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May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells (By similarity)..
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E2F1 (show E2F1 Proteins) directly facilitated BMCC1 transcription. These results also suggest that BMCC1 induced by E2F1 (show E2F1 Proteins) acts as a tumor suppressor through its pro-apoptotic function, resulted in favorable prognosis of neuroblastoma (show ARHGEF16 Proteins).
Results show prostate cancer antigen 3 (show CTAG1B Proteins) (PCA3) as a dominant-negative oncogene (show RAB1A Proteins) and PRUNE2 protein as an unrecognized tumor suppressor gene in prostate cancer.
BMCC1 negatively regulates phosphorylation pathway of AKT (show AKT1 Proteins), resulted in apoptosis and the BNIP2 (show BNIP2 Proteins) homology region of BMCC1 interacts with BCL2 (show BCL2 Proteins).
recurrent germ line and somatic mutations in PRUNE2 were found in parathyroid carcinoma and computationally predicted to be deleterious; in addition, recurrent mutations in kinase genes related to cell migration and invasion were found.
BMCC1 is an AP-2 (show GTF3A Proteins) associated endosomal protein in prostate cancer cells.
We showed that Olfaxin, a novel Prune2 isoform contains a BCH (show CHN2 Proteins) motif and localizes predominantly to the synaptic cytosol in the olfactory bulb and layer Ia of the piriform cortex.
PRUNE2 expression is correlated with the survival of leiomyosarcoma patients. Non-coding RNA PCA3 has a significant positive correlation with PRUNE2 and may play an important role in the pathogenesis of leiomyosarcoma.
The nerve tissue-specific and post-development expression of PRUNE2/Prune2 suggests that PRUNE2 may contribute to the maintenance of mature nervous systems.
BMCC1 is a new member of prognostic factors for NBL (show NUMBL Proteins) and may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells
OBSCN (show OBSCN Proteins) and C9orf65 comprise a highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas.
kidney-type glutaminase (KGA (show GLS Proteins)) as a novel partner of Bmcc1s
This study identifies Bmcc1s as a new MAP6 (show MAP6 Proteins) interacting protein able to modulate MAP6 (show MAP6 Proteins)-induced microtubule cold stability.
Prune2 mRNA is predominantly expressed in the neurons of the cranial nerve motor nuclei and the motor neurons of the spinal cord
May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells (By similarity).
prune homolog 2 (Drosophila)
, BNIP2 motif containing molecule at the carboxyl terminal region 1
, BCH motif-containing molecule at the carboxyl terminal region 1
, BNIP2 motif-containing molecule at the C-terminal region 1
, protein prune homolog 2
, truncated PRUNE2