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RAP1GAP encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein.
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Human Polyclonal RAP1GAP Primary Antibody for ICC, IF - ABIN4349349
Mulder, Björling, Jonasson, Wernérus, Hober, Hökfelt, Uhlén: Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. in Molecular & cellular proteomics : MCP 2009
results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity
Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC (show CYLD Antibodies)).
Rap1GAP is ubiquitinated and degraded through proteasome pathway in mitosis. Rap1GAP interacts with PLK1 (show PLK1 Antibodies) in vivo.
kidney biopsies from glomerulosclerosis patients exhibited increased RAP1GAP, resulting in diminished glomerular RAP1 activation
findings identify Rap1GAP as a critical regulator of aggressive tumor cell behavior and suggest that the level of Rap1GAP expression influences the migratory mechanisms that are operative in tumor cells.
Results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro.
Downregulation of RAP1GAP in thyroid tumors enhances SRC (show SRC Antibodies)-dependent signals that regulate cellular architecture and motility.
Over-expression of Rap1GAP attenuated levels of both cadherins and integrins that are known to regulate the cancer cells invasion in renal cel carcinoma.
Rap1GAP is a more effective inhibitor of cell-matrix adhesion compared to cell-cell adhesion.
A polycomb (show CBX2 Antibodies)-mediated repression of rap1GAP was demonstrated that involves EZH2 (show EZH2 Antibodies), a histone methyltransferase in head and neck cancers. It was also shown that the loss of miR (show MLXIP Antibodies)-101 expression correlates with EZH2 (show EZH2 Antibodies) upregulation and rap1GAP downregulation.
increased podocyte expression of RAP1GAP contributes directly to podocyte dysfunction by a mechanism that involves loss of RAP1-mediated activation of beta1 integrin
Plexins are GTPase (show RACGAP1 Antibodies)-activating proteins for Rap (show LRPAP1 Antibodies) and are activated by induced dimerization
Ca2 (show CA2 Antibodies)+-dependent monomer and dimer formation switches CAPRI (show RASA4 Antibodies) Protein between Ras GTPase-activating protein (show RASA1 Antibodies) (GAP) and RapGAP activities
ERK activation by cAMP does not require RAP1
evidence of differential Krit1 (show KRIT1 Antibodies) and Rap1A (show RAP1A Antibodies) expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1 (show KRIT1 Antibodies), not restricted to vascular endothelial cells.
Rap1 (show TERF2IP Antibodies) couples cAMP signaling to a distinct pool of p42 (show EPB42 Antibodies)/44MAPK regulating excitability, synaptic plasticity, learning, and memory.
Expression studies show that mr-gef (show RAPGEF5 Antibodies) is expressed by young neurons of the developing rodent CNS but not by progenitor cells in the ventricular zone (VZ).
down-regulation of Rap1 (show TERF2IP Antibodies) expression following somatostatin (show SST Antibodies) treatment is closely related to the diminished LFA-1 (show ITGAL Antibodies) expression
forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling
EGF (show EGF Antibodies)-induced activation of GTPase (show RACGAP1 Antibodies) Rap1 (show TERF2IP Antibodies) was sensitized in NIH3T3/EGFR (show EGFR Antibodies)-e3B1 (show ABI1 Antibodies) cells.
a proper level of Rap1 is crucial for heart morphogenesis and function.
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.
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, GTPase activating protein 1
, GTPase activating protein Rap1-GAP
, RAP1, GTPase activating protein 1
, Rap1 GTPase-activating protein 1