Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) ELISA Kits

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. Additionally we are shipping PTGS1 Antibodies (203) and PTGS1 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PTGS1 19224 P22437
PTGS1 24693 Q63921
PTGS1 5742 P23219
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Top PTGS1 ELISA Kits at antibodies-online.com

Showing 10 out of 50 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.195 ng/mL 0.78-50 ng/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Rat 1.95 pg/mL 7.8-500 pg/mL Typical standard curve 96 Tests 13 to 16 Days
$1,026.67
Details
Goat 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests 13 to 16 Days
$1,026.67
Details
Mouse 46.875 pg/mL 78.125-5000 pg/mL Typical standard curve 96 Tests 12 to 14 Days
$630.00
Details
Cow
  96 Tests 2 to 3 Days
$867.90
Details
Guinea Pig 1.0 pg/mL 100-2500 pg/mL   96 Tests 15 to 18 Days
$707.14
Details
Pig 1.0 pg/mL 250-5000 pg/mL   96 Tests 15 to 18 Days
$707.14
Details
Rabbit 0.375 ng/mL 0.62 ng/mL - 40 ng/mL A typical standard curve 96 Tests 13 to 16 Days
$576.62
Details
Chicken 0.938 ng/mL 1.563-100 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Monkey 0.375 ng/mL 0.625-40 ng/mL   96 Tests 12 to 14 Days
$715.00
Details

Top referenced PTGS1 ELISA Kits

  1. Rat (Rattus) PTGS1 ELISA Kit for Sandwich ELISA - ABIN457221 : Uzun, Atli, Perk, Burukoglu, Ilgin: Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats. in Human & experimental toxicology 2014 (PubMed)

More ELISA Kits for PTGS1 Interaction Partners

Horse (Equine) Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) interaction partners

  1. This study showed that COX-1 and COX-2 in genital carcinomas in the horse is poor; microsomal PGES-1 is more prominently expressed.

  2. COX-1 and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.

  3. In this study, both COX-1 and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.

  4. Immunoreactivity for COX-1 and COX-2 is high in equine corneal SCC, possibly indicating that COX plays a role in oncogenesis or progression of this tumor type at this site.

Rabbit Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) interaction partners

  1. These results suggest that licochalcones inhibit collagen-induced platelet aggregation accompanied by inhibition of COX-1 activity.

Mouse (Murine) Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) interaction partners

  1. Expression of COX-1 and production of thromboxane A2 in platelets of STZ-induced diabetic mice were elevated.

  2. Manipulation of COXs 1 & 2 revealed isoform-specific compensatory functions and variable degrees of interchangeability for PG biosynthesis in cells/tissues

  3. the highly expressed knockin COX-2 enzyme barely makes any PGs or thromboxane in neonatal P8 or adult mice, demonstrating that prostanoid biosynthesis requires native COX-1 and cannot be rescued by the knockin COX-2. In summary, the 2 COX isoforms can preferentially compensate for some renal functions, which appears to be independent of the PG-synthetic capacity.

  4. IFNgamma upregulated microsomal prostaglandin E synthase-1 (mPGES-1) alongside cyclo-oxygenase (COX-1) within macrophage populations, resulting in sustained prostaglandin (PG)E2 biosynthesis.

  5. Data (including data from studies in knockout mice) suggest that delayed parturition in Cox-1 knockout mice is result of impaired luteolysis and cervical dilation, despite the presence of strong uterine contractions.

  6. Data suggest that Il4 (usually released from helper T-cells) induces Cox1 in macrophages at post-transcriptional level; activation of Ampk (catalytic subunit Prkaa1) by metformin blocks Il4-dependent induction of Cox1 and blocks macrophage polarization/activation. (Il4 = interleukin-4; Cox1 = cyclooxygenase 1; Ampk = AMP-activated protein kinase)

  7. Specific inhibition of PGE2 synthesis by targeting mPGES-1 may weaken host defense against bacterial infections.

  8. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2, lipoxygenase and cyclooxygenase.

