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PYCR2 belongs to the pyrroline-5-carboxylate reductase family. Additionally we are shipping Pyrroline-5-Carboxylate Reductase Family, Member 2 Antibodies (63) and many more products for this protein.
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PYCR2-related syndrome represents a clinically recognizable condition in which PYCR2 mutations lead to protein dysfunction.
It was found that silence of PYCR2 resulted in the decrease of proliferative ability and activation of AMPK/mTOR-induced autophagy of A375 cells. PYCR2 silencing also activated AMPK/mTOR pathway in another melanoma cell line, CHL-1.
Silencing of both PYCR1 (show PYCR1 Proteins) and PYCR2 completely abolished anti-oxidation activity of RRM2B (show RRM2B Proteins), demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress.
Hypomyelination and the absence of lax (show LAX1 Proteins) caused by previously reported mutations in the gene encoding PYCR2's isozyme, PYCR1 (show PYCR1 Proteins), suggesting a unique and indispensable role for PYCR2 in the human CNS during development.
This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene.
pyrroline-5-carboxylate reductase family, member 2
, pyrroline-5-carboxylate reductase 2
, putative pyrroline-5-carboxylate reductase family member 2 variant 1
, P5C reductase 2
, pyrroline 5-carboxylate reductase isoform
, P5CR 2
, pyrroline-5-carboxylate reductase