anti-Pseudopodium-Enriched Atypical Kinase 1 (PEAK1) Antibodies

Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. Additionally we are shipping PEAK1 Kits (4) and PEAK1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PEAK1 79834 Q9H792
PEAK1 244895 Q69Z38
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Top anti-PEAK1 Antibodies at antibodies-online.com

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB   200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: PEAK1 Antibody [NBP1-91052] - Staining of human stomach shows strong cytoplasmic and nuclear positivity in glandular cells. Immunocytochemistry/Immunofluorescence: PEAK1 Antibody [NBP1-91052] - Staining of human cell line U-251MG shows positivity in nucleus but not nucleoli, plasma membrane & cytoplasm. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6275647 staining NIH-3T3 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB SGK269 Antibody (N-term)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the SGK269 antibody detected the SGK269 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated IF, ELISA, WB Immunofluorescence of monoclonal antibody to KIAA2002 on HeLa cell. [antibody concentration 10 ug/ml] KIAA2002 monoclonal antibody (M02), clone 3E7 Western Blot analysis of KIAA2002 expression in MCF-7 . 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis in K562 cell line lysates (35ug/lane). Mouse Sgk269 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded mouse stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 200 μL Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ELISA, WB KIAA2002 monoclonal antibody (M03), clone 3G6 Western Blot analysis of KIAA2002 expression in HeLa . Detection limit for recombinant GST tagged KIAA2002 is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$440.00
Details

Top referenced anti-PEAK1 Antibodies

  1. Human Monoclonal PEAK1 Primary Antibody for ELISA, WB - ABIN566389 : Leroy, Fialin, Sirvent, Simon, Urbach, Poncet, Robert, Jouin, Roche: Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells. in Cancer research 2009 (PubMed)

More Antibodies against PEAK1 Interaction Partners

Human Pseudopodium-Enriched Atypical Kinase 1 (PEAK1) interaction partners

  1. PEAK1's kinase cleft is occluded, and its newly identified SHED region may promote an unexpected dimerization mode. Similarities of PEAK1 with the active kinase PINK1 may reclassify the latter as a member of the new kinase family 3 group.

  2. the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9.

  3. Findings indicate that eIF5A-PEAK1-YAP signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity.

  4. report is the first to provide evidence that PEAK1 mediates signaling cross talk between TGFbeta receptors and integrin/Src/MAPK pathways and that PEAK1 is an important molecular regulator of TGFbeta-induced tumor progression and metastasis in breast cancer

  5. this regard, we have demonstrated that PEAK1 is necessary for TGFbeta to induce ZEB1-mediated EMT in the context of fibronectin/ITGB3 activation.

  6. Suggest that loss of PEAK1/E-cadherin may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition.

  7. eIF5A proteins utilize PEAK1 as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis.

  8. results define a novel signaling pathway in basal breast cancer involving Lyn and SgK269 that offers clinical opportunities for therapeutic intervention

  9. phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover

  10. Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN).

  11. Also known as SgK269. Contains a divergent and possibly inactive eukaryotic protein kinase domain. Has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms

PEAK1 Antigen Profile

Protein Summary

Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN (By similarity).

Gene names and symbols associated with PEAK1

  • pseudopodium enriched atypical kinase 1 (PEAK1) antibody
  • pseudopodium-enriched atypical kinase 1 (Peak1) antibody
  • 1110049L02Rik antibody
  • 9530046P14 antibody
  • AA690169 antibody
  • BE132841 antibody
  • mKIAA2002 antibody
  • Peak1 antibody
  • SGK269 antibody

Protein level used designations for PEAK1

pseudopodium enriched atypical kinase , pseudopodium-enriched atypical kinase 1 , sugen kinase 269 , tyrosine-protein kinase SgK269 , NKF3 kinase family member

GENE ID SPECIES
79834 Homo sapiens
244895 Mus musculus
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