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may regulate renin release and renal ion transport. Additionally we are shipping Protein Kinase, CGMP-Dependent, Type II Kits (10) and and many more products for this protein.
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Human Polyclonal PRKG2 Primary Antibody for IHC (p), WB - ABIN392537
Vaandrager, Hogema, Edixhoven, van den Burg, Bot, Klatt, Ruth, Hofmann, Van Damme, Vandekerckhove, de Jonge: Autophosphorylation of cGMP-dependent protein kinase type II. in The Journal of biological chemistry 2003
Show all 8 Pubmed References
This study indicates that loss of PRKG2 function results in differential expression of P53 (show TP53 Antibodies) regulated genes as well as additional pathways consistent with increased proliferation and apoptosis in the growth plate due to achondroplastic dwarfism.
PRKG2 R678X as a causative mutation for dwarfism cattle was presented.
L-Arginine (show GATM Antibodies) is a potential alternative to PKG (show PRKG1 Antibodies) II activation.
Comparative analysis of the backbone hydrogen/deuterium exchange patterns in PKG (show PRKG1 Antibodies) II:8-pCPT-cGMP and previously reported PKG (show PRKG1 Antibodies) Ibeta:cGMP XN structures suggests that the ability of these agonists to activate PKG (show PRKG1 Antibodies) is related to how effectively they quench dynamics of the cyclic nucleotide binding pocket and the surrounding regions.
the results indicated that PKG II could block c-Met activation via phosphorylating Ser985
These affinity and activation measurements show that beta-phenyl-1,N2-ethenoguanosine 3',5'-monophosphate (PET-cGMP) is most selective for PKG (show PRKG1 Antibodies) I, whereas 8-(4-chlorophenylthio)guanosine-3'-5'-cyclic monophosphate (8-pCPT-cGMP) is most selective for PKG (show PRKG1 Antibodies) II.
PKG (show PRKG1 Antibodies) II inhibits EGFinduced activation of HER2 (show ERBB2 Antibodies) through binding with and causing threonine 686 phosphorylation of this oncogenic protein.
The C-terminal cyclic nucleotide binding (CNB (show PPP3R1 Antibodies)-B) domain of cGMP-dependent protein kinase II binds cGMP with higher affinity and selectivity when compared with its N-terminal CNB (CNB (show PPP3R1 Antibodies)-A) domain.
Han Chinese patients with rs10033237 polymorphism of cGKII/PRKG2 gene are more likely to suffer from gout.
Our replication study suggests that cGKII is not involved in gout susceptibility.
we determined a crystal structure of the PKG (show PRKG1 Antibodies) II LZ-Rab11b (show RAB11B Antibodies) complex. The PKG (show PRKG1 Antibodies) II LZ domain presents a mostly nonpolar surface onto which Rab11b (show RAB11B Antibodies) docks, through van (show TNIP1 Antibodies) der (show GDF3 Antibodies) Waals interactions
PKGII inhibits RhoA (show RHOA Antibodies) activity by binding to this small GTPase (show RACGAP1 Antibodies) and causing phosphorylation at its Ser188 site.
Study shows that there are brain region-specific effects of cGMP-dependent protein kinase II knock-out on AMPA (show GRIA3 Antibodies) receptor trafficking that affects animal behavior. Study shows that GluA1 (show GRIA1 Antibodies) phosphorylation levels differ in various brain regions, and specific behaviors are altered according to region-specific changes in GluA1 (show GRIA1 Antibodies) phosphorylation.
cGKII may play a role in the integration of information that conveys both anxiety-provoking stimuli as well as the spatial and environmental cues that facilitate functional memory processes and appropriate behavioral response.
urine volume was decreased significantly in cGKII-KO subjected to volume load.
Cyclic GMP kinase (show GUK1 Antibodies) II (cGKII) inhibits NHE3 (show SLC9A3 Antibodies) by altering its trafficking and phosphorylating NHE3 (show SLC9A3 Antibodies) at three required sites
Increased PKG2 activity alters homeostasis by suppressing proliferation and apoptosis while promoting differentiation. The PKG2-dependent mechanism was shown to involve increased DUSP10 (show DUSP10 Antibodies) and subsequent inhibition of JNK (show MAPK8 Antibodies) activity.
cGKII KO mice are significantly deficient in spatial learning while exhibiting facilitated motor coordination. Data suggest that the role of cGKII may be more robust in particular regions.
cGKII and HCN2 (show HCN2 Antibodies) interact and colocalize with each other
The homeobox (show PRRX1 Antibodies) gene Nkx family is critical for the transcriptional regulation of cGK-II during chondrogenesis.
Inhibition of cGMP-dependent protein kinase II by its own splice isoform
study provides in vivo and in vitro genetic evidence that cGKII plays a critical role in C-type natriuretic peptide-mediated endochondral ossification
may regulate renin release and renal ion transport
protein kinase, cGMP-dependent, type II
, cGMP-dependant type II protein kinase
, cGMP-dependent protein kinase 2
, cGMP-dependent protein kinase 2-like
, cGK 2
, cGMP-dependent protein kinase II
, CGK 2
, cGMP dependent protein kinase type II
, protein kinase cGMP- dependent type 2
, protein kinase, cGMP- dependent, type 2
, protein kinase, cGMP- dependent, type II
, type II cGMP-dependent protein kinase