  9. role of cyclooxygenase-1 and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas

  10. Suggest the expression of COX-1 and COX-2 in the urothelium protects bladder damage from radiation.

  11. COX-1 inhibitor SC-560 has a protective effect on the thromboxane A2-mediated decrease in renal function in response to endotoxin.

  12. Expression of COX-1 is essential for the protection of liver against chemical-induced hepatotoxicity and required for hepatic homeostatic maintenance.

  13. Data suggest that multitarget FAAH/Cox blockade may provide a transformative approach to inflammatory bowel disease (IBD) and other pathologies in which fatty acid amide hydrolase/cyclooxygenases (FAAH, Cox-1, and Cox-2) are overactive.

  14. In arteries from non-insulin-dependent diabetic mice, COX-1 remains a major contributor to the endothelial PGI2 synthesis that evokes vasoconstrictor activity under the pathological condition.

  15. specific inhibition of mmu-miR-100-5p significantly enhanced expression of Il6, Ptgs1/2 and Tlr4 mRNA

  16. COX1/2-derived prostanoids appear to play an important role in the TLR response, with elevated cytokine levels following COX1/2 inhibition or genetic deletion.

  17. Data suggest deletion of Cox1 delays ovarian follicle development prior to reproductive maturation of mutant mouse strain (Wv); inhibition of Cox1 (but not Cox2) may prolong ovarian follicle lifespan and delay the onset of premature ovarian failure.

  18. role of COX-1 during maturation of adipocyte

  19. The production of prostanoids found in the systemic circulation is driven overwhelmingly by COX-1 and not COX-2.

  20. Prostaglandin G/H synthase is a moonlighting protein that functions both as a peroxidase as well as a cyclooxygenase.

Cow (Bovine) Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) interaction partners

  1. there was no expression of COX-1, either mRNA or protein, on any day of the estrous cycle

Human Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) interaction partners

  1. ZBTB46 is inversely correlated with SPDEF and is increased in higher tumor grades and small-cell NE prostate cancer (SCNC) patients, which are positively associated with PTGS1. Findings suggest that the induction of ZBTB46 results in increased PTGS1 expression, which is associated with NEPC progression and linked to the dysregulation of the AR-SPDEF pathway.

  2. COX1 inhibition significantly triggered cell death.

  3. Prostaglandin D2 generation from human lung mast cells is catalysed exclusively by cyclooxygenase-1

  4. Extracellular histones disarrange vasoactive mediators release through a COX1-COX2-eNOS interaction in human endothelial cells.

  5. Results suggested that in Chinese Han patients with stroke taking aspirin for secondary prevention, PTGS1 polymorphisms may increase the risk of poor functional outcomes and this effect may be modulated by the smoking status. PTGS1 gene-smoking interaction might in part reflect the heterogeneity in the prognosis of patients treated with aspirin.

  6. analysis of co-existing variants in both F8 and PTGS-1 genes in a three-generation pedigree of hemophilia A; the PTGS-1 variant was associated with specific functional defects in the arachidonic acid pathway and more severe hemorrhage.

  7. Data suggest expression of PTGS1 in colon is significantly correlated with expression of PTGS2, PTGES1, PTGER2, and PTGER4; this study was conducted in individuals at high risk for colon cancer treated with Mediterranean diet versus a Healthy Eating diet for prevention of colon cancer. (PG = prostaglandin; PTGS2 = PG-endoperoxide synthase 2; PTGES1 = PGE synthase protein; PTGER2 = PGE receptor 2; PTGER4 = PGE receptor 4)

  8. Epithelial Cells Induce a Cyclo-Oxygenase-1-Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype

  9. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2, lipoxygenase and cyclooxygenase.

  10. Panax quinquefolium saponin attenuated HUVEC apoptosis and improved the dual antiplatelet-mediated reduction of platelet adhesion to injured HUVECs and the underlying mechanisms may be associated with PI3K/AKT and COX pathways.

