Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteins (PPM1A)

The protein encoded by PPM1A is a member of the PP2C family of Ser/Thr protein phosphatases. Additionally we are shipping Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Antibodies (100) and Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPM1A 5494 P35813
PPM1A 19042 P49443
PPM1A 24666 P20650
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Top Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$280.00
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$280.50
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Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 14 to 16 Days
$382.80
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Log in to see 8 to 11 Days
$394.90
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 14 to 16 Days
$382.80
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
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Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 11 to 12 Days
$277.22
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

PPM1A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus) ,

More Proteins for Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Interaction Partners

Human Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) interaction partners

  1. PPM1A as a negative threshold regulator of M1-type monocyte-to-macrophage differentiation.

  2. Here the authors establish PPM1A as a checkpoint target used by Mycobacterium tuberculosis to suppress macrophage apoptosis. Overproduction of PPM1A suppressed apoptosis of Mycobacterium tuberculosis-infected macrophages by a mechanism that involves inactivation of the c-Jun N-terminal kinase (JNK).

  3. Present study suggests that HBx-induced degradation of PPM1a is a novel mechanism for over-activation of TGF-beta pathway in HCC development.

  4. Findings show that HCV infection and replication decreased PPM1A abundance, mediated by NS3, in hepatoma cells. Compared to normal liver tissues, the expression of PPM1A was significantly decreased in the HCC tumor tissues and adjacent non-tumor tissues through its regulation by NS3 which promotes its ubiquitination and proteasomal degradation.

  5. These data suggest that PPM1A, which had previously been shown to play a role in the antiviral response to Herpes Simplex virus infection, also governs the antibacterial response of macrophages to bacteria, or at least to Mycobacterium tuberculosis infection

  6. establish PPM1A as a novel repressor of the SMAD3 pathway in renal fibrosis

  7. Report a tumor-suppressive function of PPM1A and an independent relationship to Smad4 in pancreatic ductal adenocarcinoma.

  8. hydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha between the active and inactive states

  9. In a nested case control study of ischemic stroke, there was an epigenome-wide association for cg04985020 (PPM1A; P=1.78x10(-07)) with vascular recurrence in patients treated with aspirin.

  10. findings demonstrate a novel regulatory circuit in which STING and TBK1 reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1

  11. The TGF-beta/Smad signaling system decreases its activity through strong negative regulation. We provide evidence for a new negative feedback loop through PPM1A upregulation.

  12. Loss of PPM1A is associated with the development of tumor invasion in bladder cancer patients.

  13. PPM1A is a RelA phosphatase that regulates NF-kappaB activity and that PPM1A has tumor suppressor-like activity.

  14. a nuclear envelope-localized mechanism of inactivating TGF-beta signaling in which MAN1 competes with transcription factors for binding to Smad2 and Smad3 and facilitates their dephosphorylation by PPM1A.

  15. phosphatase activity toward phosphopeptide substrates by PP2Calpha and Wip1 requires the binding of a Mg(2)+ ion to the low-affinity site.

  16. PPM1A negatively regulates ERK by directly dephosphorylating its pThr202 position early in epidermal growth factor stimulation. Additional kinetic studies reveal that key residues participate in phospho-ERK recognition by PPM1A.

  17. Studies indicate that phosphatase PPM1G is a component of the spliceosome and binds to protein YB-1 to affect alternative splicing.

  18. PPM1A inhibits HIV-1 infection and gene expression. PPM1A depletion in resting CD4+ T cells increases HIV-1 gene expression.

  19. High expression of LMP2 and low expression of PPM1A might play an important role in the motility and invasiveness of trophoblast cells and malignant transformation of hydatidiform mole.

  20. This work demonstrates that PPM1A/PP2Calpha, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFbeta signaling.

Mouse (Murine) Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) interaction partners

  1. VRK1 self-represses its activity to phosphorylate PXR through cyclin-dependent kinase 2 (CDK2) in high glucose conditions, resulting in the repression of the PCK1 gene. This PXR phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2-PXR-PP2Calpha-SGK2 pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.

  2. findings demonstrate a novel regulatory circuit in which STING and TBK1 reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1

  3. the studies presented here position PPM1A as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions

  4. a nuclear envelope-localized mechanism of inactivating TGF-beta signaling in which MAN1 competes with transcription factors for binding to Smad2 and Smad3 and facilitates their dephosphorylation by PPM1A.

  5. Although a non-myristoylated mutation (G2A) of PPM1A and PPM1B prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha.

  6. we found that PPM1A mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A protein

  7. Protein phosphatase PPM1A regulates the nuclear export of Smad2/3 through targeting nuclear exporter RanBP3.

  8. Ppm1a, through suppressing Smad2 signaling, plays a critical role in re-epithelialization during wound healing

  9. Molecular cloning and expression analysis of MPP alpha-2, a novel transcript detected in a differential screen of pituitary libraries (MPPalpha 2)

  10. Protein phosphatase 1alpha is required for lung growth and morphogenesis.

  11. These data suggest that up-regulation of potassium-chloride cotransport in transgenic mouse red cells is mainly secondary to oxidative damage.

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with PPM1A

  • protein phosphatase, Mg2+/Mn2+ dependent 1A (PPM1A)
  • protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (Ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog (ppm1a.L)
  • protein phosphatase, Mg2+/Mn2+ dependent 1A (Ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1Aa (ppm1aa)
  • 2310003C21Rik protein
  • 2900017D14Rik protein
  • AI427932 protein
  • AU017636 protein
  • MMPa-2 protein
  • MPPa-1 protein
  • pp2c-alpha protein
  • Pp2c1 protein
  • pp2ca protein
  • pp2ca2 protein
  • pp2calpha protein

Protein level used designations for PPM1A

protein phosphatase 1A , protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform , Mpp alpha , PP2C-alpha , protein phosphatase 2C isoform alpha , protein phosphatase IA , IA , Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform , Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform , protein phosphatase 1A, magnesium dependent, alpha isoform , protein phosphatase 2C alpha , protein phosphatase type 2C alpha 2

GENE ID SPECIES
5494 Homo sapiens
19042 Mus musculus
24666 Rattus norvegicus
380058 Xenopus laevis
423525 Gallus gallus
480344 Canis lupus familiaris
281994 Bos taurus
100009431 Oryctolagus cuniculus
100738389 Sus scrofa
100734826 Cavia porcellus
30704 Danio rerio
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