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Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate.
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h-Prune expression is necessary for cancer cell motility and EMT (show ITK Proteins) and is associated with liver and lung metastasis in colorectal cancer cells. h-Prune could be a new prognostic marker and molecular target for CRLM.
Data indicate that the D388A and D422A mutant h-Prune proteins interact weakly with Nm23-H1 (show NME1 Proteins).
GSK-3 and h-prune cooperatively regulate the disassembly of focal adhesions to promote cell migration and that h-prune is useful as a marker for tumor aggressiveness.
A therapeutic approach to treat prostate cancer by targeting Nm23-H1 (show NME1 Proteins)/h-Prune interaction
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1 (By similarity).
prune homolog (Drosophila)
, prune homolog
, protein prune homolog
, Drosophila-related expressed sequence 17