anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) Antibodies

May regulates the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (By similarity).. Additionally we are shipping Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) Proteins (11) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTPN5 29644 P35234
PTPN5 19259 P54830
PTPN5 84867 P54829
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Top anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) Antibodies at antibodies-online.com

Showing 10 out of 104 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ICC, IHC (fro), IF, IP, IHC, WB Western Blot analysis of STEP protein in striatal rat protein homogenates, using ABIN152543. Immunohistochemistry-Paraffin: STEP Antibody (23E5)  - STEP was detected in immersion fixed paraffin-embedded sections of human brain basal ganglia using Mouse Anti-Human STEP (23E5) Monoclonal Antibody . Specific staining was localized to the cytoplasm in neurons. 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PTPN5 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  HT1080 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of hSTEP-Q155 (ABIN392843) in HepG2 cell line lysates (35 µg/lane). STEP (arrow) was detected using the purified polyclonal antibody. Western blot analysis of hSTEP-Q155 (ABIN392843) in mouse brain tissue lysates (35 µg/lane). STEP (arrow) was detected using the purified polyclonal antibody 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated IHC, IHC (p), WB Anti-PTPN5 / STEP antibody IHC staining of human spleen, red pulp. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN957777 dilution 1:200. Anti-PTPN5 / STEP antibody IHC of human spleen, red pulp. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200. 50 μL Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB PTPN5 Antibody (N-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PTPN5 antibody detected the PTPN5 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC (p), IHC, WB Immunohistochemistry-Paraffin: STEP Antibody [NBP1-33388] - Paraffin-embedded A549 xenograft, using antibody at 1:500 dilution. Western Blot: STEP Antibody [NBP1-33388] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$516.98
Details
Human Mouse Un-conjugated WB Western Blot analysis of PTPN5 expression in transfected 293T cell line by PTPN5 MaxPab polyclonal antibody.Lane 1: PTPN5 transfected lysate(62.15 KDa).Lane 2: Non-transfected lysate. PTPN5 MaxPab polyclonal antibody. Western Blot analysis of PTPN5 expression in K-562. 50 μL Log in to see 11 to 12 Days
$440.00
Details

Top referenced anti-Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) Antibodies

  1. Human Monoclonal PTPN5 Primary Antibody for ICC, IHC (fro) - ABIN152543 : Boulanger, Lombroso, Raghunathan, During, Wahle, Naegele: Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1995 (PubMed)
    Show all 34 Pubmed References

  2. Monoclonal PTPN5 Primary Antibody for WB - ABIN534126 : Choi, Lin, Lee, Kurup, Cho, Naegele, Lombroso, Obrietan: Status epilepticus-induced somatostatinergic hilar interneuron degeneration is regulated by striatal enriched protein tyrosine phosphatase. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal PTPN5 Primary Antibody for WB - ABIN534380 : Eswaran, von Kries, Marsden, Longman, Debreczeni, Ugochukwu, Turnbull, Lee, Knapp, Barr: Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. in The Biochemical journal 2006 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal PTPN5 Primary Antibody for IHC (p), ELISA - ABIN545034 : Li, Luna, Lombroso, Francke: Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci. in Genomics 1996 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) Interaction Partners

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) interaction partners

  1. STEP plays an important role at nerve terminals in the regulation of Ca(2+) homeostasis and neurotransmitter release.

  2. STEP61 degradation is an important event in BDNF-mediated effects.

  3. STEP has a key role in the regulation of psychomotor action and physical dependency to morphine. These data suggest that STEP inhibition may be a critical target for the treatment of withdrawal symptoms associated with morphine.

  4. This study demonistrated that behavioral, molecular, and electrophysiological data indicate that spinal STEP61 plays a regulatory role in nociception.

  5. STEP61 regulates BDNF expression, with implications for cognitive functioning in CNS disorders.

  6. The study provides further insight into the mechanisms of regulation of STEP61 and also offers a molecular basis for the Zn(2+)-induced sustained activation of ERK2.

  7. STEP contributes, at least in part, to the protection against the ingestion of aversive agents.

  8. These results indicate that STEP61 is a novel substrate of parkin, although further studies are necessary to determine whether elevated STEP61 levels directly contribute to the pathophysiology of PD.

  9. Abeta regulating STEP61 activity is mediated by Abeta binding to alpha7 nAChRs

  10. Increased STEP and calpain activation contribute to altered NMDAR localization in an Huntington's disease mouse model.

  11. genetically reducing STEP significantly diminishes seizures and restores select social and nonsocial anxiety-related behaviors in Fmr1(KO) mice

  12. the first study to identify Pyk2 as a substrate for STEP.

  13. Increased STEP61 plays a role in amyloid Abeta-mediated internalization of the (AMPAR) subunits GluA1/GluA2 (formerly GluR1/GluR2).