  11. The interactions of COX-1of rs3842787 and cox-2 of rs20417 were associated with aspirin resistance of stroke.

  12. Results show a trend toward an association between rs1236913 SNP and worst pain scores on nonsurgical root canal therapy post-treatment day 1

  13. We provide the first report that pro-angiogenic genes PECAM1, PTGS1, FGD5, and MCAM may play a vital role in pathological dermal angiogenesis disorders of psoriasis.

  14. a new neutrophil-activating platelet-derived lipid generated by COX-1 is presented that can activate or prime human neutrophils, suggesting a role in innate immunity and acute inflammation.

  15. Seminal COX-1 is over-expressed in infertile oligoasthenoteratozoospermic (OAT) men with varicocele (Vx) compared with fertile men with/without and infertile OAT men without Vx being associated with oxidative stress, Vx grade and Vx laterality.

  16. variable turnover rate represents the most convincing determinant of the inter-individual variability in response to aspirin for primary prevention in diabetes mellitus

  17. In Indian peptic ulcer hemorrhage patients, those with Cox-1 A842G polymorphisms tended to have less gastric ulcers among those with the A842G/C50T polymorphism.

  18. single nucleotide polymorphisms show a protective effect under a dominant model of diisocyanate-induced asthma

  19. inverse allosteric regulation likely underlies the ability of PGHS-2 to operate at low AA concentrations, when PGHS-1 is effectively latent.

  20. PON1, P2Y12 and COX1 polymorphisms were associated with poorer vascular outcomes in patients with extracranial or intracranial stents.

Pig (Porcine) Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) interaction partners

  1. Brain death increases the expression of COX-1 and COX-2 mRNA in the renal medulla

  2. Endometrial prostaglandin-endoperoxide synthase 1 (PTGS1) mRNA expression increased 2- to 3-fold after Day 10 of the estrous cycle and pregnancy, whereas PTGS2 mRNA expression increased 76-fold between Days 5 and 15 of the estrous cycle and pregnancy.

PTGS1 Antigen Profile

Antigen Summary

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PTGS1

  • prostaglandin-endoperoxide synthase 1 (PTGS1) antibody
  • cyclooxygenase-1 (cox-1) antibody
  • prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1) antibody
  • prostaglandin-endoperoxide synthase 1 (Ptgs1) antibody
  • prostaglandin-endoperoxide synthase 1 (ptgs1) antibody
  • prostaglandin-endoperoxide synthase 1 S homeolog (ptgs1.S) antibody
  • Cox-1 antibody
  • COX-3 antibody
  • cox1 antibody
  • COX3 antibody
  • PCOX1 antibody
  • PES-1 antibody
  • PGG/HS antibody
  • PGHS-1 antibody
  • PGHS1 antibody
  • PHS 1 antibody
  • PHS1 antibody
  • PTGHS antibody
  • Ptgs1 antibody
  • zCOX-1 antibody

Protein level used designations for PTGS1

cyclooxygenase-1 , prostaglandin G/H synthase 1 , prostaglandin G/H synthase and cyclooxygenase , prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) , PGH synthase 1 , PGHS-1 , PHS 1 , prostaglandin H2 synthase 1 , prostaglandin-endoperoxide synthase 1 , cyclooxygenase 1 , COX-1 , cyclooxygenase 3 , Cox-1 , Cox-1b , prostaglandin endoperoxide synthase , cyclooxygenase

GENE ID SPECIES
100034087 Equus caballus
100136038 Oncorhynchus mykiss
427752 Gallus gallus
464713 Pan troglodytes
698213 Macaca mulatta
100585600 Nomascus leucogenys
100009407 Oryctolagus cuniculus
19224 Mus musculus
24693 Rattus norvegicus
246226 Danio rerio
282022 Bos taurus
5742 Homo sapiens
443551 Ovis aries
403544 Canis lupus familiaris
397541 Sus scrofa
100037245 Xenopus laevis
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