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The protein encoded by POMP is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation.
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POMP is overexpressed and participates in the increase of proteasome assembly and activity in psoriatic skin.
MCM3AP (show MCM3AP Proteins) and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child
studies validate a role for the NRF2 (show GABPA Proteins)/POMP axis in bortezomib resistance and identify NRF2 (show GABPA Proteins) and POMP as potentially attractive targets for chemosensitization to this proteasome inhibitor
microRNA-101 (miR (show MLXIP Proteins)-101) targets the proteasome maturation protein POMP, leading to impaired proteasome assembly and activity, and resulting in accumulation of p53 (show TP53 Proteins) and cyclin-dependent kinase (show CDK1 Proteins) inhibitors, cell cycle arrest, and apoptosis.
Single-nucleotide polymorphisms in POMP gene is associated with breast cancer risk after menopausal hormone replacement therapy.
KLICK is caused by reduced levels of POMP, leading to proteasome insufficiency in differentiating keratinocytes
A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis.
POMP/proteassemblin/hUmp1 may be tetramerised and is localized to the cytoplasm and the nucleus
Data show that POMP facilitates the main steps in 20S core complex formation at the ER to coordinate the assembly process and to provide cells with freshly formed proteasomes at their site of function.
The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder.
proteasome maturation protein
, protein UMP1 homolog
, voltage-gated K channel beta subunit 4.1
, voltage-gated potassium channel beta subunit 4.1