  14. The absence of STEP improves cognitive performance, and may do so by the regulation of downstream effectors necessary for synaptic transmission.

  15. STEP pathway is severely downregulated in the presence of mutant huntingtin and may participate in compensatory mechanisms activated by striatal neurons that lead to resistance to excitotoxicity.

  16. STEP may be required for ethanol's amnesic effects.

  17. Electrical stimulation of the hippocampal-entorhinal cortex pathway in STEP knockout mice resulted in less activation of the dentate gyrus granule cell layer (GCL), but greater activation of the hilus in STEP knockouts, compared with heterozygous slices.

  18. genetic manipulations to reduce STEP activity in a triple transgenic AD mouse model and show that a decrease in STEP levels reverses cognitive and cellular deficits observed in these mice.

  19. These results suggest that STEP is an important mediator in the dopamine D2R-mediated activation of ERK signaling and in the regulation of dopaminergic neuronal development.

  20. results reveal a novel mechanism by which Abeta-mediated accumulation of STEP61 results in increased internalization of NR1/NR2B receptor that may contribute to the cognitive deficits in Alzheimer's disease

Human Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) interaction partners

  1. validated the functional importance of an identified interaction network by characterizing a distinct novel interaction between PTPN5 and Mob1a.

  2. This current study demonstrated that spinal STEP61 regulated LTP of C fiber-evoked field potentials, one of the extensively studied cellular models of central sensitization.

  3. a dual role for PSD-95 in stabilizing synaptic NMDARs by binding directly to GluN2B but also by promoting synaptic exclusion and degradation of the negative regulator STEP61.

  4. STEP is involved in the mechanism of depressive disorders and it is a promising molecular target for atypical antidepressant drugs of new generation. (Review)

  5. Data suggest that PP5/PTPN5 is overexpressed in liver samples from patients with hepatocellular carcinoma (HCC); overexpression of PP5/PTPN5 appears to correlate with tumor burden/stage. Inhibition of PP5/PTPN5 suppresses proliferation and promotes apoptosis of HCC cells; inhibition of PP5/PTPN5 involves activation of AMPK.

  6. A rare missense variant in the PTPN5 gene (rs56234898; minor allele frequency 1.5%) was significantly associated with decreased severity of Post-Burn Hypertrophic Scarring(P = 1.3x10-6).

  7. STEP levels are unchanged in pre-frontal cortex and associative striatum in post-mortem human brain samples from subjects with schizophrenia, bipolar disorder and major depressive disorder

  8. Article focuses on the most recent findings on STEP, discuss how STEP expression and activity are maintained during normal cognitive function, and how disruptions in STEP activity contribute to a number of illnesses. [Review]

  9. Decreased STEP protein activation in corpus striatum contributes to early enhanced apoptotic signaling in YAC model transgenic mice.

  10. This experiments demonstrated that deletion of STEP can enhance experience-induced neuroplasticity and memory formation

  11. The results imply a model in which PTPN5 may play a role in normal cognitive functioning and contribute to aspects of the neuropathology of schizophrenia.

  12. This study identified a novel role for PTPN5 in mediating the development of stress-related cognitive and morphological changes.

  13. STEP(61kDa) is required for Abeta transgene-mediated internalization of GluA1/GluA2 glutamate receptors in a transgenic mousemodel.

  14. STEP contributes to aspects of the pathophysiology in Alzheimer's disease; loss of GluN1/GluN2B subunits from neuronal membranes and Abeta-mediated NMDAR internalization are discussed

  15. findings show that STEP(61) levels are progressively increased in the prefrontal cortex of Alzheimer disease brains

  16. determined high-resolution structures of all of the human family members of Mitogen-Activated Protein Kinase-specific protein tyrosine phosphatases

  17. in colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency

Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5) Antigen Profile

Protein Summary

May regulates the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (By similarity).

Gene names and symbols associated with PTPN5

  • protein tyrosine phosphatase, non-receptor type 5 (ptpn5) antibody
  • protein tyrosine phosphatase, non-receptor type 5 (PTPN5) antibody
  • protein tyrosine phosphatase, non-receptor type 5 (Ptpn5) antibody
  • PTPSTEP antibody
  • Step antibody

Protein level used designations for PTPN5

protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) , tyrosine-protein phosphatase non-receptor type 5 , neural-specific protein-tyrosine phosphatase , protein-tyrosine phosphatase striatum-enriched , protein-tyrosine-phosphatase non-receptor 5 , striatum-enriched protein-tyrosine phosphatase

GENE ID SPECIES
559524 Danio rerio
423085 Gallus gallus
615850 Bos taurus
29644 Rattus norvegicus
19259 Mus musculus
84867 Homo sapiens
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