anti-RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) Antibodies

The protein encoded by RBCK1 is similar to mouse UIP28/UbcM4 interacting protein. Additionally we are shipping RBCK1 Kits (6) and RBCK1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RBCK1 10616 Q9BYM8
RBCK1 24105 Q9WUB0
RBCK1 60383 Q62921
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Top anti-RBCK1 Antibodies at antibodies-online.com

Showing 10 out of 78 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-C20orf18 Antibody Titration:  1.25ug/ml  Positive Control:  Jurkat cell lysate RBCK1 is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL 2 to 3 Days
$229.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged C20orf18 is approximately 0.03ng/ml as a capture antibody. Western Blot analysis of C20orf18 expression in transfected 293T cell line by C20orf18 monoclonal antibody (M01), clone 3C3.Lane 1: C20orf18 transfected lysate(25.7 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC (p), WB Antibody is used in Western blot to detect UBCE7IP3 in mouse kidney tissue lysate. RBCK1 (UBCE7IP3) Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human bladder carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RBCK1 (UBCE7IP3) Antibody for immunohistochemistry. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Lane 1: Mouse uterus lysate, Lane 2: mouse overy lysate probed with RBCK1 Polyclonal Antibody, unconjugated  at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C. 100 μL 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated WB C20ORF18 antibody used at 1.25 ug/ml to detect target protein. 100 μg 9 to 11 Days
$369.29
Details
Human Rabbit Un-conjugated IP, WB RBCK1 MaxPab rabbit polyclonal antibody. Western Blot analysis of RBCK1 expression in human stomach. Immunoprecipitation of RBCK1 transfected lysate using anti-RBCK1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with RBCK1 purified MaxPab mouse polyclonal antibody (B01P) . 100 μL 11 to 12 Days
$425.71
Details
Human Mouse Un-conjugated WB Western Blot analysis of RBCK1 expression in transfected 293T cell line by RBCK1 MaxPab polyclonal antibody.Lane 1: C20orf18 transfected lysate(25.3 KDa).Lane 2: Non-transfected lysate. 50 μL 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
$446.88
Details

Top referenced anti-RBCK1 Antibodies

  1. Human Polyclonal RBCK1 Primary Antibody for IHC, IHC (p) - ABIN4349528 : Fiil, Damgaard, Wagner, Keusekotten, Fritsch, Bekker-Jensen, Mailand, Choudhary, Komander, Gyrd-Hansen: OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. in Molecular cell 2013 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal RBCK1 Primary Antibody for IHC (p), ELISA - ABIN542785 : Martinez-Noel, Niedenthal, Tamura, Harbers: A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. in FEBS letters 1999 (PubMed)
    Show all 2 Pubmed References

More Antibodies against RBCK1 Interaction Partners

Human RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) interaction partners

  1. This study demonstrated that Mutations outside the N-terminal part of RBCK1 may cause polyglucosan body myopathy with immunological dysfunction.

  2. The binding of SHARPIN or HOIL-1L facilitates the E2 loading of HOIP.

  3. LUBAC components control TLR3-mediated innate immunity, thereby preventing development of immunodeficiency and autoinflammation.

  4. results unveil HOIL1 as a negative regulator of lymphocyte activation cleaved by MALT1.

  5. HOXA1-mediated activation of NF-kappaB is non-transcriptional and the RBCK1 and TRAF2 influences on NF-kappaB are epistatic to HOXA1

  6. Late in the NF-kappaB activation cycle HOIL1 cleavage transiently reduces linear ubiquitination, including of NEMO and RIP1, dampening NF-kappaB activation and preventing reactivation.

  7. human HOIP is essential for the assembly and function of LUBAC, which includes HOIL-1, and for various processes governing inflammation and immunity in both hematopoietic and nonhematopoietic cells

  8. findings support a role for RBCK1 in the regulation of FKBPL with important implications for estrogen receptor signaling, cell proliferation and response to endocrine therapy.

  9. RBCK1 deficiency is a frequent cause of polyglucosan storage myopathy associated with progressive muscle weakness and cardiomyopathy.

  10. Suggest that RBCK1 is important for the ubiquitination of PXR and may play a role in its proteasomal degradation.

  11. Estrogen receptor-alpha, RBCK1, and protein kinase C beta 1 cooperate to regulate estrogen receptor-alpha gene expression.

  12. Patients from two kindreds of a new fatal inherited disorder characterized by chronic autoinflammation, invasive bacterial infections and muscular amylopectinosis carried biallelic loss-of-expression and loss-of-function mutations in HOIL1.

  13. The solution structure of the HOIL1 Ubl domain was solved using NMR spectroscopy to compare it with that of parkin to determine the structural elements responsible for S5a subunit of the 26S proteasome intermolecular interactions.

  14. analysis of recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex

  15. Data report the identification of the related proteins Sipl1 (Shank-interacting protein-like 1) and Rbck1 (RBCC protein interacting with PKC1) as novel interaction partners of Eya1.

