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PTPRZ1 encodes a member of the receptor protein tyrosine phosphatase family. Additionally we are shipping Protein tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 Proteins (4) and Protein tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 Kits (1) and many more products for this protein.
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Human Monoclonal PTPRZ1 Primary Antibody for BI, IF - ABIN967798
Krueger, Saito: A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. in Proceedings of the National Academy of Sciences of the United States of America 1992
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Human Monoclonal PTPRZ1 Primary Antibody for BI, IF - ABIN967799
Levy, Canoll, Silvennoinen, Barnea, Morse, Honegger, Huang, Cannizzaro, Park, Druck: The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. in The Journal of biological chemistry 1993
Show all 5 Pubmed References
Authors characterized exosomes from GBM cells harbouring and not harbouring PTPRZ1-MET fusion (ZM fusion).
these data indicate that PTN (show PTN Antibodies)-PTPRZ-A signaling controls the timing of oligodendrocyte precursor cell differentiation in vivo, in which the CS moiety of PTPRZ receptors maintains them in a monomeric active state until its ligand binding.
PTPRZ1 is affected in a contiguous gene deletion syndrome
Confirm contribution of PTPRZ1, and especially PTPRQ, in CRC carcinogenesis and demonstrated that PTPRQ expression is correlated with KRAS mutation.
Data indicate that enhanced MET oncoprotein RNA expression by fusion with receptor-type tyrosine-protein phosphatase zeta (PTPRZ1).
Data indicate that the fusion arose from translocation events involving introns 3 or 8 of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) and intron 1 of hepatocyte growth factor receptor MET.
Distinct domains of PTPRZ-B are differentially required for migration and proliferation of glioma cells, respectively.
High expression of PTP receptors R and Z1 was observed in all examined cases of colorectal carcinoma, adenoma and normal colon tissue in this study.
Protein tyrosine phosphatase (show ACP1 Antibodies) zeta enhances proliferation by increasing beta-catenin (show CTNNB1 Antibodies) nuclear expression in VHL (show VHL Antibodies)-inactive human renal cell carcinoma (show MOK Antibodies) cells.
Data suggest that CSF-1R (show CSF1R Antibodies)-independent actions of IL-34 (show IL34 Antibodies) via receptor-type protein-tyrosine phosphatase (show ACP1 Antibodies) zeta (PTP-zeta) might be considered in evaluating IL-34 (show IL34 Antibodies) roles in development and disease.
These results suggest that sub-isoforms of PTPRZ have different functions because of variations in the wedge structure.
The Protein Tyrosine Phosphatase (show ACP1 Antibodies) Rptpzeta Suppresses Osteosarcoma Development in Trp53 (show TP53 Antibodies)-Heterozygous Mice
The Pleiotrophin (show PTN Antibodies)-induced inactivation of PTPRZ was considered to be the adaptive mechanism underlying CNS remyelination in vivo.
Abnormal glycosylation of RPTP-zeta/phosphacan is neural cell-specific and may play a role in congenital muscular dystrophies.
Ptprz plays a negative role in oligodendrocyte differentiation in early central nervous system (CNS) development and remyelination in demyelinating CNS diseases.
RPTPbeta/zeta is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes.
Ptprz is necessary to maintain central nervous system axonal integrity in a demyelinating environment.
Loss of RPTPZ promotes prostate cancer metastasi.
spatial and temporal expression patterns of O-mannosylated forms of RPTPzeta/phosphacan and its hypoglycosylation are suggestive of a role in the neural phenotypes observed in Congenital muscular dystrophies
This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
protein tyrosine phosphatase, receptor-type, zeta polypeptide 1
, protein-tyrosine phosphatase receptor type Z polypeptide 2
, receptor-type tyrosine phosphatase beta/zeta
, receptor-type tyrosine-protein phosphatase zeta
, 3F8 chondroitin sulfate proteoglycan
, 3H1 keratan sulfate proteoglycan
, PTP zeta
, protein tyrosine phosphate, receptor type, Z
, phosphotyrosyl phosphatase