anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) Antibodies

may regulate renin release and renal ion transport. Additionally we are shipping Protein Kinase, CGMP-Dependent, Type II Kits (10) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PRKG2 5593 Q13237
PRKG2 25523 Q64595
PRKG2 19092  
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Top anti-Protein Kinase, CGMP-Dependent, Type II Antibodies at antibodies-online.com

Showing 10 out of 94 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Dog Rabbit Un-conjugated WB Western blot analysis of cGK 2 expression in HeLa (A), Hs67 (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6271535 at 1/200 staining Human pancreas tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6271535 at 1/200 staining Mouse heart tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from 293 cells, treated with anisomycin 25ug/ml 30', using PKG2 (Ab-126) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc cells, using CGK 2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of specific cells using cGKII Polyclonal Antibody. 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of 293T cells using cGKII Polyclonal Antibody. 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HUVEC cells, using CGK 2 antibody.The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB Western blot (WB) analysis of cGKii antibody  in extracts from hela cells. 0.1 mg 6 to 8 Days
$434.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of cGKII using cGKII Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PRKG2 gene (Lane 2). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma. 400 μL 2 to 3 Days
$515.63
Details

Top referenced anti-Protein Kinase, CGMP-Dependent, Type II Antibodies

  1. Human Polyclonal PRKG2 Primary Antibody for IHC (p), ELISA - ABIN544151 : Orstavik, Solberg, Taskén, Nordahl, Altherr, Hansson, Jahnsen, Sandberg: Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase. in Biochemical and biophysical research communications 1996 (PubMed)
    Show all 3 Pubmed References

More Antibodies against Protein Kinase, CGMP-Dependent, Type II Interaction Partners

Cow (Bovine) Protein Kinase, CGMP-Dependent, Type II (PRKG2) interaction partners

  1. This study indicates that loss of PRKG2 function results in differential expression of P53 regulated genes as well as additional pathways consistent with increased proliferation and apoptosis in the growth plate due to achondroplastic dwarfism.

  2. PRKG2 R678X as a causative mutation for dwarfism cattle was presented.

Human Protein Kinase, CGMP-Dependent, Type II (PRKG2) interaction partners

  1. L-Arginine is a potential alternative to PKG II activation.

  2. Comparative analysis of the backbone hydrogen/deuterium exchange patterns in PKG II:8-pCPT-cGMP and previously reported PKG Ibeta:cGMP XN structures suggests that the ability of these agonists to activate PKG is related to how effectively they quench dynamics of the cyclic nucleotide binding pocket and the surrounding regions.

  3. the results indicated that PKG II could block c-Met activation via phosphorylating Ser985

  4. These affinity and activation measurements show that beta-phenyl-1,N2-ethenoguanosine 3',5'-monophosphate (PET-cGMP) is most selective for PKG I, whereas 8-(4-chlorophenylthio)guanosine-3'-5'-cyclic monophosphate (8-pCPT-cGMP) is most selective for PKG II.

  5. PKG II inhibits EGFinduced activation of HER2 through binding with and causing threonine 686 phosphorylation of this oncogenic protein.

  6. The C-terminal cyclic nucleotide binding (CNB-B) domain of cGMP-dependent protein kinase II binds cGMP with higher affinity and selectivity when compared with its N-terminal CNB (CNB-A) domain.

  7. Han Chinese patients with rs10033237 polymorphism of cGKII/PRKG2 gene are more likely to suffer from gout.

  8. Our replication study suggests that cGKII is not involved in gout susceptibility.

  9. we determined a crystal structure of the PKG II LZ-Rab11b complex. The PKG II LZ domain presents a mostly nonpolar surface onto which Rab11b docks, through van der Waals interactions

  10. PKGII inhibits RhoA activity by binding to this small GTPase and causing phosphorylation at its Ser188 site.

  11. PKG II also inhibits the activation of the EGFR caused by diverse ligands of the receptor.

  12. These data suggest that increased PKG II activity attenuates bFGFinduced proliferation and migration by inhibiting the MAPK/ERK signaling pathway, whereas PKG I does not

  13. type II cGMPdependent protein kinase prevented the EGF-induced phosphorylation/activation of ERK and JNK, but not the phosphorylation of p38MAPK induced by EGF.

  14. Downregulation of PKG2 was associated with malignant and benign breast tumors.

  15. The work presented here demonstrates a novel antiproliferative and prodifferentiation role for PKG2 in the colon.

  16. The results suggest that PKGII inhibits EGF-induced MAPK/JNK-mediated signal transduction and further confirmed that PKGII can block the activation of EGFR.

  17. PKG II inhibits the proliferation of gastric cancer cells through blocking EGF-triggered MAPK signal transduction.

  18. As an addition to PRKG2 and RASGEFIB genes, we propose to include BMP3 gene as the principal determinant of the observed common phenotype.

