RAD17 Homolog (S. Pombe) Proteins (RAD17)

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

• RAD17 checkpoint clamp loader component (RAD17)
• RAD17 checkpoint clamp loader component (rad17)
• Rad17p (RAD17)
• RADIATION SENSITIVE 17 (ATRAD17)
• RAD17 checkpoint clamp loader component (Rad17)

• 9430035O09Rik protein
• CCYC protein
• HRAD17 protein
• K2A18.21 protein
• K2A18_21 protein
• Show all synonym aliases
• MmRad24 protein
• R24L protein
• RAD17 protein
• RAD17SP protein
• RAD24 protein
• RADIATION SENSITIVE 17 protein
• zgc:91969 protein

RAD17 homolog (S. pombe) , cell cycle checkpoint protein RAD17-like , cell cycle checkpoint protein RAD17 , Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins , Rad17p , RAD17 homolog , Cell cycle checkpoint protein RAD17 , RAD1 homolog , RF-C activator 1 homolog , RF-C/activator 1 homolog , Rad17-like protein , cell cycle checkpoint protein (RAD17)