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May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Additionally we are shipping RAD51AP1 Antibodies (46) and many more products for this protein.
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The current understanding of the biochemical and biological functions of RAD51AP1 as HR factor is reviewed. It is also discussed how RAD51AP1 may help to promote cancer development and potentially be a promising new target for therapeutic intervention. [REVIEW]
USP1 (show USP1 Proteins)-UAF1 (show WDR48 Proteins) complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1.
RAD51AP1 is required for the maintenance of DNA replication fork progression.
Data suggest that microRNA/mRNA pairs in hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-140-3p/RAD51AP1/, hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-145/E2F3, hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-139-5p/TOP2A (show TOP2A Proteins), and hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-133a/GCLC (show GCLC Proteins) were correlated with ovarian tumorigenesis.
We have finely mapped the two DNA binding domains in RAD51AP1 and using mutant variants, reveal that both domains are indispensable for RAD51AP1 function in cells.
RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase (show RAG1 Proteins) DMC1 (show DMC1 Proteins) through a conserved motif.
RAD51AP1 foci colocalize with a subset of DMC1 (show DMC1 Proteins) foci in spermatocytes.
Although PALB2 (show PALB2 Proteins) alone stimulates D-loop formation, it has a cooperative effect with RAD51AP1, an enhancer of RAD51 (show RAD51 Proteins).
expression of three (Beclin 1 (show BECN1 Proteins), RbAp48 (show RBBP4 Proteins) and Pir51) were increased and one (aldolase b (show ALDOB Proteins)) was decreased in liver tumor tissues
RAD51AP1 has a selective affinity for branched-DNA structures that are obligatory intermediates during joint molecule formation.
VipD of Legionella pneumophila targets activated Rab5 (show RAB5A Proteins) and Rab22 to interfere with endosomal trafficking in macrophages.
May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA (By similarity).
RAD51-associated protein 1
, RAD51-interacting protein