PPP4C Proteins
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration.
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Protein Phosphatase 4, Catalytic Subunit (PPP4C) (AA 2-307) protein (His tag) Protein
Protein Phosphatase 4, Catalytic Subunit (PPP4C) (AA 2-307) protein (His tag) Protein
Protein Phosphatase 4, Catalytic Subunit (PPP4C) protein (His tag) Protein
Protein Phosphatase 4, Catalytic Subunit (PPP4C) (AA 1-307) protein (GST tag) Protein
Protein Phosphatase 4, Catalytic Subunit (PPP4C) (AA 218-307) protein (GST tag) Protein
Protein Phosphatase 4, Catalytic Subunit (PPP4C) (AA 1-307) protein (His tag) Protein
Protein Phosphatase 4, Catalytic Subunit (PPP4C) Protein Protein
Protein Phosphatase 4, Catalytic Subunit (PPP4C) (AA 2-307) protein (His tag) Protein
Protein Phosphatase 4, Catalytic Subunit (PPP4C) (AA 2-307) protein (His tag) Protein
Protein Phosphatase 4, Catalytic Subunit (PPP4C) (AA 2-307) protein (His tag) Protein
PPP4C Protein Profile
Protein Summary
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Gene names and symbols associated with PPP4C
- protein phosphatase 4 catalytic subunit (ppp4c) antibody
- protein phosphatase 4, catalytic subunit a (ppp4ca) antibody
- protein phosphatase 4 catalytic subunit (PPP4C) antibody
- protein phosphatase 4, catalytic subunit (Ppp4c) antibody
- protein phosphatase 4 catalytic subunit S homeolog (ppp4c.S) antibody
- 1110002D08Rik antibody
- AU016079 antibody
- gc:56413 antibody
- MGC75928 antibody
- PP4 antibody
- PP4C antibody
- PP4C-A antibody
- PPH3 antibody
- PPP4 antibody
- ppp4c antibody
- Ppx antibody
- wu:fd05e08 antibody
- zgc:56413 antibody
Protein level used designations for PPP4C
protein phosphatase 4, catalytic subunit , catalytic subunit , serine/threonine-protein phosphatase 4 catalytic subunit A , PP-X , protein phosphatase 4 (formerly X), catalytic subunit , protein phosphatase X, catalytic subunit , serine/threonine-protein phosphatase 4 catalytic subunit , PP4C , pp4 , protein phosphatase X
| GENE ID | SPECIES |
|---|---|
| 394540 | Xenopus (Silurana) tropicalis |
| 100003080 | Danio rerio |
| 5531 | Homo sapiens |
| 540398 | Bos taurus |
| 56420 | Mus musculus |
| 171366 | Rattus norvegicus |
| 489947 | Canis lupus familiaris |
| 100009163 | Oryctolagus cuniculus |
| 432334 | Xenopus laevis |
| 100173513 | Pongo abelii |
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