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The protein encoded by PPP1R16B is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Additionally we are shipping Protein Phosphatase 1, Regulatory Subunit 16B Antibodies (33) and many more products for this protein.
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TIMAP is suppressed by TGFbeta (show TGFB1 Proteins) via HDAC3 (show HDAC3 Proteins)-associated Smad (show SMAD1 Proteins) signaling.
These data confirmed the barrier-protective role of TIMAP
NF2 (show NF2 Proteins) localizes in nucleus when Ser518 is not phosphorylated, while phosphorylated form is present in cytoplasm and plasma membrane. Data suggest that binding of NF2 (show NF2 Proteins) to TIMAP and EBP50 (show SLC9A3R1 Proteins) is critical in nuclear localization of NF2 (show NF2 Proteins). (NF2 (show NF2 Proteins) = neurofibromin 2 (show NF2 Proteins); TIMAP = TGF-beta-inhibited membrane-associated protein; EBP50 (show SLC9A3R1 Proteins) = Ezrin (show EZR Proteins)-Radixin (show RDX Proteins)-Mosein binding phosphoprotein 50)
phosphorylation of TIMAP on Ser331 by PKC (show PRRT2 Proteins) represents a new mechanism of endothelial barrier regulation, through the inhibition of phospho-ERM (show ETV5 Proteins) dephosphorylation
Results indicate that PKC (show PRRT2 Proteins)-phosphorylated ECE-1 (show ECE1 Proteins) is a TIMAP-PP1c substrate and this phosphatase complex has an important role in endothelin-1 (show EDN1 Proteins) production of EC through the regulation of ECE-1 (show ECE1 Proteins) activity.
ROCK phosphorylated eEF1A1 (show EEF1A1 Proteins) is a novel substrate for TIMAP-PP1 (show PPA1 Proteins) underlining the complex regulatory role of TIMAP in the endothelium.
TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt (show AKT1 Proteins) inhibition in human glomerular endothelial cells.
Data suggest that double-thiophosphorylation of TIMAP has minor effect on its binding ability to PP1c, but considerably attenuates its inhibitory effect on the activity of PP1c.
TIMAP, a novel CAAX box protein regulated by TGF-beta1 (show TGFB1 Proteins) and expressed in endothelial cells.
involvement of TIMAP in PKA-mediated moesin (show MSN Proteins) dephosphorylation and the importance of this dephosphorylation in TIMAP-mediated endothelial cell barrier protection
TIMAP can modify protein phosphorylation independent of its function as a PP1c regulatory subunit, namely by masking phosphorylation sites of binding partners like PP1c and LAMR1 (show RPSA Proteins).
TIMAP is a target for PKA-primed GSK-3beta-mediated phosphorylation. This phosphorylation controls TIMAP association and activity of PP1c
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
CAAX box protein TIMAP
, TGF-beta-inhibited membrane-associated protein
, protein phosphatase 1 regulatory inhibitor subunit 16B
, whn-dependent transcript 4
, ankyrin repeat domain protein 4
, ankyrin repeat domain-containing protein 4
, protein phosphatase 1, regulatory (inhibitor) subunit 16B