  19. Inhibition of cGMP-dependent protein kinase II by its own splice isoform

  20. results show that the fast phase of autophosphorylation of cGMP dependent protein kinase II has a small effect on its activity, whereas the secondary phase involving Ser126 phosphorylation may generate an active form

Mouse (Murine) Protein Kinase, CGMP-Dependent, Type II (PRKG2) interaction partners

  1. PKG2 is a key regulator of osteoblast proliferation and post-natal bone formation.

  2. Study shows that there are brain region-specific effects of cGMP-dependent protein kinase II knock-out on AMPA receptor trafficking that affects animal behavior. Study shows that GluA1 phosphorylation levels differ in various brain regions, and specific behaviors are altered according to region-specific changes in GluA1 phosphorylation.

  3. cGKII may play a role in the integration of information that conveys both anxiety-provoking stimuli as well as the spatial and environmental cues that facilitate functional memory processes and appropriate behavioral response.

  4. urine volume was decreased significantly in cGKII-KO subjected to volume load.

  5. Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites

  6. Increased PKG2 activity alters homeostasis by suppressing proliferation and apoptosis while promoting differentiation. The PKG2-dependent mechanism was shown to involve increased DUSP10 and subsequent inhibition of JNK activity.

  7. cGKII KO mice are significantly deficient in spatial learning while exhibiting facilitated motor coordination. Data suggest that the role of cGKII may be more robust in particular regions.

  8. The work presented here demonstrates a novel antiproliferative and prodifferentiation role for PKG2 in the colon.

  9. cGKII and HCN2 interact and colocalize with each other

  10. The homeobox gene Nkx family is critical for the transcriptional regulation of cGK-II during chondrogenesis.

  11. Inhibition of cGMP-dependent protein kinase II by its own splice isoform

  12. study provides in vivo and in vitro genetic evidence that cGKII plays a critical role in C-type natriuretic peptide-mediated endochondral ossification

  13. results show that the fast phase of autophosphorylation of cGMP dependent protein kinase II has a small effect on its activity, whereas the secondary phase involving Ser126 phosphorylation may generate an active form

  14. In terms of acute responses to ethanol, cGKII-deficient mice are hyposensitive to hypnotic doses of ethanol as measured by the loss of righting reflex. In a two-bottle free choice test, cGKII-/- mice showed elevated alcohol consumption.

  15. cGK II is induced in granulosa cells of preovulatory follicles by LH- and PR-dependent mechanisms.

  16. Activation of cGKII by cGMP increases the surface expression of AMPARs at extrasynaptic sites. Inhibition of cGKII activity blocks the surface increase of GluR1 during chemLTP and reduces LTP in the hippocampal slice.

  17. These data indicate that Rab11b is necessary for the trafficking of cGK-II and that the cGMP/cGK-II signaling pathway is closely related to Rab11b recycling pathway.

  18. Basal plasma renin and aldosterone levels were similar in wild-type and cGKII(-/-) mice. In vivo injection of atrio-natriuretic peptide decreased ACTH-stimulated aldosterone secretion in wild-type mice, but had no effect in cGKII-deficient mice.

  19. A novel function for PKG II in osteoblast mechanotransduction, is reported.

Protein Kinase, CGMP-Dependent, Type II (PRKG2) Antigen Profile

Protein Summary

may regulate renin release and renal ion transport

Gene names and symbols associated with PRKG2

  • protein kinase, cGMP-dependent, type II (PRKG2) antibody
  • protein kinase, cGMP-dependent, type II L homeolog (prkg2.L) antibody
  • protein kinase, cGMP-dependent, type II (prkg2) antibody
  • cGMP-dependent protein kinase 2 (LOC100541294) antibody
  • protein kinase, cGMP-dependent, type II (Prkg2) antibody
  • AW212535 antibody
  • cGK-II antibody
  • CGKII antibody
  • GDPKII antibody
  • MGC82580 antibody
  • PRKG2 antibody
  • Prkgr2 antibody
  • si:dkey-18e17.2 antibody

Protein level used designations for PRKG2

protein kinase, cGMP-dependent, type II , cGMP-dependant type II protein kinase , cGMP-dependent protein kinase 2 , cGMP-dependent protein kinase 2-like , cGK 2 , cGK2 , cGMP-dependent protein kinase II , CGK 2 , cGMP dependent protein kinase type II , protein kinase cGMP- dependent type 2 , protein kinase, cGMP- dependent, type 2 , protein kinase, cGMP- dependent, type II , type II cGMP-dependent protein kinase

GENE ID SPECIES
428753 Gallus gallus
444025 Xenopus laevis
461217 Pan troglodytes
487827 Canis lupus familiaris
533330 Bos taurus
696308 Macaca mulatta
100060358 Equus caballus
100125912 Danio rerio
100384937 Callithrix jacchus
100438589 Pongo abelii
100467892 Ailuropoda melanoleuca
100512796 Sus scrofa
100541294 Meleagris gallopavo
100561246 Anolis carolinensis
100584834 Nomascus leucogenys
5593 Homo sapiens
25523 Rattus norvegicus
19092 Mus musculus
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