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The protein encoded by RBCK1 is similar to mouse UIP28/UbcM4 interacting protein. Additionally we are shipping RBCK1 Antibodies (80) and RBCK1 Kits (3) and many more products for this protein.
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Human RBCK1 Protein expressed in HEK-293 Cells - ABIN2730601
Klein, Fung, Renner, Blank, Dufour, Kang, Bolger-Munro, Scurll, Priatel, Schweigler, Melkko, Gold, Viner, Régnier, Turvey, Overall: The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling. in Nature communications 2015
LUBAC components control TLR3 (show TLR3 Proteins)-mediated innate immunity, thereby preventing development of immunodeficiency and autoinflammation.
results unveil HOIL1 as a negative regulator of lymphocyte activation cleaved by MALT1 (show MALT1 Proteins).
HOXA1 (show HOXA1 Proteins)-mediated activation of NF-kappaB (show NFKB1 Proteins) is non-transcriptional and the RBCK1 and TRAF2 (show TRAF2 Proteins) influences on NF-kappaB (show NFKB1 Proteins) are epistatic to HOXA1 (show HOXA1 Proteins)
Late in the NF-kappaB (show NFKB1 Proteins) activation cycle HOIL1 cleavage transiently reduces linear ubiquitination, including of NEMO (show IKBKG Proteins) and RIP1 (show UQCRFS1 Proteins), dampening NF-kappaB (show NFKB1 Proteins) activation and preventing reactivation.
human HOIP (show RNF31 Proteins) is essential for the assembly and function of LUBAC, which includes HOIL-1, and for various processes governing inflammation and immunity in both hematopoietic and nonhematopoietic cells
findings support a role for RBCK1 in the regulation of FKBPL (show FKBPL Proteins) with important implications for estrogen receptor (show ESR1 Proteins) signaling, cell proliferation and response to endocrine therapy.
RBCK1 deficiency is a frequent cause of polyglucosan storage myopathy associated with progressive muscle weakness and cardiomyopathy.
Suggest that RBCK1 is important for the ubiquitination of PXR (show NR1I2 Proteins) and may play a role in its proteasomal degradation.
Estrogen receptor-alpha (show ESR1 Proteins), RBCK1, and protein kinase C beta 1 (show PRKCB Proteins) cooperate to regulate estrogen receptor-alpha (show ESR1 Proteins) gene expression.
Patients from two kindreds of a new fatal inherited disorder characterized by chronic autoinflammation, invasive bacterial infections and muscular amylopectinosis carried biallelic loss-of-expression and loss-of-function mutations in HOIL1.
Study found that the NZF domain of SHARPIN, but not that of HOIL-1L, is critical for effective protection from programmed cell death by enhancing the recruitment of the linear ubiquitin chain assembly complex to the activated TNFR complex. HOIL-1l seems to be missing the K63-linked ubiquitin chains binding activity which appears to be involved in the recruitment.
Late in the NF-kappaB (show NFKB1 Proteins) activation cycle HOIL1 cleavage transiently reduces linear ubiquitination, including of NEMO (show IKBKG Proteins) and RIP1 (show RALBP1 Proteins), dampening NF-kappaB (show NFKB1 Proteins) activation and preventing reactivation.
These data provide first evidence of a mechanism of cancer cell adaptation to hypoxia where HIFs regulate HOIL-1L, which targets PKCzeta (show PRKCZ Proteins) for degradation to promote tumor survival.
analysis of recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex
results demonstrate a powerful approach for the identification of signaling molecules associated with cell surface receptors and indicate an important role for the ubiquitin ligase (show RNF123 Proteins) activity of HOIP (show RNF31 Proteins) in proximal CD40 (show CD40 Proteins) signaling
The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms.
RanBP-type and C3HC4-type zinc finger containing 1
, ranBP-type and C3HC4-type zinc finger-containing protein 1-like
, HBV associated factor 4
, HBV-associated factor 4
, RBCC protein interacting with PKC1
, RING finger protein 54
, heme-oxidized IRP2 ubiquitin ligase 1
, hepatitis B virus X-associated protein 4
, ranBP-type and C3HC4-type zinc finger-containing protein 1
, ubiquitin conjugating enzyme 7 interacting protein 3
, ubiquitin-conjugating enzyme 7-interacting protein 3
, heme-oxidized IRP2 ubiquitin ligase 1 homolog
, novel zinc finger, C3HC4 type (RING finger) protein
, ubcM4-interacting protein 28
, RBCC protein interacting with PKC 1
, protein kinase C-binding protein Beta15
, protein kinase C-binding protein beta-15