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RIOK3 was identified by the similarity of its product to the Aspergillus nidulans SUDD protein, an extragenic suppressor of the heat-sensitive bimD6 mutation that fails to attach properly to the spindle microtubules at a restrictive temperature.
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the ectopic expression of RIOK3 or a phosphomimetic MDA5 (show IFIH1 ELISA Kits)-S828D mutation attenuated MDA5 (show IFIH1 ELISA Kits)-mediated signaling.
These findings demonstrate that RIOK3 is necessary for maintaining actin cytoskeletal organisation required for migration and invasion, biological processes that are necessary for hypoxia-driven metastasis.
Functionally, RIOK3 acts as a SUFU-dependent positive regulator of Hedgehog (show SHH ELISA Kits) signaling.
Authors found that RIOK3 physically interacts with TBK1 (show TBK1 ELISA Kits) and IRF3 (show IRF3 ELISA Kits) and bridges the functions between TBK1 (show TBK1 ELISA Kits) and IRF3 (show IRF3 ELISA Kits) in the activation of type I interferon (show IFNA ELISA Kits) pathway.
RioK3 is a novel cytoplasmic component of pre-40S pre-ribosomal particle(s) in human cells, required for normal processing of the 21S pre-rRNA.
Like RIOK3, PAK4 (show PAK4 ELISA Kits) promotes pancreas ductal cell motility and invasion in pancreatic cancer
down-regulation of miR (show MLXIP ELISA Kits)-191 is essential for erythroid chromatin condensation and enucleation by allowing up-regulation of Riok3 and Mxi1 (show MXI1 ELISA Kits)
This gene was identified by the similarity of its product to the Aspergillus nidulans SUDD protein, an extragenic suppressor of the heat-sensitive bimD6 mutation that fails to attach properly to the spindle microtubules at a restrictive temperature. The specific function of this gene has not yet been determined.
homolog of the Aspergillus nidulans sudD gene product
, serine/threonine-protein kinase RIO3
, sudD (suppressor of bimD6, Aspergillus nidulans) homolog
, sudD homolog
, sudD suppressor of Aspergillus nidulans bimD6 homolog
, sudD suppressor of bimD6 homolog
, sudD, suppressor of bimD6 homolog
, RIO kinase 3