anti-Protease, serine, 3 (PRSS3) Antibodies

PRSS3 encodes a trypsinogen, which is a member of the trypsin family of serine proteases. Additionally we are shipping PRSS3 Proteins (11) and PRSS3 Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PRSS3 5646 P35030
PRSS3 286911 P08426
PRSS3 22073  
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Top anti-PRSS3 Antibodies at antibodies-online.com

Showing 10 out of 78 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PRSS3 Antibody Titration: 0.2-1 ug/mlPositive Control: Human Muscle WB Suggested Anti-PRSS3  Antibody Titration: 0.2-1 µg/mL  Positive Control: Human Muscle 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of Trypsin 3 expression in MDAMB231 (A), HL60 (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram) using Trypsin-3 / PRSS3  Antibody (N-term), followed by FITC-conjugated goat-anti-rabbit secondary antibodies. Immunohistochemistry analysis in human pancreas tissue (Formalin-fixed, Paraffin-embedded) using Trypsin-3 / PRSS3  Antibody  (N-term), followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PRSS3 antibody for IHC; Clinical relevance has not been evaluated. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of HL-60 cells using RSS3 Antibody (Center) Cat.-No AP53469PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin fixed and paraffin embedded human pancreas tissue reacted with RSS3 Antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of Trypsin-3 using Jurkat whole cell lysates 100 μL 11 to 12 Days
$390.77
Details
Chicken Rabbit Un-conjugated IHC, IHC (p), WB Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested. 100 μL 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western Blot at 1:1000 dilution Lane 1: MDA-MB-231 whole cell lysate Lane 2: human pancreas lysate Lysates/proteins at 20 ug per lane. PRSS3 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Western blot (WB) analysis of Trypsin-3 antibody in extracts from A549 cells 0.1 mg 6 to 8 Days
$434.50
Details
Human Rabbit HRP ELISA, IHC, IHC (p), WB Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested. 100 μg 11 to 14 Days
$581.17
Details

More Antibodies against PRSS3 Interaction Partners

Human Protease, serine, 3 (PRSS3) interaction partners

  1. PRSS3 appears to act as an oncogene of gastric cancer. High PRSS3 expression portends postoperative metastasis.

  2. EK and EK-X2 trigger Influenza A Virus HA processing by activating the PRSS3 trypsinogen.

  3. PRSS3 is downregulated by intragenic hypermethylation in HCC. * Epigenetic silencing of PRSS3 facilitates growth, migration, and invasion of HCC. * PRSS3 intragenic methylation has implication in diagnosis of HCC.

  4. PRSS3 acts as an oncogene in invasive ductal carcinoma of the breast development and progression

  5. Study developed a new high resolution crystal structure of mesotrypsin complexed with diminazene through a structure-based molecular docking screen that could help facilitate derivatization efforts, addressing current pan-inhibition of human trypsins through rigidification of diminazene to select for a conformation that maximizes interactions with the non-conserved Arg-193 residue.

  6. Data show that silencing tumor-endothelial cells (EC) for trypsinogen 4 accumulated tissue factor pathway inhibitor-2 (TFPI-2) in the matrix.

  7. These findings suggest that inhibitor cleavage represents a functional adaptation of mesotrypsin that may have evolved in response to positive selection pressure.

  8. High PRSS3 expression in EOC tissues was significantly associated with advanced FIGO stage and lymph node metastasis.

  9. Data suggest that mesotrypsin cleavage of Kunitz domains may contribute to cancer progression.

  10. Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.

  11. extra-pancreatic trypsinogen 3 is produced by esophageal adenocarcinoma cells and activates PAR-2 in an autocrine manner.

  12. IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3

  13. Report PRSS3/mesotrypsin upregulation in breast cancer cells and identify CD109 as the functional proteolytic target of mesotrypsin.

  14. PRSS3 plays an important role in the progression, metastasis and prognosis of human pancreatic cancer.

  15. Investigation did not reveal an association between PRSS3 variants and chronic pancreatitis.

  16. Because mesotrypsin is resistant to naturally occurring trypsin inhibitors, confined expression of the isoforms of mesotrypsinogens and enteropeptidase may indicate that mesotrypsin is involved in keratinocyte terminal differentiation

  17. Processing by mesotrypsin may ablate the protease inhibitory function of APP/protease nexin 2 in vivo and may also modulate other activities of APP/protease nexin 2 that involve the Kunitz domain.

  18. X-ray structure in complex with the inhibitor benzamidine at 1.7 A resolution; crystal structure reveals basis for inhibitor resistance

  19. biological function of human mesotrypsin is digestive degradation of trypsin inhibitors

  20. The results classify E32del mesotrypsinogen as a frequent polymorphic variant, which is not associated with chronic alcoholic pancreatitis

Mouse (Murine) Protease, serine, 3 (PRSS3) interaction partners

  1. Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.

  2. Intra-acinar activation of trypsinogen is sufficient to initiate acute pancreatitis.

  3. These results underscore the importance of trypsinogen PRSS1 mutations as pathogenic mediators of hereditary pancreatitis and indicate that persistent pancreatic injury might be causally linked to chronic pancreatitis.

  4. the initiation of acute pancreatitis depends on endocytic vacuole formation and trypsinogen activation in pancreatic acinar cells

PRSS3 Antigen Profile

Protein Summary

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with PRSS3

  • protease, serine 3 (PRSS3) antibody
  • trypsin-3 (CpipJ_CPIJ016105) antibody
  • protease, serine, 3 (Prss3) antibody
  • protease, serine 3 (Prss3) antibody
  • trypsin III (trp-iii) antibody
  • protease, serine 3 L homeolog (prss3.L) antibody
  • protease, serine, 3 (PRSS3) antibody
  • MTG antibody
  • prss3 antibody
  • PRSS4 antibody
  • T9 antibody
  • Tb antibody
  • Try3 antibody
  • TRY4 antibody

Protein level used designations for PRSS3

brain trypsinogen , mesotrypsin , mesotrypsinogen , pancreatic trypsinogen III , protease, serine, 4 (trypsin 4, brain) , trypsin III , trypsin IV , trypsin-3 , trypsinogen 4 , trypsinogen 5 , trypsinogen IV , cationic trypsin III , cationic trypsin-3 , cationic trypsinogen , pretrypsinogen III , trypsin 3 , trypsinogen 15 , protease, serine 3 L homeolog , protease, serine, 3

GENE ID SPECIES
5646 Homo sapiens
6049341 Culex quinquefasciatus
286911 Rattus norvegicus
22073 Mus musculus
100137024 Salmo salar
447093 Xenopus laevis
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