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In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. Additionally we are shipping RAB35 Proteins (7) and RAB35 Kits (3) and many more products for this protein.
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Cow (Bovine) Polyclonal RAB35 Primary Antibody for WB - ABIN2784851
Kley, Maerkens, Leber, Theis, Schreiner, van der Ven, Uszkoreit, Stephan, Eulitz, Euler, Kirschner, Müller, Meyer, Tegenthoff, Fürst, Vorgerd, Müller, Marcus: A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients. in Molecular & cellular proteomics : MCP 2012
Hamster Polyclonal RAB35 Primary Antibody for ICC, IF - ABIN4348921
Dikshit, Bist, Fenlon, Pulloor, Chua, Scidmore, Carlyon, Tang, Chen, Sukumaran: Intracellular Uropathogenic E. coli Exploits Host Rab35 for Iron Acquisition and Survival within Urinary Bladder Cells. in PLoS pathogens 2015
The authors propose that Rab35-GTP (show AK3 Antibodies) is a critical regulator of autophagy through recruiting autophagy receptor NDP52 (show CALCOCO2 Antibodies).
The results provide evidence that MICAL1 (show MICAL1 Antibodies) plays an essential role in the activation of ROS (show ROS1 Antibodies)/Akt (show AKT1 Antibodies) signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 (show MICAL1 Antibodies) in regulating breast cancer cell invasion.
The involvement of Rab35 in diverse and apparently unrelated cellular functions can be explained by the central role of this GTPase in regulating phosphoinositides and F-actin, both on endosomes and at the plasma membrane[review].
Data suggest that Rab35, interacting with TBC1D10A (show TBC1D10A Antibodies), functions in vascular endothelial cells as a negative regulator of histamine-evoked, Ca2 (show CA2 Antibodies)+-dependent Weibel-Palade body exocytosis, most likely acting through the downstream effectors ACAP2 (show ACAP2 Antibodies) and Arf6 (show ARF6 Antibodies). (Rab35 = rab (show HRB Antibodies) GTP-binding protein (show HCAR3 Antibodies) 53 (show IGFBP3 Antibodies); TBC1D10A (show TBC1D10A Antibodies) = TBC1 domain family member 10A (show TBC1D10A Antibodies); ACAP2 (show ACAP2 Antibodies) = centaurin beta2; Arf6 (show ARF6 Antibodies) = ADP-ribosylation factor 6 (show ARF6 Antibodies))
Short-term EGF (show EGF Antibodies) stimulation if of lung tumor cells can increase the interaction between RUSC2 (show RUSC2 Antibodies) and GIT2 (show GIT2 Antibodies), prolonged stimulation leads to a decrease of their interaction through activating Rab35.
Here the authors report that EspG interacts specifically with the small GTPases ARF6 (show ARF6 Antibodies) and Rab35 during infection.
Authors propose that the precise spatial and temporal activation of Rab35 acts as a major switch for OCRL (show OCRL Antibodies) recruitment on newborn endosomes, post-scission PtdIns(4,5)P2 hydrolysis, and subsequent endosomal trafficking.
Rab35 serves as a clathrin-mediated endocytosis detector. Loss of Rab35 input leads to elevated Arf6-GTP and shifts the sorting of clathrin-independent endocytosis cargo proteins to lysosomes.
the activation-inactivation cycles of Rab35 and ARF6 (show ARF6 Antibodies) are required for the uptake of zymosan and that ACAP2 (show ACAP2 Antibodies) is an important component that links Rab35/ARF6 (show ARF6 Antibodies) signaling during phagocytosis of zymosan.
Two somatic RAB35 mutations found in human tumors generate alleles that constitutively activate PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling, suppress apoptosis, and transform cells in a PI3K (show PIK3CA Antibodies)-dependent manner.
This study demonstrated that Rab35 regulates Cdc42 (show CDC42 Antibodies) activity in neurons.
The Rab35 plays an important role in spindle organization and morphology maintenance, and thus meiotic nuclear maturation.
Rab35 regulates myoblast fusion, a major cellular process under the control of cadherin-dependent signaling.
Rab35 regulates phagosome formation through recruitment of ACAP2 (show ACAP2 Antibodies) in macrophages during FcgammaR-mediated phagocytosis.
The minimal functional Rab35-binding site of RUSC2 (show RUSC2 Antibodies) was identified at the amino acid residues 982-1199 and succeeded in developing a novel GTP (show AK3 Antibodies)-Rab35-specific trapper.
Rab35 colocalizes with actin filaments and with Cdc42 (show CDC42 Antibodies), Rac1 (show RAC1 Antibodies) and RhoA (show RHOA Antibodies), and that Rab35 can activate Cdc42 (show CDC42 Antibodies) both in vivo and in vitro
study found that Rab35 regulates the assembly of actin filaments in filopodia formation; effect was mediated by the actin-bundling protein fascin (show FSCN1 Antibodies), which directly associated with active Rab35
In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge.
RAB35, member RAS oncogene family
, ras-related protein Rab-35
, GTP-binding protein RAY
, ras-related protein rab-1c (GTP-binding protein ray)