anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) Antibodies

PPP1R1B encodes a bifunctional signal transduction molecule. Additionally we are shipping Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B Kits (9) and Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PPP1R1B 360616 Q6J4I0
PPP1R1B 84152 Q9UD71
PPP1R1B 19049 Q60829
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B Antibodies at antibodies-online.com

Showing 10 out of 212 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Rat Rabbit Un-conjugated WB Western blots of rat caudate lysate showing specific immunolabeling of the ~32k DARPP-32 phosphorylated at Thr34 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the Anti-Thr34 DARPP-32. The immunolabeling is completely eliminated by treatment with (-Ptase. Western blot of rat striatal lysate showing specific immunolabeling of the ~32 kDa DARPP-32 phosphorylated at Thr34 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (λ-Ptase, 1200 units for 30 min). 100 μL Log in to see 3 to 4 Days
$508.20
Details
Human Rabbit Un-conjugated WB Immunolabeling of rat caudate lysates prepared from caudate slices that had been incubated in the absence and presence of okadaic acid.  The labeling by the antibody to DARPP-32 Thr75 is markedly increased by the okadaic acid treatment. Western Blot: DARPP32 [p Thr75] Antibody [ABIN152574] - Analysis of rat caudate lysate showing specific immunolabeling of the ~32k DARPP-32 phosphorylated at Thr75 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase). The blot is identical to the control except that it was incubated (1200 units for 30 min) before being exposed to the Anti-Thr75 DARPP-32. The immunolabeling is completely eliminated by treatment. 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of DARPP32 (pT75) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of DARPP32 (pT75) expression in MDA-MB-361 (A), SHSY5Y (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$575.00
Details
Human Mouse Un-conjugated ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using PPP1R1B mAb against human PPP1R1B (AA: 95-204) recombinant protein. (Expected MW is 38.3 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
$577.50
Details
Rat Rabbit Un-conjugated WB Western blots of rat caudate lysate showing specific immunolabeling of the ~32k DARPP-32 phosphorylated at Thr75 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the Anti-Thr75 DARPP-32. The immunolabeling is completely eliminated by treatment with (-Ptase. Western blot of rat striatal lysate showing specific immunolabeling of the ~32 kDa DARPP-32 phosphorylated at Thr75 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (λ-Ptase, 1200 units for 30 min). 100 μL Log in to see 3 to 4 Days
$508.20
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6267696 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. Western blot analysis of DARPP-32 phosphorylation expression in Forskolin treated COS7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6267697 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. Western blot analysis of Phospho-DARPP-32 (Thr34) expression in various lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details
Cow Rabbit Un-conjugated IC, IF, IHC, WB   200 μL Log in to see 13 to 14 Days
$575.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from 293 cells, treated with EGF 200ng/ml 30', using DARPP-32 (Ab-75) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using DARPP-32 (Ab-75) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COS7 cells treated with Forskolin 40nM 30', using DARPP-32 (Phospho-Thr75) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using DARPP-32 (Phospho-Thr75) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details

Top referenced anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B Antibodies

  1. Human Polyclonal PPP1R1B Primary Antibody for WB - ABIN152574 : Han, Han, Tiwari, Wen, Zheng: Spatial targeting of type II protein kinase A to filopodia mediates the regulation of growth cone guidance by cAMP. in The Journal of cell biology 2007 (PubMed)
    Show all 10 Pubmed References

  2. Rat (Rattus) Polyclonal PPP1R1B Primary Antibody for WB - ABIN361462 : Napolitano, Bonito-Oliva, Federici, Carta, Errico, Magara, Martella, Nistica: Role of aberrant striatal dopamine D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 (PubMed)
    Show all 13 Pubmed References

  3. Mouse (Murine) Polyclonal PPP1R1B Primary Antibody for IHC, WB - ABIN4304299 : Yabuki, Ohizumi, Yokosuka, Mimaki, Fukunaga: Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice. in Neuroscience 2014 (PubMed)
    Show all 4 Pubmed References

  4. Rat (Rattus) Polyclonal PPP1R1B Primary Antibody for WB - ABIN361463 : Gomez, Midde, Mactutus, Booze, Zhu: Environmental enrichment alters nicotine-mediated locomotor sensitization and phosphorylation of DARPP-32 and CREB in rat prefrontal cortex. in PLoS ONE 2012 (PubMed)
    Show all 9 Pubmed References

  5. Cow (Bovine) Polyclonal PPP1R1B Primary Antibody for WB - ABIN550194 : Lindskog, Svenningsson, Pozzi, Kim, Fienberg, Bibb, Fredholm, Nairn, Greengard, Fisone: Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. in Nature 2002 (PubMed)
    Show all 3 Pubmed References

  6. Cow (Bovine) Polyclonal PPP1R1B Primary Antibody for WB - ABIN550193 : Svenningsson, Tzavara, Witkin, Fienberg, Nomikos, Greengard: Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac). in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 3 Pubmed References

