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R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1\; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008].. Additionally we are shipping R-Spondin 2 Antibodies (27) and R-Spondin 2 Proteins (9) and many more products for this protein.
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RSPO2 is a novel target gene of the NOBOX key transcription factor, confirming its important role during the follicular growth in ovary. However, RSPO2 mutations are rare or uncommon in women with primary ovarian insufficiency.
Novel targets ANTXR1 (show ANTXR1 ELISA Kits) and RSPO2 were confirmed to be suppressed by miR (show MLXIP ELISA Kits)-493 directly.
RSPOs facilitate HSC activation and promote liver fibrogenesis by enhancing the Wnt (show WNT2 ELISA Kits) pathway
Role of RSPO2 in gastric cancer
RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a (show WNT5A ELISA Kits)/Fzd7-driven noncanonical Wnt (show WNT2 ELISA Kits) pathway.
genetic and functional data indicate that RSPO2 is a susceptibility gene for OPLL (show COL6A1 ELISA Kits) (Ossification of the Posterior Longitudinal Ligament of the Spine)
Rspo2 was found to have a negative regulatory effect during oxidized low density lipoproteininduced macrophage apoptosis by regulating lipid uptake.
data reveal a RSPO2-induced, LGR5 (show LGR5 ELISA Kits)-dependent Wnt (show WNT2 ELISA Kits) signaling-negative feedback loop that exerts a net growth-suppressive effect on CRC (show CALR ELISA Kits) cells
results suggest that the expression of RSPO (show RSPO1 ELISA Kits) fusion transcripts is related to a subset of colorectal cancers arising in the Japanese population
Wnt (show WNT2 ELISA Kits)(high) cells were more likely to give rise to Wnt (show WNT2 ELISA Kits)(high) progeny, tended to be more metastatic, and revealed higher levels of RSPO2 expression.
Data report that Rspo2, is highly expressed in the spinal motor neuron (SMN (show STMN1 ELISA Kits)) and binds to its receptor Lgr5 (show LGR5 ELISA Kits), at the neuromuscular junction (NMJ). Rspo2 enhances the LRP4 (show CORIN ELISA Kits)/MuSK (show MUSK ELISA Kits) signaling via Lgr5 (show LGR5 ELISA Kits) in an agrin (show AGRN ELISA Kits)-independent manner and promotes AChR clustering. In addition, the loss of Rspo2 in mice compromises AChR clustering, the ultrastructure of the NMJ, and neuromuscular signal transduction.
LGR4 (show LGR4 ELISA Kits) acted as a key receptor for Rspo2 to promote osteogenesis.
Rspo2 activates Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling to reduce Col2a1 (show COL2A1 ELISA Kits) and Sox9 (show SOX9 ELISA Kits) and to facilitate differentiation of proliferating chondrocytes into hypertrophic chondrocytes in growth cartilage
High resolution crystal structure of an ectodomain variant of human LGR5 (show LGR5 ELISA Kits) (hLGR5ecto) complexed with a signalling competent fragment of mouse Rspo2.
The endogenously expressed Lgr4 (show LGR4 ELISA Kits) may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin (show NDP ELISA Kits)-mediated Lgr4 (show LGR4 ELISA Kits)-Wnt (show WNT2 ELISA Kits) signaling during gonadal development.
These findings suggest that R-Spondin2 may promote hepatic stellate cell activation by enhancing the canonical Wnt (show WNT2 ELISA Kits) pathway.
identify the transforming growth factor beta antagonist follistatin (show FST ELISA Kits) as a key mediator of RSPO (show RSPO1 ELISA Kits)-LGR4 (show LGR4 ELISA Kits) signaling in myogenic differentiation
Rspo2 is required to limit the number of outer hair cells to three rows and for optimal arrangement of peripheral nerve fibers in the developing cochlea.
Rspo2 mutation in combination with Rspo3 (show RSPO3 ELISA Kits) mutation causes severe limb truncation.
Recombinant R-spondin2 and Wnt3a (show WNT3A ELISA Kits) up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells.
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1\; MIM 116806) signaling (Kim et al., 2006
, roof plate-specific spondin-2
, activator of Wnt/beta-catenin pathway
, R-spondin 2 homolog
, R-spondin 2
, cysteine-rich and single thrombospondin domain-containing protein 2