Proteasome Maturation Protein Proteins (POMP)

The protein encoded by POMP is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation.

list all proteins Gene Name GeneID UniProt
Human POMP POMP 51371 Q9Y244
Mouse POMP POMP 66537 Q9CQT5
Rat POMP POMP 288455  
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Top POMP Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Yeast Orang-Utan His tag   1 mg Log in to see 60 to 71 Days
$2,302.67
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,302.67
Details
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$611.00
Details

More Proteins for Proteasome Maturation Protein (POMP) Interaction Partners

Human Proteasome Maturation Protein (POMP) interaction partners

  1. POMP is overexpressed and participates in the increase of proteasome assembly and activity in psoriatic skin.

  2. MCM3AP (show MCM3AP Proteins) and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child

  3. studies validate a role for the NRF2 (show GABPA Proteins)/POMP axis in bortezomib resistance and identify NRF2 (show GABPA Proteins) and POMP as potentially attractive targets for chemosensitization to this proteasome inhibitor

  4. microRNA-101 (miR (show MLXIP Proteins)-101) targets the proteasome maturation protein POMP, leading to impaired proteasome assembly and activity, and resulting in accumulation of p53 (show TP53 Proteins) and cyclin-dependent kinase (show CDK1 Proteins) inhibitors, cell cycle arrest, and apoptosis.

  5. Single-nucleotide polymorphisms in POMP gene is associated with breast cancer risk after menopausal hormone replacement therapy.

  6. KLICK is caused by reduced levels of POMP, leading to proteasome insufficiency in differentiating keratinocytes

  7. A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis.

  8. POMP/proteassemblin/hUmp1 may be tetramerised and is localized to the cytoplasm and the nucleus

  9. Data show that POMP facilitates the main steps in 20S core complex formation at the ER to coordinate the assembly process and to provide cells with freshly formed proteasomes at their site of function.

POMP Protein Profile

Protein Summary

The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder.

Gene names and symbols associated with POMP

  • proteasome maturation protein S homeolog (pomp.S)
  • proteasome maturation protein (POMP)
  • proteasome maturation protein (pomp)
  • proteasome maturation protein (Pomp)
  • 2510048O06Rik protein
  • C13orf12 protein
  • fa13f09 protein
  • MGC81104 protein
  • MGC89819 protein
  • PNAS-110 protein
  • RGD1305831 protein
  • Ump1 protein
  • wu:fa13f09 protein
  • zgc:92775 protein

Protein level used designations for POMP

proteasome maturation protein , 2510048O06Rik , hUMP1 , proteassemblin , protein UMP1 homolog , voltage-gated K channel beta subunit 4.1 , voltage-gated potassium channel beta subunit 4.1 , mUMP1

GENE ID SPECIES
414726 Xenopus laevis
418925 Gallus gallus
448670 Xenopus (Silurana) tropicalis
445030 Danio rerio
100168236 Acyrthosiphon pisum
100528728 Ictalurus punctatus
51371 Homo sapiens
66537 Mus musculus
288455 Rattus norvegicus
510314 Bos taurus
100172839 Pongo abelii
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