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Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. Additionally we are shipping PEAK1 Kits (4) and PEAK1 Proteins (4) and many more products for this protein.
Showing 10 out of 56 products:
Human Monoclonal PEAK1 Primary Antibody for ELISA, WB - ABIN566389
Leroy, Fialin, Sirvent, Simon, Urbach, Poncet, Robert, Jouin, Roche: Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells. in Cancer research 2009
the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9.
Findings indicate that eIF5A (show EIF5 Antibodies)-PEAK1-YAP (show YAP1 Antibodies) signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity.
report is the first to provide evidence that PEAK1 mediates signaling cross talk between TGFbeta (show TGFB1 Antibodies) receptors and integrin/Src (show SRC Antibodies)/MAPK (show MAPK1 Antibodies) pathways and that PEAK1 is an important molecular regulator of TGFbeta (show TGFB1 Antibodies)-induced tumor progression and metastasis in breast cancer
this regard, we have demonstrated that PEAK1 is necessary for TGFbeta (show TGFB1 Antibodies) to induce ZEB1 (show ZEB1 Antibodies)-mediated EMT (show ITK Antibodies) in the context of fibronectin (show FN1 Antibodies)/ITGB3 (show ITGB3 Antibodies) activation.
Suggest that loss of PEAK1/E-cadherin (show CDH1 Antibodies) may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition.
eIF5A (show EIF5 Antibodies) proteins utilize PEAK1 as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis.
results define a novel signaling pathway in basal breast cancer involving Lyn (show LYN Antibodies) and SgK269 that offers clinical opportunities for therapeutic intervention
phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover
Here, we report that the novel tyrosine kinase (show TXK Antibodies) PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN).
Also known as SgK269. Contains a divergent and possibly inactive eukaryotic protein kinase domain. Has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms
Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN (By similarity).
pseudopodium enriched atypical kinase
, pseudopodium-enriched atypical kinase 1
, sugen kinase 269
, tyrosine-protein kinase SgK269
, NKF3 kinase family member