  7. Chicken Polyclonal PPP1R1B Primary Antibody for ICC, IF - ABIN550150 : Maldve, Zhang, Ferrani-Kile, Schreiber, Lippmann, Snyder, Fienberg, Leslie, Gonzales, Morrisett: DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens. in Nature neuroscience 2002 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal PPP1R1B Primary Antibody for ELISA, WB - ABIN1724915 : Hamel, Bouchard, Ferrario, Hassan, Aguilar-Mahecha, Buchanan, Quenneville, Miller, Basik: Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers. in Breast cancer research and treatment 2010 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal PPP1R1B Primary Antibody for FACS, ELISA - ABIN1724929 : Kunii, Ikemoto, Wada, Yang, Kusakabe, Suzuki, Niwa: Detailed DARPP-32 expression profiles in postmortem brains from patients with schizophrenia: an immunohistochemical study. in Medical molecular morphology 2011 (PubMed)
    Show all 2 Pubmed References

  10. Human Polyclonal PPP1R1B Primary Antibody for IHC (p), IHC - ABIN152638 : Shioda, Han, Moriguchi, Fukunaga: Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia. in Journal of neurochemistry 2007 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B Interaction Partners

Rhesus Monkey Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) interaction partners

  1. DARPP-32 and I-1 were most frequently identified in dendritic shafts, unlike the D1R and PP1 isoforms. Moreover, DARPP-32 and I-1 were only present in approximately 4% and 8% of area 9 pyramidal cell spines, respectively.

Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) interaction partners

  1. Single nucleotide polymorphisms related to dopamine are associated with individual differences in exploration strategies. Variation in a gene linked to prefrontal dopamine (COMT) predicted the degree of directed exploration, as well as the overall randomness of responding. Variation in a gene linked to striatal dopamine (DARPP-32) predicted the degree of both directed and random exploration.

  2. t-Darpp phosphorylation at T39 seems to be crucial for t-Darpp-mediated PKA activation and this activation appears to occur through an association with RI and sequestering of RI away from PKAc. The t-Darpp-RI interaction could be a druggable target to reduce PKA activity in drug-resistant cancer.

  3. our results lend support for a potential role of DARPP-32 genetic variants in neural response to potential reward triggering cues

  4. To facilitate live-cell identification, a human embryonic stem cell line was generated using CRISPR-mediated gene editing at the DARPP32 locus.

  5. Study associates polymorphisms in DRD2, DARPP-32, and COMT genes with novel category learning performance. Modeling results suggest that striatal dopaminergic genes influence selective attention processes whereas cortical genes mediate the ability to update complex rule representations.

  6. Results show that expression of human DARPP-32 protein isoforms depends on the striatal neurodevelopmental stage with t-DARPP being specific for the human adult striatum.

  7. In vivo xenograft models demonstrated that overexpression of DARPP-32 promotes angiogenesis and tumour growth.

  8. This study strongly suggests that inflammation-regulated DARPP-32 constitutes a key component of H. pylori-mediated gastric tumourigenesis.

  9. This study did not find any statistical difference in the state-anxiety dimension for the rs12601930C/T, rs879606A/G, and rs3764352A/G genotypes, but statistical differences in the trait-anxiety dimension for the rs879606A/G (F = 5.207, P = 0.006) and rs3764352A/G (F = 3.960, P = 0.020) genotype.

  10. DARPP-32 is mainly cleaved at Thr(153) by calpain and this cleavage of DARPP-32 reduces CREB phosphorylation via loss of its inhibitory function on PP1; results suggest a novel mechanism of DARPP-32-CREB signalling dysregulation in Alzheimer's disease

  11. No significant differences in mRNA expression levels of DRD2 and DARPP-32 were found among controls, patients with psychotic disorder not otherwise specified, and schizophrenia/schizophreniform disorder.

  12. Striatal function was indexed by a gene coding for DARPP-32, which is densely expressed in the striatum where it is necessary for synaptic plasticity

  13. Findings show that PPP1R1B-STARD3 fusion transcript has a key role in subsets of gastric cancers through the activation of PI3K/AKT signaling.

  14. The results of this study found that the mean t-DARPP expression level in the caudate was higher in patients with schizophrenia than in control individuals.

  15. Results suggest that variation in PPP1R1B affects the abundance of the splice variant t-DARPP-32 mRNA and may reflect potential molecular mechanisms implicated in schizophrenia and affective disorders

  16. The immunostaining was more decreased for DARPP-32 than for the morphological changes of striatal neurons in multiple system atrophy.

  17. This study showed that variations in genotypes relevant for DARPP-32 functions are associated more with aging-related impairments in the explicit than the implicit component of sequence learning.

  18. density of DARPP-32-immunoreactive (IR) neurons in the II and III layers of the RAIC was significantly decreased (p<0.05) in the schizophrenia group compared with the healthy control group.

