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RIOK3 was identified by the similarity of its product to the Aspergillus nidulans SUDD protein, an extragenic suppressor of the heat-sensitive bimD6 mutation that fails to attach properly to the spindle microtubules at a restrictive temperature. Additionally we are shipping RRIO Kinase 3 Antibodies (47) and RRIO Kinase 3 Proteins (6) and many more products for this protein.
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RIO kinase 3 (RIOK3) positively regulates the activity of the AKT/mTOR pathway in glioma cells.
the ectopic expression of RIOK3 or a phosphomimetic MDA5-S828D mutation attenuated MDA5-mediated signaling.
These findings demonstrate that RIOK3 is necessary for maintaining actin cytoskeletal organisation required for migration and invasion, biological processes that are necessary for hypoxia-driven metastasis.
Functionally, RIOK3 acts as a SUFU-dependent positive regulator of Hedgehog signaling.
Authors found that RIOK3 physically interacts with TBK1 and IRF3 and bridges the functions between TBK1 and IRF3 in the activation of type I interferon pathway.
RioK3 is a novel cytoplasmic component of pre-40S pre-ribosomal particle(s) in human cells, required for normal processing of the 21S pre-rRNA.
Like RIOK3, PAK4 promotes pancreas ductal cell motility and invasion in pancreatic cancer
This gene was identified by the similarity of its product to the Aspergillus nidulans SUDD protein, an extragenic suppressor of the heat-sensitive bimD6 mutation that fails to attach properly to the spindle microtubules at a restrictive temperature. The specific function of this gene has not yet been determined.
homolog of the Aspergillus nidulans sudD gene product
, serine/threonine-protein kinase RIO3
, sudD (suppressor of bimD6, Aspergillus nidulans) homolog
, sudD homolog
, sudD suppressor of Aspergillus nidulans bimD6 homolog
, sudD suppressor of bimD6 homolog
, sudD, suppressor of bimD6 homolog
, RIO kinase 3