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PSCA encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein.
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Study shows that PSCA gene is a target of 8q24 locus in Invasive micropapillary carcinoma (IMPC) of the breast, and the PSCA gene amplification results in PSCA protein overexpression. These results demonstrate an independently worse prognosis for PSCA overexpression in IMPC, and suggest that the differential expression of PSCA is associated with cell adhesion molecules in breast cancer.
the PSCA rs2294008 polymorphism may serve as a biomarker of cervical cancer, particularly of early-stage cervical cancer
The expression of Ki-67 (show MKI67 Proteins), PSCA, and Cox-2 biomarkers along with other clinicopathologic factors were prognostic factors for biochemical recurrence in patients with clinically localized prostate cancer following radical prostatectomy
Among Chinese Han women, the PSCA rs2294008, rs2978974, and rs2976392 minor alleles are associated with increased breast cancer risk especially in progesterone receptor (show PGR Proteins) positive breast cancer patients, with breast cancer risk in postmenopausal women, and with high lymph node metastasis risk, respectively.
PSCA is a novel cell cycle regulator with a key role in prostate cancer cell proliferation.
PSCA regulates IL-6 (show IL6 Proteins) expression through p38 (show CRK Proteins)/NF-kappaB (show NFKB1 Proteins) signaling in Prostate cancer.
the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for gastric cancer in this study population.
analysis of PSCA level in the peripheral blood of PC patients who underwent radical prostatectomy shows it is related to a GADPH (show GAPDH Proteins) reference level (PSCA/GAPDH (show GAPDH Proteins) ratio)
our data provide a novel molecular mechanism for the tumor suppressor role of PSCA
suggest that PSCA is a useful tissue marker for predicting biochemical recurrence in patients with high risk PC receiving NHT and radical prostatectomy
Increase in prostate stem cell antigen expression in prostatic hyperplasia induced by testosterone and 17beta-estradiol in C57BL mice
This transgenic system helps define the range of cellular changes associated with altered expression of PSCA, shows that transcriptional control is a major component regulating PSCA levels.
Sca-1-enriched prostate-regenerating cells possess multiple stem/progenitor cell properties
PSCA may play a role in limiting prostate tumor progression in certain contexts, and deletion of PSCA may promote tumor migration and metastasis.
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals\; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants.
prostate stem cell antigen