  19. Bcl-2 and DARPP-32 have roles in regulating inositol 1,4,5-trisphosphate receptor phosphorylation and promoting cell survival

  20. High DARPP32/STAT3, DARPP32/STAT5B, and STAT5B/STAT3 ratios were associated with longer patient progression free survival.

Mouse (Murine) Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) interaction partners

  1. This study strongly suggests that inflammation-regulated DARPP-32 constitutes a key component of H. pylori-mediated gastric tumourigenesis.

  2. the results suggest that by inducing dephosphorylation of DARPP-32 at Ser-97 and altering its cytonuclear distribution, glutamate may counteract dopamine/D1 receptor/PKA signaling at multiple cellular levels.

  3. Darpp32 interaction with beta-adducin may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system.

  4. Results show that Darpp-32 was expressed in normal mouse mammary tissue and in some breast tumors, whereas t-Darpp was found exclusively in mammry tumors.

  5. analysis of cAMP-activated DARPP-32 signalling to the nucleus

  6. Results describe the development of new vascular mouse model with a conditional knockout allele of Tsc1 with a Darpp32-Cre allele. This mouse displayed accelerated formation of both kidney cystadenomas and paw hemangiosarcomas.

  7. Cannabinoid-stimulated G-protein activity did not differ between DARPP-32 KO and WT mice treated with vehicle or repeated THC.

  8. In this work, the dissected postsynaptic topology of the DARPP-32 phosphoprotein provides strong evidence for a compartmentalized and confined distribution in dendritic spines.

  9. Adenosine AA receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation.

  10. Data suggest that histone deacetylase inhibitors inhibit the induction of NGF1A-binding protein Nab2 by brain derived neurotrophic factor (BDNF), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein, 32 kDa (DARPP-32).

  11. This study demonistrated that environment enhanced Darpp32 expression in brain and enhanced totaroad perfermance and short term working menory.

  12. DARPP32 has a role in pluripotent stem cell differentiation toward medium-sized spiny neurons

  13. l-DOPA-induced activation of ERK and mTORC1 requires DARPP-32 and indicates the importance of the cAMP/DARPP-32 signaling cascade in dyskinesia.

  14. DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib.

  15. Data show that the loss of DARPP-32 in striatopallidal neurons produced a robust increase in locomotor activity.

  16. results indicate that under chronic dopamine deficiency (a) the A(2A)/cAMP/PKA/DARPP-32 cascade is overactive due to the elevated endogenous phospho-DARPP-32 levels and (b) the A(2A) receptor modulatory effect on ERK1/2 signaling is dysregulated

  17. Our data demonstrate that beta(1)- and alpha(2)-adrenoceptors regulate DARPP-32 phosphorylation in neostriatal neurons.

  18. Data confirmed that CR specifically increased dopamine- and cAMP-regulated phosphoprotein (Darpp-32), a key regulator of dopamine receptor signaling, in the amygdala.

  19. DARPP-32 is essential not only for dopaminergic but also for serotonergic neurotransmission.

  20. stimulatory effect of caffeine on motor activity in mice was greatly reduced following genetic deletion of DARPP-32 (dopamine- and cyclic AMP-regulated phosphoprotein of relative molecular mass 32,000)

Xenopus laevis Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) interaction partners

  1. Areas of brain and spinal cord that are densely innervated by tyrosine hydroxylase-immunoreactive fibers display a remarkable immunoreactivity for DARPP-32/ppp1r1b in cell bodies and neuropil.

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) Antigen Profile

Protein Summary

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PPP1R1B

  • protein phosphatase 1 regulatory inhibitor subunit 1B (ppp1r1b) antibody
  • protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B) antibody
  • protein phosphatase 1, regulatory (inhibitor) subunit 1B (Ppp1r1b) antibody
  • protein phosphatase 1 regulatory inhibitor subunit 1B S homeolog (ppp1r1b.S) antibody
  • AU040756 antibody
  • DARPP-32 antibody
  • DARPP32 antibody

Protein level used designations for PPP1R1B

protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32) , neuronal phosphoprotein DARPP-32 , protein phosphatase 1 regulatory subunit 1B , protein phosphatase 1, regulatory (inhibitor) subunit 1B , dopamine- and cAMP-regulated neuronal phosphoprotein , dopamine- and cAMP-regulated phosphoprotein DARPP-32 , dopamine and cAMP-regulated neuronal phosphoprotein 32 , DARPP-32 , dopamine and cAMP regulated

GENE ID SPECIES
100124928 Xenopus (Silurana) tropicalis
574203 Macaca mulatta
608394 Canis lupus familiaris
744755 Pan troglodytes
100355399 Oryctolagus cuniculus
100736966 Sus scrofa
360616 Rattus norvegicus
84152 Homo sapiens
19049 Mus musculus
733416 Xenopus laevis
282459 Bos taurus
Selected quality suppliers for anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) Antibodies
Did you look for something else?