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Contributes to invasiveness in malignant prostate cancer.. Additionally we are shipping Protein Kinase N3 Proteins (5) and and many more products for this protein.
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Human Polyclonal PKN3 Primary Antibody for WB - ABIN440636
Collazos, Michael, Whelan, Kelly, Mellor, Pang, Totty, Parker: Site recognition and substrate screens for PKN family proteins. in The Biochemical journal 2011
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Steady-state kinetic analysis revealed that PKN1-3 follows a sequential ordered Bi-Bi kinetic mechanism, where peptide substrate binding is preceded by ATP binding. This kinetic mechanism was confirmed by additional kinetic studies for product inhibition and affinity of small molecule inhibitors.
PKN3 is the major regulator of angiogenesis in humans and mice and tumor metastasis in mice.
PKN3 can be considered a novel protein implicated in remodeling the actin-adherens junction, possibly by linking ICAM-1-signaling with actin/AJ dynamics.
PKN isoforms are not simply redundant in supporting migration, but appear to be linked through isoform specific regulatory domain properties to selective upstream signals. It
PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of phosphoinositide 3-kinase
Pkn3 promotes bone resorption downstream of Wnt5a-Ror2-Rho signaling, and this pathway may be a therapeutic target for bone diseases such as osteoporosis, rheumatoid arthritis, and periodontal disease.
Data demonstrate that PKN3 physically interacts with Rho-family GTPases, and preferentially with RhoC, a known mediator of tumor invasion and metastasis in epithelial cancers.
Contributes to invasiveness in malignant prostate cancer.
protein kinase C-like 2
, protein kinase N3
, serine/threonine-protein kinase N3
, serine/threonine-protein kinase N3-like
, protein kinase PKN-beta
, protein-kinase C-related kinase 3
, protein kinase PKNbeta