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Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Additionally we are shipping RHNO1 Kits (3) and many more products for this protein.
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Knockdown of RHINO in human cells partially abrogated ATR-Chk1 kinase signaling following UV irradiation but did not impact the loading of Rad9-Hus1-Rad1 complex on chromatin or the association of Rad9-Hus1-Rad1 complex with TopBP1.
Germline variation in the RHINO gene is unlikely to influence inherited susceptibility to breast cancer.
We suggest that RHINO functions together with the 9-1-1 complex and TopBP1 to fully activate ATR (ataxia telangiectasia and Rad3-related.
Identified C12orf32 to be significantly up-regulated in the great majority of clinical breast cancer specimens.
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition of breat cancer cells. Plays a role in the stimulation of CHEK1 phosphorylation.
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
, Rad9, Rad1, Hus1 interacting nuclear orphan
, rAD9, RAD1, HUS1-interacting nuclear orphan protein