Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha Proteins (PCBD1)

PCBD1 encodes pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. Additionally we are shipping PCBD1 Antibodies (53) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCBD1 13180 P61458
PCBD1 5092 P61457
PCBD1 29700 P61459
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Top PCBD1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$522.50
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Log in to see 4 to 8 Days
$504.90
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$547.80
Details
Yeast Human His tag 100 μg Log in to see 8 to 11 Days
$484.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$400.00
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,185.33
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,185.33
Details

PCBD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, ,
Rat (Rattus)

More Proteins for Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha (PCBD1) Interaction Partners

Mouse (Murine) Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha (PCBD1) interaction partners

  1. DCoH acts as a cofactor for HNF1 that stabilizes the dimeric HNF1 complex.

  2. HNF1alpha binding kinetics may distinguish regulation by DCoH2, under thermodynamic control, from regulation by DCoH, under kinetic control

Human Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha (PCBD1) interaction partners

  1. We provide the first genetic evidence that PCBD1 mutations can cause early-onset nonautoimmune diabetes with features similar to dominantly inherited HNF1A-diabetes.

  2. Coactivator of the HNFB1 (HNF1 homeobox B)-mediated transcription is necessary for fine tuning ATPase Na+/K+ transporting gamma 1 polypeptide (FXYD2) transcription in the distal convoluted tubule

  3. Pcbd1 is a moonlighting protein that has dehydratase activity in addition to functioning as a cofactor which regulates HNF1alpha.

  4. variants of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2) and the dimerization cofactor of HNF-1 (DcoH/PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function

  5. Data reveal DCoH/HNF-1 alpha expression and transcriptional activity in human epidermal melanocytes in vitro and in situ and identified tyrosinase, the key enzyme for pigmentation, as a new transcriptional target.

  6. Albumin colocalized together with its transcription factor PCD/DCoH/HNF-1alpha in suprabasal keratinocytes in human full-thickness skin sections and in keratinocytes cultured in serum-free medium.

  7. Properties of dehydratase/DCoHalpha are consistent with hypothesis that activity of this isozyme could account for relatively mild symptoms reported for patients with a defect in dehydratase/DCoH

PCBD1 Protein Profile

Protein Summary

This gene encodes pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1).

Gene names and symbols associated with PCBD1

  • pterin-4a-carbinolamine dehydratase (Pcd)
  • pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (pcbd1)
  • pterin-4-alpha-carbinolamine dehydratase (Tb11.02.4890)
  • pterin-4-alpha-carbinolamine dehydratase (pcbd)
  • pterin-4-alpha-carbinolamine dehydratase (Fbal_2579)
  • pterin-4-alpha-carbinolamine dehydratase (Ftrac_2004)
  • pterin-4-alpha-carbinolamine dehydratase (Celal_2911)
  • pterin-4-alpha-carbinolamine dehydratase (Isop_1133)
  • pterin-4-alpha-carbinolamine dehydratase (Celly_0291)
  • pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 (Pcbd1)
  • pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha L homeolog (pcbd1.L)
  • pterin-4 alpha-carbinolamine dehydratase 1 (PCBD1)
  • pterin-4 alpha-carbinolamine dehydratase 1 (Pcbd1)
  • BcDNA:LP07248 protein
  • CG1963 protein
  • DCoH protein
  • DDBDRAFT_0204977 protein
  • DDBDRAFT_0305045 protein
  • DDB_0204977 protein
  • DDB_0305045 protein
  • Dmel\\CG1963 protein
  • PCBD protein
  • pcd protein
  • PHS protein
  • TCF1 protein
  • Xdcoh protein
  • zgc:73389 protein

Protein level used designations for PCBD1

CG1963-PA , Pcd-PA , pterin-4-alpha-carbinolamine dehydratase , 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) , 4-alpha-hydroxy-tetrahydropterin dehydratase , PCD , PHS , dimerization cofactor of HNF1 , dimerization cofactor of hepatocyte nuclear factor 1-alpha , dimerization cofactor of hepatocyte nuclear factor-1-alpha , phenylalanine hydroxylase-stimulating protein , pterin carbinolamine dehydratase , DCoH , XDCoH , 6-pyruvoyl-tetrahydropterin synthase , cDcoH , pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) , dimerizing cofactor for HNF1 , pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1

GENE ID SPECIES
43499 Drosophila melanogaster
393787 Danio rerio
496425 Xenopus (Silurana) tropicalis
3665797 Trypanosoma brucei brucei strain 927/4 GUTat10.1
8623790 Dictyostelium discoideum AX4
9771410 Ferrimonas balearica DSM 9799
10012150 Marivirga tractuosa DSM 4126
10145334 Cellulophaga algicola DSM 14237
10155246 Isosphaera pallida ATCC 43644
10262275 Cellulophaga lytica DSM 7489
13180 Mus musculus
397951 Xenopus laevis
395729 Gallus gallus
5092 Homo sapiens
530736 Bos taurus
29700 Rattus norvegicus
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