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Protein Kinase, CGMP-Dependent, Type I (PRKG1) ELISA Kits

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II).

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat PRKG1 PRKG1 54286  
Anti-Human PRKG1 PRKG1 5592 Q13976
Anti-Mouse PRKG1 PRKG1 19091 P0C605
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Top Protein Kinase, CGMP-Dependent, Type I ELISA Kits at antibodies-online.com

Showing 9 out of 23 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.063 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$736.84
Details
Mouse 0.059 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$757.89
Details
Pig 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Rabbit 37.5 pg/mL 62.5-4000 pg/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Guinea Pig 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Chicken 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Monkey 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Human 18.75 pg/mL 31.25 pg/mL - 2000 pg/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Cow
  96 Tests Log in to see 15 to 18 Days
$1,029.60
Details

More ELISA Kits for Protein Kinase, CGMP-Dependent, Type I Interaction Partners

Human Protein Kinase, CGMP-Dependent, Type I (PRKG1) interaction partners

  1. PRKG1, known to induce apoptosis when activated, is increased in all patient derived glioblastoma spheres

  2. redox-mediated guidance required PKG1 and consequently, its deficiency in vivo resulted in defective repair and enhanced neuropathic pain after nerve injury. PKG1-dependent repair functions will outweigh its signaling functions in spinal nociceptive LTP (show SCP2 ELISA Kits), so that inhibition of PKG1 is no option for neuropathic pain.

  3. Oxidant signaling underlies PKGIalpha modulation of Ca2+ sparks and BKCa in myogenically active arterioles

  4. These affinity and activation measurements show that beta-phenyl-1,N2-ethenoguanosine 3',5'-monophosphate (PET-cGMP) is most selective for PKG I, whereas 8-(4-chlorophenylthio)guanosine-3'-5'-cyclic monophosphate (8-pCPT-cGMP) is most selective for PKG II.

  5. Hence, SO2 exerted its vasodilatory effects at least partly by promoting disulfide-dependent dimerization of sGC and PKG, resulting in an activated sGC/cGMP/PKG pathway in blood vessels. These findings revealed a new mode of action and mechanisms by which SO2 regulated the vascular tone.

  6. these data indicate PKG as an intermediary in EGFR (show EGFR ELISA Kits)-mediated cell death, likely via apoptotic pathway.

  7. The heterozygous c.530G>A:p.Arg177Gln PRKG1 variant was associated with early-onset thoracic aortic aneurysm and dissection in a Spanish family.

  8. cAMP is a partial agonist for PKG, and we elucidate the mechanism for cAMP partial agonism through the comparative NMR analysis of the apo (show C9orf3 ELISA Kits), cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain B.

  9. Protein kinase G has a role in regulating production of H2S, which governs oxygen sensing

  10. The C42-C42' disulfide bond dramatically stabilizes PRKG1.

Cow (Bovine) Protein Kinase, CGMP-Dependent, Type I (PRKG1) interaction partners

  1. NADPH regulation of PKG1-alpha dimerization may contribute to vascular responses to hypoxia that are associated with changes in NADPH redox.

  2. The data suggest that PKG-I expression is subjected to post-transcriptional regulation in VSMC through the 3'UTR (show UTS2R ELISA Kits) of its mRNA.

  3. Report roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia.

  4. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication

  5. purified cGMP kinase signaling complex contained alpha-actin (show ACTA2 ELISA Kits), calponin H1, and phospholamban (show PLN ELISA Kits)

  6. studies suggest that cross-activation of PKA in response to iNOS expression by inflammatory mediators downregulates cGMP-dependent protein kinase expression in bovine aortic vascular smooth muscle cells

  7. Demonstrate a novel PKG-dependent pathway by which the Rac1/Pak1 (show PAK1 ELISA Kits) pathway is activated.

  8. cGMP-dependent protein kinase expression is regulated by soluble guanylyl cyclase in vascular smooth muscle cells

  9. cGMP-dependent protein kinase (show CDK7 ELISA Kits) Ibeta binds to TFII-I and IRAG (show MRVI1 ELISA Kits) through a common interaction motif

  10. cGMP binding destabilizes the N-terminus of cGMP-dependent protein kinase I alpha isozyme at the hinge region, centered around residue 77, while the C-terminus is protected from degradation.

