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Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. Additionally we are shipping Proteasome-Associated Protein ECM29 Homolog Antibodies (14) and and many more products for this protein.
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Data suggest that the adapter protein ECM29 is the main proteasome-interacting protein responsible for oxidative stress-induced proteasome disassembly/remodeling; ECM29 appears to intrude on interaction between the 20S core particle and 19S regulatory particle in 26S proteasome, disrupting proteasome structure in response to oxidative stress.
Ecm29 is involved in the dissociation process of 26S proteasome, providing clue to analyse the mechanism of proteasomal degradation under various stress condition.
The absence of Ecm29 enhanced TLR3 signaling, which was characterized by the increased abundance of the adaptor protein and E3 ubiquitin ligase tumor necrosis factor receptor-associated factor 3
Ecm29 serves as an adaptor for coupling 26 S proteasomes to specific cellular compartments.
Ecm29 protein serves to couple the 26 S proteasome to secretory compartments engaged in quality control and to other sites of enhanced proteolysis
Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis (By similarity).
proteasome-associated protein ECM29 homolog
, Proteasome-associated protein ECM29 homolog
, ECM29 homolog, proteasome accessory protein
, homolog of yeast Ecm29