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PPM1K encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. Additionally we are shipping PPM1K Antibodies (35) and and many more products for this protein.
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Data show that show that PP2Cm expression is highly enriched in brain, liver, kidney, but low in skeletal muscle.
Branched chain amino acids related genetic variant rs1440581 was associated with an increased risk of incident T2 Diabetes in a Chinese population. This variant might modify effect of weight gain on development in Insulin resistance.
PPM1K rs1440581 may affect changes in glucose metabolism during weight loss, and this effect is dependent on dietary fat and carbohydrate intakes.
miR-204 and miR-211 directly repress PPM1K expression via 3'UTR.
Overweight people with the C allele of the branched-chain amino acid/aromatic amino acid ratio-associated variant rs1440581 may benefit less in weight loss and improved insulin sensitivity than those without it on a energy-restricted high-fat diet.
The 2.4 A PP2Cm structure reveals a central beta-sandwich with two bound metal ions in the active-site cleft.
A novel member of human protein phosphatase 2C gene family named PP2Ckappa was isolated from a human fetal brain cDNA library.
The cloned phosphatase has a mitochondrial leader sequence and its amino acid sequence places it in the PP2C family like two known mitochondrial phosphatases.
This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore.
, protein phosphatase 1K, mitochondrial
, protein phosphatase 2C isoform kappa
, PP2C domain-containing protein phosphatase 1K
, PP2C-type mitochondrial phosphoprotein phosphatase
, branched-chain alpha-ketoacid dehydrogenase phosphatase
, protein phosphatase 2C kappa
, protein phosphatase 1K (PP2C domain containing)