Mouse (Murine) Protein Kinase, CGMP-Dependent, Type I (PRKG1) interaction partners

  1. Despite robust evidence for PKG Ialpha oxidation during NOS (show NOS ELISA Kits) uncoupling in cell models, it is unlikely that PKG Ialpha oxidation occurs to a significant extent in vivo during diet-induced obesity and so is unlikely to mediate the associated cardiovascular dysfunction.

  2. analysis of the role of binding interface with protein kinase G-Ialpha leucine zipper in vascular function

  3. Brown adipose tissue, via Nox4-derived hydrogen peroxide, induces cyclic GMP-dependent protein kinase G type-1alpha activation, resulting in reduced vascular contractility.

  4. disulfide formation at Cys (show DNAJC5 ELISA Kits)(43) does not directly activate PKGIalpha, and the C43S-mutant PKGIalpha has a higher Ka for cGMP. Results highlight that mutant enzymes should be carefully biochemically characterized before making in vivo inferences.

  5. PKG Ialpha disulfide formation triggers cardiac injury, and this initiation of maladaptive signaling can be blocked by pharmacological therapies that elevate cGMP, which binds kinase to limit its oxidation.

  6. Cyclic GMP kinase (show GUK1 ELISA Kits) deletion causes iron deficiency anemia, duodenal ulcers, and bleeding in the knockout mice.

  7. Protein kinase G has a role in regulating production of H2S, which governs oxygen sensing

  8. cGMP/protein kinase G signaling suppresses Itpr1 phosphorylation and promotes endoplasmic reticulum stress in photoreceptors of Cnga3-deficient mice.

  9. Data show that cGMP-dependent kinase (cGK-Ialpha) knockdown partially rescued TNF-alpha (show TNF ELISA Kits)-induced decrease in 42-kDa cGMP-dependent protein kinase-anchoring protein (GKAP42 (show GKAP1 ELISA Kits)) and impairment of insulin (show INS ELISA Kits) signals.

  10. miR (show MLXIP ELISA Kits)-20a expression is up-regulated in response to hypoxia in both mouse and human pulmonary arterial smooth muscle cells

Rabbit Protein Kinase, CGMP-Dependent, Type I (PRKG1) interaction partners

  1. The novel cGMP/PKG/ROS (show ROS1 ELISA Kits)/calmodulin/CaMKII (show CAMK2G ELISA Kits) signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury.

Protein Kinase, CGMP-Dependent, Type I (PRKG1) Antigen Profile

Antigen Summary

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.

Gene names and symbols associated with PRKG1

  • protein kinase, cGMP-dependent, type Ia (prkg1a) antibody
  • protein kinase, cGMP-dependent, type I (PRKG1) antibody
  • protein kinase, cGMP-dependent, type I (prkg1) antibody
  • protein kinase, cGMP-dependent, type 1 (Prkg1) antibody
  • protein kinase, cGMP-dependent, type I (Prkg1) antibody
  • 1 antibody
  • AW125416 antibody
  • cGK antibody
  • cGK 1 antibody
  • cGK1 antibody
  • CGKI antibody
  • cGKI-alpha antibody
  • cGKI-beta antibody
  • Gm19690 antibody
  • PKG antibody
  • Pkgi antibody
  • prkg1 antibody
  • Prkg1b antibody
  • Prkg1beta antibody
  • Prkgr1b antibody
  • zgc:63955 antibody

Protein level used designations for PRKG1

cGMP-dependent protein kinase 1 , protein kinase, cGMP-dependent, type I , cGMP-dependent protein kinase 1, beta isozyme , cGMP-dependent protein kinase I alpha , cGK I alpha , cGMP-dependent protein kinase 1-like , cGMP dependent protein kinase type 1 , protein kinase, cGMP-dependent, regulatory, type I, beta , CGK 1 alpha , cGK 1 beta , cGK1 , cGKI-alpha , cGMP-dependent protein kinase 1, alpha isozyme , cGMP-dependent protein kinase I , cGK 1 , PKG1 alpha , cGMP-dependent protein kinase type 1 alpha , cGMP-dependent protein kinase type I beta

GENE ID SPECIES
394005 Danio rerio
744467 Pan troglodytes
100049290 Oryzias latipes
100388016 Callithrix jacchus
54286 Rattus norvegicus
5592 Homo sapiens
282004 Bos taurus
19091 Mus musculus
100008694 Oryctolagus cuniculus
733640 Sus scrofa
423682 Gallus gallus
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