  16. Findings suggest that RBCK1 regulates cell cycle progression and proliferation of ERalpha-positive breast cancer cells by supporting transcription of ERalpha and cyclin B1.

  17. RBCK1 (human C20orf18 and rat Pkcbpb15) is involved in transcriptional machinery in the nuclear bodies, and its transcriptional activity is regulated by nucleocytoplasmic shuttling.

  18. RBCK2 serves as a cytoplasmic tethering protein for RBCK1

  19. HOIL-1 expression stabilizes SOCS6 and induces the ubiquitination and degradation of proteins associated with SOCS6

  20. findings suggest that RBCK1 is involved in negative regulation of inflammatory signaling triggered by TNF and IL-1 through targeting TAB2/3 for degradation

Mouse (Murine) RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) interaction partners

  1. Data show that keratinocyte-specific deletion of ubiquitin-protein ligases HOIP, HOIL-1 (E-KO) and shank-interacting protein-like 1 protein (SHARPIN) results in severe dermatitis causing postnatal lethality.

  2. results demonstrate that both HOIP and HOIL-1 are essential LUBAC components and are required for embryogenesis by preventing aberrant cell death; furthermore, they reveal that when LUBAC and caspase-8 are absent, RIPK3 prevents RIPK1 from inducing embryonic lethality by causing defects in fetal haematopoiesis

  3. HIF regulation of HOIL-1L targets the phosphorylated PKC-zeta for degradation and serves as an hypoxia-adaptive mechanism to stabilize the Na,K-ATPase, avoiding significant lung injury.

  4. Study found that the NZF domain of SHARPIN, but not that of HOIL-1L, is critical for effective protection from programmed cell death by enhancing the recruitment of the linear ubiquitin chain assembly complex to the activated TNFR complex. HOIL-1l seems to be missing the K63-linked ubiquitin chains binding activity which appears to be involved in the recruitment.

  5. Late in the NF-kappaB activation cycle HOIL1 cleavage transiently reduces linear ubiquitination, including of NEMO and RIP1, dampening NF-kappaB activation and preventing reactivation.

  6. These data provide first evidence of a mechanism of cancer cell adaptation to hypoxia where HIFs regulate HOIL-1L, which targets PKCzeta for degradation to promote tumor survival.

  7. analysis of recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex

  8. results demonstrate a powerful approach for the identification of signaling molecules associated with cell surface receptors and indicate an important role for the ubiquitin ligase activity of HOIP in proximal CD40 signaling

RBCK1 Antigen Profile

Protein Summary

The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms.

Gene names and symbols associated with RBCK1

  • SHANK-associated RH domain interactor (SHARPIN) antibody
  • RANBP2-type and C3HC4-type zinc finger containing 1 (RBCK1) antibody
  • ranBP-type and C3HC4-type zinc finger-containing protein 1 (LOC100411512) antibody
  • RanBP-type and C3HC4-type zinc finger containing 1 (Rbck1) antibody
  • RANBP2-type and C3HC4-type zinc finger containing 1 (Rbck1) antibody
  • RanBP-type and C3HC4-type zinc finger containing 1 (rbck1) antibody
  • AL033326 antibody
  • C20ORF18 antibody
  • HOIL-1 antibody
  • HOIL-1L antibody
  • HOIL1 antibody
  • Pkcbpb15 antibody
  • RBCK1 antibody
  • RBCK2 antibody
  • RNF54 antibody
  • Ubce7ip3 antibody
  • UIP28 antibody
  • XAP3 antibody
  • XAP4 antibody
  • zgc:91964 antibody
  • ZRANB4 antibody

Protein level used designations for RBCK1

RanBP-type and C3HC4-type zinc finger containing 1 , ranBP-type and C3HC4-type zinc finger-containing protein 1-like , HBV associated factor 4 , HBV-associated factor 4 , RBCC protein interacting with PKC1 , RING finger protein 54 , heme-oxidized IRP2 ubiquitin ligase 1 , hepatitis B virus X-associated protein 4 , ranBP-type and C3HC4-type zinc finger-containing protein 1 , ubiquitin conjugating enzyme 7 interacting protein 3 , ubiquitin-conjugating enzyme 7-interacting protein 3 , heme-oxidized IRP2 ubiquitin ligase 1 homolog , novel zinc finger, C3HC4 type (RING finger) protein , ubcM4-interacting protein 28 , RBCC protein interacting with PKC 1 , protein kinase C-binding protein Beta15 , protein kinase C-binding protein beta-15

GENE ID SPECIES
430429 Gallus gallus
458025 Pan troglodytes
485818 Canis lupus familiaris
100011102 Monodelphis domestica
100347560 Oryctolagus cuniculus
100411512 Callithrix jacchus
100471387 Ailuropoda melanoleuca
10616 Homo sapiens
504400 Bos taurus
24105 Mus musculus
60383 Rattus norvegicus
431715 Danio rerio
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