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Regulatory subunit of protein phosphatase 1 (By similarity).. Additionally we are shipping Protein Phosphatase 1, Regulatory Subunit 7 Proteins (8) and and many more products for this protein.
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Schizosaccharomyces pombe Polyclonal PPP1R7 Primary Antibody for IF, IP - ABIN2452121
Ohkura, Yanagida: S. pombe gene sds22+ essential for a midmitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-1. in Cell 1991
Show all 3 Pubmed References
a Fra-1-miR-134 axis drives a positive feedback loop that amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells.
Mechanistically, the phosphorylation of Sds22 by PLK1 strengthens the binding of Sds22 to PP1 and inhibits the dephosphorylation of Thr(232) of Aurora B to ensure a robust, error-free metaphase-anaphase transition.
there is a second, parallel signalling pathway which triggers the relaxation of the polar cell cortex at mid anaphase--independent of furrow formation, centrosomes and microtubules, pathway depends on PP1 phosphatase and regulatory subunit Sds22
a model in which I3 regulates an SDS22-mediated PP1 activation step in solution that precedes SDS22 dissociation and transfer of PP1 to kinetochores, and which is required for PP1 to efficiently antagonize Aurora B.
It was shown that Repo-Man and Sds22 contribute to timely Aurora B kinase substrate dephosphorylation on anaphase chromatin.
human Sds22 is focally deleted and downregulated in multiple carcinomas, and this downregulation correlates with tumor progression, suggesting that sds22 inactivation may contribute to tumorigenesis and metastatic potential
Sds22 specifically defines protein phosphatase 1 function and localization in mitosis.
Sds22 and Inhibitor-3 form a heterotrimeric complex with PP1, both in cell lysates and after purification. A pool of PP1 is complexly controlled by both Sds22 and Inhibitor-3.
Regulatory subunit of protein phosphatase 1 (By similarity).
protein phosphatase 1 regulatory subunit 22
, protein phosphatase 1 regulatory subunit 7
, protein phosphatase-1 regulatory subunit 7
, protein phosphatase 1, regulatory (inhibitor) subunit 7
, protein phosphatase-1 regulatory subunit 7 alpha2
, protein phosphatase-1 regulatory subunit 7 beta1
, protein phosphatase-1 regulatory subunit 7 beta2