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Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Additionally we are shipping RHNO1 Kits (3) and many more products for this protein.
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Knockdown of RHINO in human cells partially abrogated ATR (show ANTXR1 Proteins)-Chk1 (show CHEK1 Proteins) kinase signaling following UV irradiation but did not impact the loading of Rad9 (show RAD9A Proteins)-Hus1 (show HUS1 Proteins)-Rad1 (show ERCC4 Proteins) complex on chromatin or the association of Rad9 (show RAD9A Proteins)-Hus1 (show HUS1 Proteins)-Rad1 (show ERCC4 Proteins) complex with TopBP1 (show TOPBP1 Proteins).
Germline variation in the RHINO gene is unlikely to influence inherited susceptibility to breast cancer.
We suggest that RHINO functions together with the 9-1-1 complex and TopBP1 to fully activate ATR (ataxia telangiectasia and Rad3-related.
Identified C12orf32 to be significantly up-regulated in the great majority of clinical breast cancer specimens.
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition of breat cancer cells. Plays a role in the stimulation of CHEK1 phosphorylation.
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
, Rad9, Rad1, Hus1 interacting nuclear orphan
, rAD9, RAD1, HUS1-interacting nuclear orphan protein