 (show COX1 ELISA Kits) = cyclooxygenase 1; Ampk (show PRKAA1 ELISA Kits) = AMP-activated protein kinase (show PRKAA2 ELISA Kits))
Specific inhibition of PGE2 synthesis by targeting mPGES-1 (show PTGES ELISA Kits) may weaken host defense against bacterial infections.
Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (show YWHAZ ELISA Kits), lipoxygenase and cyclooxygenase.
role of cyclooxygenase-1 and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas
Suggest the expression of COX-1 and COX-2 (show COX2 ELISA Kits) in the urothelium protects bladder damage from radiation.
COX-1 inhibitor SC-560 has a protective effect on the thromboxane A2-mediated decrease in renal function in response to endotoxin.
Expression of COX-1 is essential for the protection of liver against chemical-induced hepatotoxicity and required for hepatic homeostatic maintenance.
Data suggest that multitarget FAAH (show FAAH ELISA Kits)/Cox blockade may provide a transformative approach to inflammatory bowel disease (IBD) and other pathologies in which fatty acid amide hydrolase (show FAAH ELISA Kits)/cyclooxygenases (FAAH (show FAAH ELISA Kits), Cox-1, and Cox-2 (show COX2 ELISA Kits)) are overactive.
there was no expression of COX-1, either mRNA or protein, on any day of the estrous cycle
Extracellular histones disarrange vasoactive mediators release through a COX1 (show COX1 ELISA Kits)-COX2 (show COX2 ELISA Kits)-eNOS (show NOS3 ELISA Kits) interaction in human endothelial cells.
Results suggested that in Chinese Han patients with stroke taking aspirin for secondary prevention, PTGS1 polymorphisms may increase the risk of poor functional outcomes and this effect may be modulated by the smoking status. PTGS1 gene-smoking interaction might in part reflect the heterogeneity in the prognosis of patients treated with aspirin.
analysis of co-existing variants in both F8 and PTGS-1 genes in a three-generation pedigree of hemophilia A; the PTGS-1 variant was associated with specific functional defects in the arachidonic acid pathway and more severe hemorrhage.
Data suggest expression of PTGS1 in colon is significantly correlated with expression of PTGS2 (show PTGS2 ELISA Kits), PTGES1, PTGER2 (show PTGER2 ELISA Kits), and PTGER4; this study was conducted in individuals at high risk for colon cancer treated with Mediterranean diet versus a Healthy Eating diet for prevention of colon cancer. (PG = prostaglandin; PTGS2 (show PTGS2 ELISA Kits) = PG-endoperoxide synthase 2; PTGES1 = PGE (show LIPF ELISA Kits) synthase protein; PTGER2 (show PTGER2 ELISA Kits) = PGE (show LIPF ELISA Kits) receptor 2; PTGER4 = PGE (show LIPF ELISA Kits) receptor 4)
Panax quinquefolium saponin attenuated HUVEC apoptosis and improved the dual antiplatelet-mediated reduction of platelet adhesion to injured HUVECs and the underlying mechanisms may be associated with PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) and COX pathways.
The interactions of COX-1of rs3842787 and cox-2 (show COX2 ELISA Kits) of rs20417 were associated with aspirin resistance of stroke.
We provide the first report that pro-angiogenic genes PECAM1 (show PECAM1 ELISA Kits), PTGS1, FGD5, and MCAM (show MCAM ELISA Kits) may play a vital role in pathological dermal angiogenesis disorders of psoriasis.
a new neutrophil-activating platelet-derived lipid generated by COX-1 (show COX1 ELISA Kits) is presented that can activate or prime human neutrophils, suggesting a role in innate immunity and acute inflammation.
Seminal COX-1 (show COX1 ELISA Kits) is over-expressed in infertile oligoasthenoteratozoospermic (OAT (show OAT ELISA Kits)) men with varicocele (Vx) compared with fertile men with/without and infertile OAT (show OAT ELISA Kits) men without Vx being associated with oxidative stress, Vx grade and Vx laterality.
Brain death increases the expression of COX-1 (show COX1 ELISA Kits) and COX-2 (show PTGS2 ELISA Kits) mRNA in the renal medulla
Endometrial prostaglandin-endoperoxide synthase 1 (PTGS1) mRNA expression increased 2- to 3-fold after Day 10 of the estrous cycle and pregnancy, whereas PTGS2 (show PTGS2 ELISA Kits) mRNA expression increased 76-fold between Days 5 and 15 of the estrous cycle and pregnancy.
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.
, prostaglandin G/H synthase 1
, prostaglandin G/H synthase and cyclooxygenase
, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
, PGH synthase 1
, PHS 1
, prostaglandin H2 synthase 1
, prostaglandin-endoperoxide synthase 1
, cyclooxygenase 1
, cyclooxygenase 3
, prostaglandin endoperoxide synthase