anti-Protein tyrosine Phosphatase, Receptor Type, A (PTPRA) Antibodies

Human Protein tyrosine Phosphatase, Receptor Type, A (PTPRA) interaction partners

1. Multivariate Cox regression analysis suggested that PTPRA expression was an independent prognostic factor in SCC patients. In the cellular models, PTPRA promotes SCC cell proliferation through modulating Src activation as well as cell cycle progression. In conclusion, higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression

2. VacA mediates CagA phosphorylation through RPTPalpha in AZ-521 cells.

3. A receptor type-protein tyrosine phosphatase alpha-Src family kinase-Rap1 pathway was identified as responsible for recruiting myosin IIB to the zonula adherens in epithelial cells and supporting contractile tension.

4. no evidence was seen for the association of rare, missense mutations in the PTPRA gene with schizophrenia or autism spectrum disorders

5. Data indicate that scaffold protein RACK1 plays a role in IGF-1-mediated protein-tyrosine phosphatase alpha (PTPalpha) tyrosine phosphorylation in MCF-7 Cells.

6. recruited to epithelial adherens junctions for cadherin-dependent cell adhesion and tissue architecture formation

7. Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis.

8. new role for PTPalpha in the regulation of motility of mammary epithelial cells in response to ErbB2 activation.

9. results suggest that PTPalpha links activation of epidermal growth factor receptor (EGFR) signaling with Src activation and may provide a novel therapeutic target for treatment of breast cancer.

10. A single-nucleotide polymorphism (rs6138953) on the PTPRA gene in the 20p13 region was found to be associated with elevated fasting glucose level.

11. The extracellular proteolytic processing is a novel mechanism for PTPalpha regulation.

12. our results suggest that plasma PTPalpha and fibronectin may be associated with opisthorchiasis.

13. convergent evidence reported here links RPTP to schizophrenia.

14. The transformed cells were tumourigenic in nude mice, suggesting that RPTPalpha245-induced activation of Src in the human tumours may have contributed to carcinogenesis.

15. the PTPalpha-mediated increase of NB-3 level at the cell surface represents a novel function of PTPalpha in NB-3 signaling in neural development

16. a novel role for E-loop residue Lys182 in enhancing HePTP catalytic activity through its interaction with Asp236 of the WPD loop was revealed.

17. IL-1-induced signaling through focal adhesions leading to MMP3 release and interactions between SHP-2 and PTPalpha are dependent on the integrity of the catalytic domains of PTPalpha.

18. force-responsive proteins such as RPTPalpha can influence cancer-cell behavior and identify potential targets for cancer therapy.

19. Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.

20. In entering mitosis the cell cycle-specific regulation of c-Src by RPTPalpha can occur by dephosphorylation of phospho-Tyr527 that activates c-Src in a reaction catalyzed by the transmembrane receptor-like protein tyrosine phosphatase RPTPalpha.

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, A (PTPRA) interaction partners

1. PTPalpha coordinates oligodendroglial and neuronal development and myelination.

2. RPTPalpha mediates proinflammatory and proinvasive signaling in rheumatoid arthritis fibroblast-like synoviocytes (FLS), correlating with the promotion of disease in an FLS-dependent model of rheumatoid arthritis.

3. Ptpra coordinates the regulation of the Fyn signaling pathway in corpus striatum.

4. PTPs alpha and epsilon play distinct roles in osteoclasts.

5. PTP-alpha promotes profibrotic signaling pathways in fibroblasts through control of cellular responsiveness to TGF-beta.

6. The focal adhesion targeting domain of FAK interacts with protein-tyrosine phosphatase-alpha to restrict IL1-induced Ca2+ release, ERK activation, and MMP-9 expression.

7. PTPalpha may be involved in the formation of axoglial junctions and ensheathment in small axons during myelination of the spinal cord.

8. Findings indicate Grb2 as a new FAK activator and in coordinating PTPalpha tyrosine phosphorylation to enable downstream integrin signaling and migration.

9. Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis.

10. Inflammation-induced connective tissue degradation involving fibroblasts requires functionally active PTPalpha.

11. study described a molecular complex of PTPalpha-BCAR3-Cas-Src; this complex forms in response to PTPalpha Tyr789 phosphorylation and mediates Cas localization to focal adhesions and Cas downstream signaling to promote cell migration

12. Protein-tyrosine phosphatase alpha acts in oligodendrocyte progenitor cells to limit self-renewal and facilitate differentiation.

13. protein kinase C and protein tyrosine phosphatase alpha participate in Src activation by 1alpha,25OH2 vitamin D3 in C2C12 skeletal muscle cells

14. the PTPalpha-mediated increase of NB-3 level at the cell surface represents a novel function of PTPalpha in NB-3 signaling in neural development

15. these findings indicate that PTPalpha acts as an Ag-stimulated Lyn-Fyn phosphatase and a critical positive regulator of these Src family kinases in FcepsilonRI signaling

16. The results suggest that transformation by PTPalpha involves at least one function other than, or in addition to, its activation of Src and that this depends on PTPalpha's extracellular domain.

17. Expression of CD45RA and -RC isoforms is increased 20- to 200-fold on T cells from mice with a loss-of-function mutation in RNA-binding protein heterogeneous nuclear ribonucleoprotein L-like, although total CD45 expression is unaltered.

18. Results describe the role of nitric oxide in regulating the focal adhesion proteins, Src, FAK, p130 Cas, and PTP-alpha.

19. IL-1-induced signaling through focal adhesions leading to MMP3 release and interactions between SHP-2 and PTPalpha are dependent on the integrity of the catalytic domains of PTPalpha.

20. A new model for mitotic activation of Src in which PP2A-mediated dephosphorylation of RPTPalpha pSer204 facilitates Src binding, is proposed.

Zebrafish Protein tyrosine Phosphatase, Receptor Type, A (PTPRA) interaction partners

1. ptpra protein, zebrafish, signaling is essential for convergence and extension cell movements during gastrulation.